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Objective: To research the effects of different doses of penehyclidine combined with hemoperfusion in acute organophosphorus pesticide poisoning. Methods: 66 cases patients of acute organophosphorus pesticide poisoning were selected, they were randomly divided into groups A and B, 33 cases in each group. Patients in group A were treated with large dose of penehyclidine combined hemoperfusion, patients in group B were treated with small dose of penehyclidine and hemoperfusion. The clinical treatment effect and the occurrence of adverse reactions during hospitalization were compared between the two groups, the changes of laboratory indexes before and after treatment were compared between the two groups. Results: The recovery time of consciousness, the disappearance time of poisoning symptoms, the recovery time of cholinesterase (CHE) and the hospitalization time in group A was (1.64± 0.42)d, (4.84± 1.25)d, (4.75± 1.21)d, (5.43± 1.88)d respectively, significantly less than (2.10± 0.82)d, (5.22± 1.84)d, (5.67± 1.92)d, (7.24± 2.45)d in group B (P＜0.05), the mortality rate of group A was 0.00% (0/33) significantly lower than that of group B 18.18%(6/33)(P＜ 0.05). The level of partial pressure of carbon dioxide(PaCO2), creatine kinase(CK) and Creatine Kinase Isoenzyme(CK-MB) in group A after treatment was (38.71± 1.44)mmHg, (74.54± 6.12)U/L, (24.45± 3.57)U/L respectively, significantly lower than (42.43± 2.45) mmHg, (82.78± 8.57)U/L, (30.12± 5.75)U/L in group B after treatment(P＜0.05), the arterial partial pressure of oxygen(PaO2) level in group A after treatment was (86.91± 5.76)mmHg, significantly higher than (83.76± 4.87)mmHg in group B after treatment (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups(18.18% VS 11.11%)(P>0.05). Conclusion: Compare with small dose, the treatment of acute organophosphorus pesticide poisoning with large dose of penehyclidine combined with hemoperfusion is more effective and safe. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of plasma exchange combine with hemoperfusion on acute severe organophosphorus pesticide poisoning and its influence on liver function. Methods: 66 patients with acute severe organophosphorus pesticide poisoning who were treated in our hospital from January 2014 to September 2017 were seleced, according to the principle of randomization, the patients were divided into hemoperfusion group (n=30) and combined treatment group (n=36), the two groups received conventional treatment of acute severe organophosphorus pesticide poisoning, on this basis, hemoperfusion group and combined treatment group were treated with hemoperfusion, plasma exchange combined with hemoperfusion. The treatment effects between the two groups.plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin levels before and after 1 weeks of treatment were observed, the adverse reactions during the treatment were observed. Results: Compared with hemoperfusion group, the cholinesterase (CHE) recovery time in the combined treatment group were shorter, the amount of penehyclidine hydrochloride was less, the hospitalization time was shorter, while the success rate of rescue was higher (p<0.05)- The plasma levels of ALT. AST and total bilirubin in the combined treatment group were significantly lower than those in the hemoperfusion group (p<0.05)- There were 1 case of rash in the combined treatment group, the incidence of adverse reactions was 2.78%. and there were no adverse reactions occurred in the hemoperfusion group, there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Plasma exchange combine hemoperfusion can significantly improve the successful rate of salvage in patients with acute severe organophosphorus pesticide poisoning.can improve the liver function of patients and have good safety.which is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]