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Chemotherapy-induced nausea and vomiting ( CINV) are the most common and distressing adverse drug reactions experienced by cancer patients undergoing chemotherapy. In order to provide more standardized, scientific, and rational treatment for CINV, by referring to domestic and foreign clinical guidelines and literature reports, members of the expert group of Traditional Chinese Medicine Group, Oncology Branch of Chongqing Medical Association take the syndrome differentiation and treatment of traditional Chinese medicine as the basic point, combined with the principles of evidence-based medicine, and form the Expert Consensus on Diagnosis and Treatment of Chemotherapy-Induced Nausea and Vomiting in Traditional Chinese Medicine and Western Medicine after repeated discussion and modification. This consensus elaborated on the diagnostic criteria and standardized treatment modes of traditional Chinese and Western medicine for chemotherapy-induced nausea and vomiting [ABSTRACT FROM AUTHOR]

Ｏｂｊｅｃｔｉｖｅ　Ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｃｏｒｒｅｌａｔｉｏｎ ｏｆ ｓｅｒｕｍ ２５ － ｈｙｄｒｏｘｙ ｖｉｔａｍｉｎ Ｄ［２５（ＯＨ）Ｄ］ｌｅｖｅｌ ｗｉｔｈ ｔｈｅ ｓｅｖｅｒｉｔｙ ｏｆ ｉｎｆａｎｔｉｌｅ ｃｈｏｌｅｓｔａｔｉｃ ｈｅｐａｔｏｐａｔｈｙ （ＩＣＨ）． Ｍｅｔｈｏｄｓ　Ａ ｔｏｔａｌ ｏｆ １２１ ｉｎｆａｎｔｓ ｗｉｔｈ ＩＣＨ ｗｈｏ ｗｅｒｅ ａｄｍｉｔｔｅｄ ｏｒ ｒｅｆｅｒｒｅｄ ｔｏ Ｌｉｖｅｒ Ｒｅｓｅａｒｃｈ Ｃｅｎｔｅｒ ｉｎ ｏｕｒ ｈｏｓｐｉｔａｌ ｆｒｏｍ Ｊｕｌｙ ２０１５ ｔｏ Ｄｅｃｅｍｂｅｒ ２０１７ ｗｅｒｅ ｅｎｒｏｌｌｅｄ，ａｎｄ ａｃｃｏｒｄｉｎｇ ｔｏ ｔｈｅ ｐｒｅｓｅｎｃｅ ｏｒ ａｂｓｅｎｃｅ ｏｆ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ，ｔｈｅｓｅ ｉｎｆａｎｔｓ ｗｅｒｅ ｄｉｖｉｄｅｄ ｉｎｔｏ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｇｒｏｕｐ ｗｉｔｈ ２６ ｉｎｆａｎｔｓ ａｎｄ ｎｏｎ － ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｇｒｏｕｐ ｗｉｔｈ ９５ ｉｎｆａｎｔｓ． Ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ ｗｅｒｅ ｃｏｍｐａｒｅｄ ｉｎ ｔｅｒｍｓ ｏｆ ａｇｅ，ｓｅｘ ｒａｔｉｏ， ２５（ＯＨ）Ｄ，ｌｉｖｅｒ ｆｕｎｃｔｉｏｎ ｐａｒａｍｅｔｅｒｓ ［ｔｏｔａｌ ｂｉｌｉｒｕｂｉｎ （ＴＢｉｌ），ｄｉｒｅｃｔ ｂｉｌｉｒｕｂｉｎ （ＤＢｉｌ），ｔｏｔａｌ ｐｒｏｔｅｉｎ （ＴＰ），ａｌｂｕｍｉｎ （Ａｌｂ），ａｌａｎｉｎｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ （ＡＬＴ），ａｓｐａｒｔａｔｅ ａｍｉｎｏｔｒａｎｓｆｅｒａｓｅ （ＡＳＴ），ｇａｍｍａ － ｇｌｕｔａｍｙｌ ｔｒａｎｓｐｅｐｔｉｄａｓｅ （ＧＧＴ），ａｌｋａｌｉｎｅ ｐｈｏｓｐｈａｔａｓｅ （ＡＬＰ），ｔｏｔａｌ ｂｉｌｅ ａｃｉｄ （ＴＢＡ），ａｎｄ ｐｒｏｔｈｒｏｍｂｉｎ ｔｉｍｅ （ＰＴ）］，ｓｅｒｏｌｏｇｉｃａｌ ｍａｒｋｅｒｓ ｏｆ ｌｉｖｅｒ ｆｉｂｒｏｓｉｓ ［ｐｒｏｃｏｌｌａｇｅｎ Ⅲ ｐｅｐｔｉｄｅ （ＰⅢＮＰ），ｌａｍｉｎｉｎ （ＬＮ），ｈｙａｌｕｒｏｎｉｃ ａｃｉｄ （ＨＡ），ａｎｄ ｔｙｐｅ Ⅳ ｃｏｌｌａｇｅｎ （Ｃ － Ⅳ）］，ａｎｄ ｉｎｄｉｃｅｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｖｉｔａｍｉｎ Ｄ ｍｅｔａｂｏｌｉｓｍ （Ｃａ ａｎｄ Ｐ）． Ｔｈｅ ｉｎｄｅｐｅｎｄｅｎｔ ｓａｍｐｌｅｓ ｔ － ｔｅｓｔ ｏｒ ｔｈｅ Ｍａｎｎ － Ｗｈｉｔｎｅｙ Ｕ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｃｏｎｔｉｎｕｏｕｓ ｄａｔａ ｂｅｔｗｅｅｎ ｔｗｏ ｇｒｏｕｐｓ，ａｎｄ ｔｈｅ ｃｈｉ － ｓｑｕａｒｅ ｔｅｓｔ ｗａｓ ｕｓｅｄ ｆｏｒ ｃｏｍｐａｒｉｓｏｎ ｏｆ ｃａｔｅｇｏｒｉｃａｌ ｄａｔａ ｂｅｔｗｅｅｎ ｔｗｏ ｇｒｏｕｐｓ． Ａ ｂｉｎａｒｙ ｌｏｇｉｓｔｉｃ ｒｅｇｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｗａｓ ｕｓｅｄ ｔｏ ｉｎｖｅｓｔｉｇａｔｅ ｔｈｅ ｆａｃｔｏｒｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ． Ｒｅｓｕｌｔｓ　Ｏｆ ａｌｌ １２１ ｉｎｆａｎｔｓ，１０７ （８８． ４３％ ）ｈａｄ ｖｉｔａｍｉｎ Ｄ ｄｅｆｉｃｉｅｎｃｙ，ａｎｄ ａｌｌ ２６ ｉｎｆａｎｔｓ ｗｉｔｈ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｈａｄ ｖｉｔａｍｉｎ Ｄ ｄｅｆｉｃｉｅｎｃｙ． Ｃｏｍｐａｒｅｄ ｗｉｔｈ ｔｈｅ ｎｏｎ － ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｇｒｏｕｐ，ｔｈｅ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｇｒｏｕｐ ｈａｄ ｓｉｇｎｉｆｉｃａｎｔ ｒｅｄｕｃｔｉｏｎｓ ｉｎ ｔｈｅ ｓｅｒｕｍ ｌｅｖｅｌｓ ｏｆ ２５（ＯＨ）Ｄ ａｎｄ Ａｌｂ （Ｚ ＝３.0２９，ｔ ＝２． ２９４，Ｐ ＜０.0５）ａｎｄ ｓｉｇｎｉｆｉｃａｎｔ ｉｎｃｒｅａｓｅｓ ｉｎ ｔｈｅ ｌｅｖｅｌｓ ｏｆ ＤＢｉｌ，ＡＳＴ，ＧＧＴ，ＨＡ，ａｎｄ Ｃ － Ⅳ（Ｚ ＝３.0３２，２.0２６，３． ４３９，３． １４３，ａｎｄ ２． ２４７，Ｐ ＜０.0５），ｗｈｉｌｅ ｔｈｅｒｅ ｗｅｒｅ ｎｏ ｓｉｇｎｉｆｉｃａｎｔ ｄｉｆｆｅｒｅｎｃｅｓ ｉｎ ｔｈｅ ｏｔｈｅｒ ｉｎｄｉｃｅｓ ｂｅｔｗｅｅｎ ｔｈｅ ｔｗｏ ｇｒｏｕｐｓ （ａｌｌ Ｐ ＞０.0５）． Ｔｈｅ ｍｕｌｔｉｖａｒｉａｔｅ ｌｏｇｉｓｔｉｃ ｒｅｇｒｅｓｓｉｏｎ ａｎａｌｙｓｉｓ ｓｈｏｗｅｄ ｔｈａｔ ２５（ＯＨ）Ｄ （ｏｄｄｓ ｒａｔｉｏ ［ＯＲ］＝０． ８６５，９５％ ｃｏｎｆｉｄｅｎｃｅ ｉｎｔｅｒｖａｌ ［ＣＩ］：０． ７５５ －0. ９２２，Ｐ ＝ ０.0３８），ＧＧＴ（ＯＲ ＝ １.0０２，９５％ ＣＩ：１.0００ － １.0０４，Ｐ ＝ ０.0３９），ａｎｄ ＨＡ （ＯＲ ＝ １.0０４， ９５％ ＣＩ：１.0００ －１.0０８，Ｐ ＝０.0３４）ｗｅｒｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｉｎ ｉｎｆａｎｔｓ ｗｉｔｈ ＩＣＨ． Ｃｏｎｃｌｕｓｉｏｎ　Ｓｅｒｕｍ ２５（ＯＨ）Ｄ ｈａｓ ａ ｃｅｒｔａｉｎ ｃｌｉｎｉｃａｌ ｖａｌｕｅ ｉｎ ｐｒｅｄｉｃｔｉｎｇ ｔｈｅ ｓｅｖｅｒｉｔｙ ｏｆ ｈｅｐａｔｏｃｙｔｅ ｄａｍａｇｅ ａｎｄ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｅａｒｌｙ ｌｉｖｅｒ ｃｉｒｒｈｏｓｉｓ ｉｎ ｉｎｆａｎｔｓ ｗｉｔｈ ＩＣＨ． [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)