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Objective: Discuss the efficacy of pedicle screw fixation and bone fusion in the treatment of thoracolumbar burst fracture with spinal injury. Methods: Retrospective analysis from March 2010 to December 2014, 93 patients with thoracolumbar burst fracture and spinal injury were selected, male 56 cases, female 34 cases. Cause of injury: 27 cases of traffic accident injury, 47 cases of falling injury, 19 cases of heavy load pressure. Fracture segment: 22 cases of L1 fracture, 16 cases of L2 fracture, 6 cases of L3 fracture, 15 cases of T11 fracture, 34 cases of T12 fracture. Results: There were 93 patients in this study. All patients were followed up for 12 months, the average follow-up was 13.8 months(10-16 months). Compared with the value before surgery, the value of vertebral height ratio was increased, the Cobb's angle and canal occupying rate were decreased apparently after 6 months surgery (t=6.167, 7.241, 7.143, P<0.05). the value of vertebral height ratio was increased, the Cobb's angle and canal occupying rate were decreased apparently after 6 months surgery(t=9.345, 11.541, 11.263, P<0.05). Results: There were significantly difference on these indexes between the values after 6 months and 12 months surgery (t=9.632, 8.154, 7.415, P<0.05). The Frankel nerve function aspect, 35 cases of Grade A recovered after surgery. So the postoperative effective recovery rate of Grade A patients was 87.5%. 25 cases of Grade B recovered after surgery. So the postoperative effective recovery rate of Grade B patients was 89.3%. Besides, the The postoperative effective recovery rate of Grade C and D was 100%. There were no statistical significance on the effective recovery rate between Grade A patients and Grade B, C, D patients(x2=0. 051, 2.196, 1.253, P>0.05). After 12 months follow-up, there were no wound infection, pulmonary infection, deep venous thrombosis and other complications happened. Conclusion: Pedicle screw fixation and bone fusion had a good therapeutic effect on the thoracolumbar burst fracture with spinal injury. The nerve function recovered well and the complications was less. It was worthy of clinical application. [ABSTRACT FROM AUTHOR]