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Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the relationship between coffee consumption and gastric cancer, colorectal cancer, liver cancer, and esophageal cancer by conducting two-sample Mendelian randomization studies. Methods The data of coffee consumption and digestive system malignant tumor were collected from the genome -wide association studies. The genetic loci closely related to coffee consumption were selected as instrumental variables. Mendelian randomization analysis was conducted by inverse variance weighted, MR-Egger, weighted median, and penalized weighted median methods to explore the causal relationship between coffee consumption and the risk of gastric cancer, liver cancer, esophageal cancer, and colorectal cancer. Results The IVW results showed that coffee was associated with gastric cancer (OR=122 95%Ch 1.15-130), colorectal cancer (0R=0.73, 95%CI: 0.68-0.80), liver cancer (OR=0.5& 95%CI: 0.50-0.68)，and esophageal cancer (OR=3.15, 95%CI: 2.53-3.92). Conclusion Coffee consumption increases the risk of gastric and esophageal cancer and has a potential protective effect on colorectal cancer and liver cancer in East Asia. [ABSTRACT FROM AUTHOR]

Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To explore the molecular mechanism of iphigenia indica in the treatment of breast cancer based on network pharmacology molecular docking. METHODS: The active components and their targets of iphigenia indica were collected from traditional Chinese medicine systems pharmacology database and analysis platform（ TCMSP）. The database of breast cancer target was established by GeneCards, online mendelian inheritance in man（ OMIM） and comparative toxicogenomics database（ CTD), and the intersection target of iphigenia indica in the treatment of breast cancer was obtained. Cytoscape Version 3. 7. 1 software and STRING database were used to draw the network diagram of “iphigenia indica-active ingredients-targets ” and protein-protein interaction（ PPI）. Kyoto encyclopedia of genes and genomes（ KEGG） pathway enrichment analysis and gene ontology（ GO） functional enrichment analysis were performed by using R language package. Molecular docking was used to explore the interaction between active ingredients and core targets. Cell experiments were carried out to prove the inhibitory effect of the decoction on the proliferation of breast cancer cells. RESULTS: There were 3 active ingredients and 70 targets in iphigenia indica, including 364 targets in breast cancer. There were 14 targets in the intersection of iphigenia indica and breast cancer targets. Stigmasterol and beta-sitosterol were the most important ingredients of traditional Chinese medicine. The key targets were PTGS2,JUN,ESR1 and NOS3. Go analysis and KEGG enrichment analysis showed that 475 GO pathways and 23 KEGG pathways were screened out, mainly related to cancer pathway and estrogen signaling pathway. The results of molecular docking indicated that there was good binding energy between the compound and the target. Cell experiments confirmed that iphigenia indica has significant anti-tumor effect on breast cancer. CONCLUSIONS: Iphigenia indica has the characteristics of multi-component, multi-target and multi-channel in the treatment of breast cancer, which can provide more references for clinical application. [ABSTRACT FROM AUTHOR]