Objective: To analyze the curative effects of laparoscopic radical prostatectomy for the prostate cancer and the its effect on the level serum hormones levels. Methods: 86 patients with prostate cancer were selected and divided into the control group and the observation group with 43 cases in each group according to the draw method. The control group was treated by open radical prostatectomy, while the observation group was treated by laparoscopic radical prostatectomy. The operation indicators, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), dihydrotestosterone (DHT), free testosterone (FT), total testosterone (T), prostate specific antigen (T-PSA, F-PSA) levels, CD3+, CD4+, CD8+, CD4+/CD8+ before and after the surgery as well as the occurrence of postoperative complications were compared between two groups. Results: The operation time of observation group was significantly longer than that of the control group, and the blood loss, bowel function recovery time, hospital stay, pain scores of observation group was significantly lower or shorter than those of the control group (P＜0.05). No significant difference was found in the serum FSH, LH, DHT, FT, T, T-PSA, F-PSA levels before and after the surgery between two group(P＞0.05). The CD3+, CD4+, CD4+/CD8+ of observation group was significantly higher than those of the control group (P＜0.05), the CD8+ of observation group was lower than that of the control group(P＜ 0.05). The incidence rate of postoperative complication in the observation group was significantly lower than that of the control group (P＜0.05). Conclusion: Laparoscopic radical prostatectomy could play a similar effect with the open surgery on the tumor control, it could improve the level of serum testosterone, immune function with high safety. [ABSTRACT FROM AUTHOR]