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目的 探讨急性缺血性卒中（acute ischemic stroke，AIS）不良出院结局的影响因素，以及感染对出院结局的影响。 方法 回顾性连续纳入2019年6月—2022年6月在首都医科大学附属北京天坛医院神经内科住院治疗的AIS患者，根据出院结局分为结局良好组（mRS评分＜3分）和结局不良组（mRS评分≥3分或住院期间死亡），比较两组患者的临床特点和卒中后感染（肺部感染、尿路感染及中枢神经系统感染）等指标的差异。进一步采用多因素logistic回归分析AIS患者不良出院结局的影响因素。 结果 共纳入AIS患者1024例，平均年龄（60.3±12.4）岁，其中男性788例（77.0%），出院结局良好组761例（74.3%），结局不良组263例（25.7%）。85例患者出现卒中后感染，总体感染发生率为8.3%，其中69例（6.7%）为肺部感染，16例（1.6%）为尿路感染，3例（0.3%）为中枢神经系统感染。多因素分析结果显示，卒中后出现肺部感染（OR 2.522，95%CI 1.318～4.828，P=0.005）、合并糖尿病（OR 1.486，95%CI 1.048～2.106，P=0.026）、入院NIHSS评分升高（OR 1.286，95%CI 1.233～1.342，P＜0.001）和血白细胞计数升高（OR 1.094，95%CI 1.014～1.180，P=0.020）为AIS患者不良出院结局的危险因素。 结论 肺部感染可显著增加AIS患者出院结局不良的风险。 Abstract: Objective To explore the risk factors of adverse discharge outcomes in patients with acute ischemic stroke (AIS), and the effects of post-stroke infection on discharge outcomes. Methods AIS patients who were hospitalized in the Department of Neurology, Beijing Tiantan Hospital, Capital Medical University from June 2019 to June 2022 were retrospectively included in this study. The patients were divided into good outcome group (mRS score

目的 探讨急性卒中患者住院期间感染的临床特征及危险因素，为制订感染预防策略提供思路。 方法 连续纳入2019年6月-2021年6月首都医科大学附属北京天坛医院神经内科收治的缺血性卒中（ischemic stroke，IS）、脑出血（intracerebral hemorrhage，ICH）及蛛网膜下腔出血（subarachnoid hemorrhage，SAH）患者，对其临床资料进行回顾性分析。根据患者住院期间是否发生感染分为感染组和非感染组，比较2组的临床特征、感染部位及时间分布，采用单因素及多因素logistic回归分析感染的危险因素。 结果 共纳入2884例急性卒中患者，男性2138例（74.1%），IS 2049例，ICH 531例，SAH 304例。426例患者住院期间出现感染，发生率为14.8%，感染发生的中位时间为卒中后4（1～7）d。IS、ICH及SAH患者的感染率分别为10.8%、21.3%和29.9%，呈逐渐升高趋势。肺脏为急性卒中后感染率最高且最早出现的感染部位。多因素分析显示，年龄增长（OR 1.038，95%CI 1.026～1.050，P＜0.001）、合并心力衰竭（OR 2.339，95%CI 1.197～4.572，P=0.013）、慢性阻塞性肺疾病（OR 3.297，95%CI 1.676～6.486，P=0.001）、卒中类型为脑出血（OR 2.162，95%CI 1.548～3.021，P＜0.001）或蛛网膜下腔出血（OR 8.271，95%CI 5.591～12.236，P＜0.001）、入院NIHSS升高（OR 1.162，95%CI 1.132～1.193，P＜0.001）及住院时间延长（OR 1.138，95%CI 1.109～1.168，P＜0.001）为急性卒中患者住院期间发生感染的独立危险因素。 结论 感染是急性卒中患者常见的并发症之一，其中肺部感染发生率高且发病时间早。年龄升高、合并心力衰竭或慢性阻塞性肺疾病、神经功能损伤较重的患者感染发生率升高，与IS相比，ICH和SAH患者的感染发生率升高。 Abstract: Objective To investigate the clinical characteristics and risk factors of infection in patients with acute stroke during hospitalization, and to provide clinical guidance for the infection prevention strategies. Methods The patients with either ischemic stroke (IS), intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH) who were admitted to Beijing Tiantan Hospital from June 2019 to June 2021 were included in this retrospective study. According to having post-stroke infection or not during hospitalization, patients were divided into infection group and non-infection group. The clinical characteristics, infection sites and time distribution were compared between two groups. Univariate and multivariate logistic regression analysis were used to determine the risk factors for post-stroke infection. Results A total of 2884 patients with acute stroke were enrolled, including 2138 (74.1%) males, 2049 patients with IS, 531 patients with ICH, and 304 patients with SAH. 426 (14.8%) patients developed infection during hospitalization, with a median infection time of 4 (1-7) days after stroke. The infection rates were 10.8%, 21.3% and 29.9% in patients with IS, ICH and SAH, respectively, showing a significant increasing trend. Lung was the highest and earliest infection site in patients with acute stroke. Multivariate analysis showed that increasing age (OR 1.038, 95%CI 1.026-1.050, P

Copyright of Laser Technology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To explore the adverse events (ADE) signals of crizotinib, so as to provide reference for medication safety in the clinic. METHODS: Reports of crizotinib-related ADE were collected from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database from Aug. 26th, 2011 to Mar. 31st, 2023. Reporting odds ratio (ROR) method and medicines and healthcare products regulatory agency method (MHRA) were used for data mining. The preferred system organ classification ( SOC) and preferred terminology (PT) in the ICH Medical Dictionary for Regulatory Activities (MedDRA) were used to describe, classify and analyze ADE. RESULTS: A total of 22 493 ADE reports related to crizotinib were retrieved. Most of the patients were male (11 862 cases, 52. 74%) and were ≥65 years old (109 cases, 0. 48%). The main reporting country was the United States (12 837 cases, 57. 07%). A total of 18 370 severe ADE were involved, mainly for hospitalization (4 595 cases, accounting for 25. 01% of the total number of severe ADE). A total of 61 453 ADE signals were detected, including 15 kinds of SOC, which were mainly systemic diseases, various reactions at the drug administration site, and gastrointestinal functional diseases. ADE signals with the highest ranked number of reported cases were related to PT such as death, diarrhea, nausea and fatigue. ADE signals with the highest ranked signal intensity were related to PT such as soft tissue sarcoma, malignant connective tissue tumor, and metastatic synovial sarcoma. CONCLUSIONS: ADE induced by crizotinib mainly includes systemic abnormalities, gastrointestinal reactions, abnormalities of various examination indicators. Before the application of crizotinib, clinical evaluation should be done, and the blood indicators and systemic response of patients should be focused on during treatment to ensure the safety of treatment. [ABSTRACT FROM AUTHOR]

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Copyright of Machine Tool & Hydraulics is the property of Guangzhou Mechanical Engineering Research Institute (GMERI) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Arsenic is a carcinogen and a causative agent of cardiovascular and peripheral vascular disease, neurological disorders, diabetes mellitus and various forms of cancer. Objective: Used Bioinformatics methods such as GO database and KEGG database to evaluate the differentially expressed genes in GEO database data. Methods; Functional enrichment, functional annotation analysis and survival analysis of the differential genes were performed by using bioinformatics analysis software. Results; Used protein-protein interaction network (PPI) software on Gvtoscape to analyze 179 differential genes. A total of 126 genes were found to be acting on protein targets, and 10 of them were key genes, respectively; PSMB3, HSP70\, HSPE\, STIPX, HSPD1, HSP70, DNAJBIB,/7SP90A41.1, I1SP A9H, TCP I; Conclusion; The core genes mainly act on protein processing in endoplasmic reticulum pathway. Il provides a new research direction for the potential biomarkers and biological mechanisms of arsenic induced liver injury. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Functional Materials / Gongneng Cailiao is the property of Chongqing Functional Materials Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To analyze the efficacy and safety of low dose glucocorticoid combined with continuous blood purificationin the treatment of severe sepsis in children. A total of 102 children with severe sepsis from January 2021 to January 2023 wereselected as research objects and randomly divided into matched group and observation group, with 51 cases in each group. The matchedgroup was given classical treatment, and the observation group was given low-dose glucocorticoid combined with continuous blood purification on the basis of the matched group. The information of the two groups after treatment was recorded. The peripheral blood lacticacid, central venous oxygen saturation (ScvO2), serum inflammation index, PCIS score, APACHEⅡ score before and after treatment were compared between the two groups, and the occurrence of main complications was observed. Compared with the matched group, mechanical ventilation, hypotension and admission to the ICU were shorter, and the rate of stopping the booster within 7 d washigher (P<0.05). There was no difference in 28 d mortality between the two groups(P>0.05). After treatment, the levels of lactic acid, pro-calcitonin (PCT), tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) in observation group were lower than those in matched group, while the level of ScvO2 was higher than that in matched group (P<0.05). After treatment, PCIS score of observation group was higher than that of matched group, APACHE Ⅱ score was lower than that of matched group (P<0.05). The incidence of main complications in the observation group was lower than matched group (P<0.05). Low-dose glucocorticoid combined with continuous blood purification treatment is conducive to the disease outcome of children with severe sepsis, reduce the occurrence of major complications, and may be related to the blockade of inflammatory response, which deserves further research and application. [ABSTRACT FROM AUTHOR]

Copyright of Electric Power Automation Equipment / Dianli Zidonghua Shebei is the property of Electric Power Automation Equipment Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering Management / Gongcheng Guanli Xuebao is the property of Journal of Engineering Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

【Objective】A mathematical evaluation model, D(x), was established to provide a reference for the evaluation, identification and genetic improvement of seed vitality traits in rice.【Method】Taking 25 rice seeds as materials, multiple indexes were determined through standard germination experiment, tetrazolium staining identification, field simulation experiment and Q2 technology, and these indexes were analyzed by principal component analysis combined with membership function method and multiple linear regression, to establish the mathematical evaluation model for seed vitality, D(x). And the D(x) model was used to evaluate the influence of different cultivation densities on rice seed vitality.【Result】The results showed that the average values of germination vigor, germination rate, 7-day bud length, hundred-seed fresh weight, field bud length, field root length, starting metabolism rate (SMR), increased motabolism time (IMT), relative germination time (RGT), and tetrazolium staining rate of indica rice were all higher than those of japonica rice. However, only the average values of 7-day root length, hundred-seed dry weight, and oxygen metabolism rate (OMR) of indica rice were slightly lower than those of japonica rice. In the Q2 test, japonica rice exhibited better performance in IMT value, RGT value, and other indicators. Correlation analysis of 13 rice seed vitality indexes revealed varying degrees of correlations among them. In the Q2 test, SMR value was extremely significantly correlated with IMT value, OMR value, RGT value, and hundred-seed dry weight, and significantly correlated with field bud length. OMR value was extremely significantly correlated with SMR value, IMT value, RGT value, and significantly correlated with germination vigor. A seed vitality comprehensive mathematical evaluation model Y(x) = 0.693+0.003X1-0.006X2-0.127X6-0.004X8+0.234X9 (R²=0.94) was established through stepwise regression. The predicted vitality values (Y) obtained from these five indexes were in close agreement with the order of field emergence rate among the tested materials, and they were highly correlated (r=0.83), indicating that this regression equation could effectively predict rice seed vitality.【Conclusion】Five individual indexes, namely, germination vigor, germination rate, hundred-seed dry weight, oxygen metabolism rate (OMR) and germination initiation time (IMT) could be selected as the basis for the evaluation of seed vitality. [ABSTRACT FROM AUTHOR]

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Disruptive technologies have key impact on the path, direction, and international competition pattern of future industrial development, so the forward-looking layout of future industries driven by disruptive technologies is an inevitable choice for China to seize the commanding heights of science and technology and accelerate the construction of a new development pattern. Based on the in-depth analysis of the whole process and whole chain of the United States' Electronics Resurgence Initiative layout of disruptive technologies and the technology identification mechanism, organization management mechanism, evaluation mechanism, and demonstration application mechanism of cultivating future industries, this study extracts the scientific connotation and key elements of disruptive technologies and future industries, and constructs the research framework of "disruptive technology-driven future industry cultivation model" from the links of "disruptive technology supply-technology industry transformation-technology industry application". Relevant research findings have key reference significance for China's cultivation of future industries driven by disruptive technologies. This study proposes that China should establish a long-term and dynamic disruptive technology identification and support mechanism for future industries, further strengthen the marketoriented and multi participation management model and policy design, establish a dynamic comparison and competitive exit mechanism of disruptive technologies with multiple technical routes in parallel, tolerate failures caused by objective factors such as technology research and development and technical routes, form an assessment and evaluation mechanism differentiated from the key core technology research, improve the demonstration and application of disruptive technologies for future industrial application scenarios, and promote pilot demonstrations and application scenarios such as future industry pilot demonstration zones. [ABSTRACT FROM AUTHOR]

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As one of the first natural fibers cultivated and used by human beings, the flax fiber is known as the "queen of the plant fibers", due to its excellent performance, such as fast heat dissipation, high strength, anti-pest and mildew, and excellent breathability. Compared with the cotton fiber, the most commonly used fiber in textile industry, the flax fiber contains a higher content of lignin, hemicellulose, pectin and other colloidal and impurity components.These colloidal materials have adverse effects on the dyeing and finishing of the final/intermediate products.Degumming is a necessary step to obtain high quality flax fiber. The traditional chemical degumming method have caused heavy environment pollution and cellulose degradation. Thus, to develop a green and sustainable degumming method for flax fibers, an environmentally friendly method for flax degumming with low degradation of cellulose is established. Firstly, as the laccase mediator system (LMS) has excellent delignification ability, we established the laccase TEMPO system by using TEMPO as a small molecular mediator. Taking residual rate of lignin and fiber weight loss rate as the indicators, we discussed the effects of key factors including treatment temperature, pH value, bath ratio, time, laccase concentration, TEMPO concentration on the experimental results with single factor experiment. Secondly, we selected EDTA with appropriate concentrations to strengthen the effect of the laccase TEMPO system. We applied the EDTA-enhanced laccase/TEMPO system to the flax degumming in this study. We used EDTA to remove pectin from flax at first, so as to improve the accessibility of laccase to lignin, and to improve the lignin removal rate. We put forward a new idea of delignification by removing pectin. Experimental results showed that this system had an excellent degumming effect under the optimal process conditions (laccase of 1.5 U /mL, TEMPO of 0.2 g /L, EDTA of 20 mmol /L, a pH value of 4.0 and a bath ratio 1:20 at the temperate of 55 ℃ for 4 h).Under this condition, the lignin removal rate reached 56.74%, the pectin content decreased by 32.62%, the hemicellulose content decreased by 2.12%, the water-soluble matter content decreased by 54.42%, and the lipowax content decreased by 39.06%. Moreover, the gummy materials on the surface of the fiber were reduced, and the fiber fineness was significantly improved after the EDTA-enhanced laccase/TEMPO system treatment. In addition, the EDTA-enhanced laccase/TEMPO system had little damage to cellulose and maximized the retention of fiber strength. Although this system has a high removal rate of lignin, pectin and other substances in flax, the removal rate of hemicellulose which is one of the main components in degumming can not catch the standard. This may be due to the lack of reagents for hemicellulose degradation in the degumming formula, which needs to be improved in follow-up explorations. [ABSTRACT FROM AUTHOR]

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The Ag@AgCl/Bi4Ti3O12photocatalyst was used to treat the methylene blue solution under visible light. The effects of the photocatalyst dosage, the pH value of the wastewater and the photodeposition time on the degradation effect were investigated. The photocatalytic reaction kinetic analysis was performed. The results show that when the photocatalyst dosage is 180 mg, the pH value is 10,and the photodeposition time is 30 min, the degradation effect of 200 mL of 10 mg/L MB solution for 60 min with a 300 W xenon lamp. The photocatalytic decolorization rate reaches 98.96%,the first-order reaction kinetics of the Ag@AgCl/Bi4Ti3O12 catalytic degradation of MB solution under visible light has a good fit value, the surface reaction rate k reaches 0.074 11 min-1,and the half-life t1/2 is 9.35 min, which further proves that Ag@AgCl/Bi4Ti3O12 has better catalytic performance. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Runoff generation can be greatly varied in the events, such as the climate, catchment properties, and scale under the action of field ridges in farmland. It is crucial to better understand the spatiotemporal patterns of runoff generation for the process-based hydrological modelling. The evolution of the hydrologic cycle in the plain areas can also be strengthened to link the run-off behavior associated with the changes in environmental and land use conditions. However, it is still lacking on the relationship between the rainfall characteristics, ridge height, and the runoff generation in farmland. Taking the Haihe River Basin in northern China as the research area, this study aims to characterize the rainfall events using the Climate Prediction Center (CPC) Morphing Technique (MORPH, CMOPRH) remote sensing precipitation data products. Smith-Parlange infiltration method was used to construct a water flow model for the farmland accumulation, and then to simulate the rainfall and runoff generation process in the study areas. The results are as follows. 1) The total amount and duration of rainfall events in the study Plain were mainly less than 25 mm and 10 h in the field, accounting for 95% and 96% of the total rainfall events, respectively. In rainfall intensity, the light, moderate, and heavy rain accounted for 87%, 11%, and 1.9% of the total rainfall, while the rainstorm only accounted for 0.1% of the total rainfall. There was also a significant decrease in the total amount of rainfall and rainfall intensity from the northeast to the northwest. 2) The mean annual runoff was 5.47 billion m³ in the study area from 2008 to 2019, of which the farmland runoff was 2.18 billion m³, accounting for about 40% of the total runoff. Specifically, the yield of the Tuhaimajia River Basin was the highest, with an annual mean of 1.95 billion m³, whereas, that of the Ziya River Basin was the lowest, with an annual mean of 100 million m³. Four scenarios of no ridge, 10, 12, and 15 cm ridge were simulated under the rainfall conditions from 2008 to 2019, where the annual mean runoff generations of farmland were 6.24, 1.97, 1.31, and 0.5 billion m³/year, respectively. 3) Once the height of ridge was the constant, the rainfall duration and intensity were the key factors to affect the runoff generation of farmland. An inverse proportional function curve was fitted to classify the rainfall whether the runoff generation or not, where the rainfall duration and intensity were taken as the horizontal and vertical coordinate, respectively. For example, the runoff was formed at the ridge height of 10 cm, where the rainfall intensity was 10 mm/h, and the rainfall duration was more than 15.9 h. Once the rainfall intensity was 30 mm/h, and the rainfall duration was 2.4 h, the farmland runoff was formed in the study area. 4) The amount of farmland runoff decreased by 1.02 billion m³ in the study area in 2000, compared with 1979. This variation was attributed to both the evolution of the farmland area and the transition from no ridges to ridges in simulation. The amount of farmland runoff decreased by 510 million m³ in 2016, compared with 2000, which was mainly influenced by the decrease in the farmland area. Correspondingly, there was a significant decrease in the farmland runoff, due mainly to the decrease in the farmland area during the acceleration of urbanization in the study areas since 2000. Anyway, the quantitative analysis was offered to clarify the effects of rainfall characteristics and ridge height on farmland runoff generation. The finding can provide a strong reference to explore the causes of surface water resource attenuation in the Haihe plain area of northern. [ABSTRACT FROM AUTHOR]

Copyright of Acta Materiae Compositae Sinica is the property of Acta Materiea Compositae Sinica Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)