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The occurrence, development, metastasis and invasion of prostate cancer were analyzed based on the traditional Chinese medical theory of Chuanshe and Huchang to obtain the prevention and treatment guidance for bone metastasis of prostate cancer. It is believed that there are similarities in processes between the Huchang and the inflammatory microenvironment of tumor, between the theory of Chuanshe and bone metastasis of prostate cancer, the common theory is the basis to guide the treatment of the disease. The Huchang can be divided into whole Huchang and local Huchang, and the coordination of the whole and local protection field can jointly maintain the stability of the protection 五elT, and the stability of the protection field is the premise to avoid the transmission of Chuanshe. The prevention and treatment of bone metastasis of prostate cancer should adhere to the principle of stable Huchang and avoid ChuansheM ・ Combined with the pathogenesis of bone metastasis of prostate cancer, the main methods of warming kidney Yang, nourishing kidney Yin, invigorating spleen and central methods were used to maintain the stability of whole Huchangt and the methods of dispelling cold and stagnation, detoxifying and removing evil were used to curb cancer toxicity and maintain the stability of local Huchang. And using the method of warming kidney and dispersing stagnation as the main method for preventing and treating prostate cancer bone metastasis. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To research the analgesic effect of galanin on native rats, inflammatory rats and neuropathic rats in nucleus accumbens (NAc), and to explore its mechanism. Methods　A inflammatory pain model was prepared by subcutaneous injection of carrageine into rat’s plantar, while the model of neuralgia was prepared by ligation of the left sciatic nerve. The hind-paw withdraw latency (HWL)induced by thermal stimulation and the hind-paw withdraw threshold (HWT)induced by mechanical stimulation were measured to reflect the pain threshold. The expression of galanin receptors (GalRs) in the nucleus accumbens of inflammatory and neuropathic rats were detected by western blot ( WB). Results 1. The HWL of normal ( Pleft < 0.05; Pright < 0.01), inflammatory (Pleft < 0.001; Pright < 0.001)and neuropathic (Pleft < 0.001; Pright < 0.001) rats were increased by injection of galanin into nucleus accumbens, and the HWT of normal (Pleft < 0.001; Pright < 0.01), inflammatory (Pleft < 0.001; Pright < 0.001)and neuropathic (Pleft < 0.001; Pright < 0.001) rats also were increased. 2. The antinociception of galanin on the rats with inflammatory (HWL: Pleft < 0.05, Pright < 0.05; HWT: Pleft < 0.01, Pright < 0.05)or neuropathic pain (HWL: Pleft < 0.05, Pright < 0.05; HWT: Pleft < 0.001, Pright < 0.001)was stronger than that of the native rats. However, the antinociception of galanin on the rats with the inflammatory pain and neuropathic pain was not significantly different (P > 0.05). 3. The expressions of GalR1 were increased in rats after 3 hours of subcutaneous injection of carrageine (P < 0.001) and 14 days of sciatic nerve ligation (P < 0.001), and the expressions of GalR2 also were increased in rats after 3 hours of subcutaneous injection of carrageine (P < 0.05) and 14 days of sciatic nerve ligation ( P < 0.05). Conclusion Intra-NAc injection of galanin has the antinociceptive effects on native, inflammatory and neuralgia rats and the antinociceptive effect of galanin in rats is induced by the activation of GalRs. [ABSTRACT FROM AUTHOR]

Copyright of Mechanical & Electronic Control Engineering is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)