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Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Pharmaceutical Practice & Service is the property of Journal of Pharmaceutical Practice Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The effect of celecoxib on electrophysiological property of Nav1.5 was studied，which was associated with cardiac toxicity. The effects of celecoxib on the electrophysiological properties of Nav 1.5， including peak current， voltage-dependent activation， voltage-dependent inactivation and recovery kinetics， were investigated by whole cell patch clamp technique. The results showed that celecoxib inhibited the peak currents of Nav1.5 in a concentration-dependent manner with a calculated IC50 value of 1.54×10-8mol/L. Moreover， celecoxib promoted the activation and inactivation phase of Nav1.5， making it somewhat difficult to recover from the inactivation to the resting state. The prominent inhibition of celecoxib on Nav1.5 indicated that there might be a close relationship between potential cardiovascular risks and Nav1.5. [ABSTRACT FROM AUTHOR]