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近邻宜居行星巡天计划(Closeby Habitable Exoplanet Survey, CHES)采用空间微角秒级别的高精度天体测量技术, 普查太阳系近邻(10 pc内)约100颗FGK等类型恒星, 探测宜居带类地行星或超级地球; 详细普查宜居行星的数目、真实质量和三维轨道等信息, 这将是国际上首次近邻宜居带类地行星的空间探测任务. CHES的有效载荷是一台口径为1.2 m, 视场为0.44°×0.44°, 焦距为36 m的高像质、低畸变、高稳定光学望远镜, 采用同轴三反TMA光学成像系统. 为实现宜居带类地行星探测, CHES任务中的测量精度为1 μas, 是目前国际测量精度最高的空间探测项目. 在空间科学先导专项背景型号项目的支持下, CHES团队深入凝练和论证科学目标, 成功突破了三项关键技术难题: 实现了畸变大视场高像质空间望远镜光学系统技术的重要突破; 突破了10–5 pixel级别星间距测量技术; 实现了卫星系统高稳定度姿态控制精度及热控精度的创新. CHES预计发现50颗类地行星, 引领中国空间科学探测技术的跨越式发展.

OBJECTIVE: The effect of post-activation potentiation on sports performance is characterized by increased muscle mobility and increased rate of muscle force generation. In this paper, Meta-analysis is used to quantitatively evaluate the effects of post-activation potentiation on sprint speed, jumping performance, and kinetic parameters (peak impulse, peak power, maximum ground reaction force, rate of force generation, etc.) after activation of relative strength levels in the lower limbs. METHODS: Electronic databases such as CNKI, WanFang, Web of Science, PubMed, and Medline were retrieved for randomized control, random crossover, or clear grouping according to the relative strength levels of the lower limbs (non-randomized controls) on the post-activation potentiation effect after activation induced by the relative strength level of the lower limbs. Free weight equipment and rapid telescopic compound exercises were used as main intervention methods in each group. The publication time of the literature was from the inception of each database until August 5, 2023. Endnote software was used to manage the literature. Literature quality assessment was conducted using the PEDro scale for randomized controlled trials and ROBINS-I 2.0 standards for nonrandomized controlled trials. Revman5.4 and Stata15.0 software were used to conduct publication bias evaluation, subgroup analysis and sensitivity analysis of the extracted data, and forest plots were produced for Meta-analysis. RESULTS: Eleven documents (seven randomized controlled trials and four non-randomized controlled trials) were finally included, including 216 subjects. Overall, the methodological quality of the literature was high. According to the grouping standard of 1-repetition maximum/body mass > 2 for the strong group and 1-repetition maximum/body mass ≤ 2 for the normal group, there were 99 subjects in the strong group and 117 subjects in the normal group, all of whom were male. The positive effect of post-activation potentiation on sprint performance in the strong group was significantly higher than that in the normal group [standardized mean difference (SMD)=-1.34, 95% confidence interval (CI): -1.74 to -0.93, P < 0.000 01]; the positive effect of post-activation potentiation on vertical jump height showed no significant difference between the strong and normal group (SMD=0.30, 95% CI: -0.07 to 0.66, P=0.11); the positive effect of post-activation potentiation showed no significant difference between the strong and normal groups in terms of peak impulse (SMD=-0.07, 95% CI:-0.62 to 0.47, P=0.61], peak power (SMD=0.21, 95% CI:-0.29 to 0.72, P=0.12), maximum ground reaction force (SMD=0.31, 95% CI: -0.20 to 0.81, P=0.16) and force generation rate (SMD=0.36, 95% CI: -0.11 to 0.82, P=0.39). CONCLUSION: The post-activation potentiation effect in the strong group can significantly increase the short-distance sprint speed. The potentiation effect after activation of the relative strength level of the lower limbs has similar effects on the kinematic and kinetic parameters, including explosive vertical jump height, peak impulse, peak power, maximum ground reaction force and force generation rate. [ABSTRACT FROM AUTHOR]

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Edge computing brings storage and compute resources down to the edge of the network. Users can offload latencysensitive and compute-intensive applications to the edge server for execution, thereby reducing latency and energy consumption. Existing task offload studies often fall short. The first point is that the existing research on task offloading often overlooks the heterogeneity of offloading tasks. The second point is that the default edge server caching service can meet the long-term service needs of users. However, different tasks require different services to provide execution environments. And the finite resources of edge servers can only deploy a small number of services. Therefore, to minimize latency and energy consumption (i. e. cost), this article proposed a heterogeneous task offloading method that combined service updates and cloud edge collaboration. The method consisted two following main parts. The first part was an improved page replacement algorithm. The algorithm could predict the potential user service demand and updated the service of the edge server in time. The second part was the collaboration between the cloud-side ends, offloading tasks through collaboration and keeping minimum total costs. Finally, it conducted thorough experiments using real datasets. The experimental results show that the proposed method can reduce the total cost by 7% to 16% compared to the comparison methods. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Control Theory & Applications / Kongzhi Lilun Yu Yinyong is the property of Editorial Department of Control Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Drainage & Irrigation Machinery Engineering / Paiguan Jixie Gongcheng Xuebao is the property of Editorial Department of Drainage & Irrigation Machinery Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: The Canadian university where this study took place has established an international exchange program in teacher education with a large Chinese university. This study was designed to examine how the international exchange program influenced Chinese science teacher candidates’ understanding of science education and how such learning impacted their teaching in China. Design/Approach/Methods: The study adopted a qualitative research design with interview and reflective journal as the main approaches for data collection. Findings: Participants greatly appreciated the opportunity of exchange. They reported an improved understanding of Canadian school education and its science curriculum and pedagogy, which changed many aspects of their original values about the relationship between the teacher and students, classroom environment, and so on. Although they faced many constraints to implement what they learned from the exchange in Chinese science classrooms, what they learned had never been forgotten. Participants tried to apply them here and there at the level they could control. Originality/Value: There are many reported studies in the literature about Chinese international students on Western campuses. However, research on Chinese students who participate in international exchange programs is very rare. The findings of this study can inform policymakers and education practitioners about student international exchange programs and benefit future exchange participants.

BACKGROUND: The phosphatidylinositol 3-kinase/protein kinase (PI3K/AKT) signaling pathway plays a pivotal role in regulating osteoclast activation, which is essential for maintaining bone homeostasis. Bone destruction in osteoarticular tuberculosis is caused by aberrant osteoclastogenesis induced by Mycobacterium tuberculosis infection. However, the role of the PI3K signaling pathway in Mycobacterium tuberculosis-induced aberrant osteoclastogenesis remains unclear. OBJECTIVE: To investigate the effects and mechanisms of the PI3K/AKT signaling pathway inhibitor BYL-719 on aberrant osteoclastogenesis induced by Mycobacterium tuberculosis. METHODS: RAW264.7 cells were infected with bovine Mycobacterium tuberculosis bacillus calmette-cuerin vaccine, and Ag85B was used for cellular immunofluorescence staining. The cell counting kit-8 assay was employed to determine the safe concentration of BYL-719. There were four groups in the experiment: blank control group, BYL-719 group, BCG group, and BCG+BYL-719 group. Under the induction of receptor activator of nuclear factor kappa-B ligand, the effects of BYL-719 on post-infection osteoclast differentiation and fusion were explored through tartrate-resistant acid phosphatase staining and phalloidin staining. RT-PCR and western blot were used to detect the expression of osteoclast-related genes and proteins, and further investigate the mechanism of action. RESULTS AND CONCLUSION: Immunofluorescence staining showed that RAW264.7 cells phagocytosed Mycobacterium tuberculosis. Cell counting kit-8 data indicated that 40 nmol/L BYL-719 was non-toxic to cells. Tartrate-resistant acid phosphatase staining and phalloidin staining showed that BYL-719 inhibited the generation and fusion ability of osteoclasts following infection. RT-PCR and western blot results also indicated that BYL-719 suppressed the upregulation of osteoclast-specific genes (including c-Fos, NFATc1, matrix metalloproteinase 9, and CtsK) induced by Mycobacterium tuberculosis infection (P < 0.05). Western blot and immunofluorescence staining revealed that BYL-719 inhibited excessive osteoclast differentiation induced by Mycobacterium tuberculosis by downregulating the expression of IκBα-p65. To conclude, BYL-719 inhibits aberrant osteoclastogenesis induced by Mycobacterium tuberculosis through the downregulation of IκBα/p65. Therefore, the IκBα/p65 signaling pathway is a potential therapeutic target for osteoarticular tuberculosis, and BYL-719 holds potential value for the preventing and amelioration of bone destruction in osteoarticular tuberculosis. BYL-719 has the potential to prevent and ameliorate bone destruction in osteoarticular tuberculosis [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Bulletin of the Chinese Ceramic Society is the property of Bulletin of the Chinese Ceramic Society Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Autoimmune disease (AID) is a disease in which the body loses tolerance to autoantigens and the immune system attacks its own tissues, resulting in organ and tissue damage and certain clinical manifestations. Studies have proved that pathogenic T cells can be selectively inhibited or killed by TCR vaccine in the treatment of AID, thus bringing broad application prospect. This paper briefly summarizes the research status of TCR vaccine in AID field, regarding action mechanism, related diseases and safety of TCR vaccine. [ABSTRACT FROM AUTHOR]

Objective: Analyzing the gene expression microarray of patients experiencing acute asthma by bioinformatics methods, in order to explore the mechanism of acute asthma and to identify early indicator of acute asthma attacks. Methods: The GSE103166 microarray dataset was retrieved from the GEO database, and after cleaning and organizing the data, differential expression analysis was conducted between children experiencing acute asthma attacks and non-asthmatic children. Enrichment analysis was performed using R language to annotate the functions of the differentially expressed genes (DEGs). Using gene interaction information, a network of interactions among these genes was constructed, and the network structure was deconstructed to identify key genes and regulatory sub-networks. Results: GSE103166 data set contained 87 nasal swab specimens from children (56 cases of acute asthma, 31 cases of control). Compared with control group, the acute asthma group had 63 differentially expressed genes (39 upregulated and 24 downregulated). The results of enrichment analysis showed that the DEGs were primarily enriched in endocytic vesicle and endocytic vesicle membrane. Among these, CD163 was the only gene significantly upregulated in both cellular components. The network dismantling analysis demonstrated four different sub-networks. CD163 was involved in sub-network Ⅰ, which was composed of CD163, ARG2, CAT, GSTA2, SCNN1G and MT2A. Among them, ARG2 and CAT were at the regulatory center of the network. Conclusion: CD163 and regulatory networks based on CD163, ARG2, CAT, GSTA2, SCNN1G and MT2A are possible the crucial factors contributing to acute asthma. This study provides research ideas for the precise and early identification of biomarkers and therapeutic targets for acute asthma attacks. [ABSTRACT FROM AUTHOR]

In marine biology research and fishing industries, ships using underwater robots to capture and identify marine organisms may face limited communication bandwidth and computing resources, making lightweight network models better suited for such conditions. To address this issue, a modified YOLOv5n model for marine organism detection was proposed, incorporating improvements in the neck network, model pruning, and knowledge distillation techniques. The model size was effectively reduced by leveraging the Gsconv lightweight convolution module to replace standard convolutions in the YOLOv5n Neck section. A novel α- giou loss function was adopted to enhance bounding box regression accuracy. Based on weight coefficients, L1-norm regularization pruning was applied to eliminate unnecessary channels and associated convolutional kernels. Finally, retraining and L2 knowledge distillation were employed to fine-tune the model accuracy close to pre-pruning levels. Experimental results demonstrated a 53% reduction in computational load and a 51% decrease in parameters compared to the original YOLOv5n baseline network. The proposed algorithm ensures the effectiveness [ABSTRACT FROM AUTHOR]

Transthyretin cardiac amyloidosis (ATTR-CA) has been considered as a rare cardiac dysfunction with occult onset, rapid progression and high mortality, caused by the accumulation of transthyretin fibrils in the myocardium. Recently, with the development of diagnostic techniques, its detection rate has been increasing. The continuous emergence of various small molecule drugs has also changed the previous situation of lacking therapeutic agents, and its mortality has been reduced. This paper mainly summarizes the latest advances in the diagnosis and treatment of ATTR-CA in recent years. [ABSTRACT FROM AUTHOR]

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