The impact of climate change on the agriculture production in semi-arid areas of Northwest, the major drought-resistant technology, the mechanism of increasing grain production were analyzed to explore technical solutions to retort the future climate change, future development of rainfed agriculture, and provide reference for food security. The results showed that the impact of future climate change on crop growth had main three aspects: Firstly, higher temperatures resulted in lower crop yield and quality decline; Secondly, changes in precipitation and precipitation patterns resulted in drought/flooding problems; Thirdly, meteorological disasters caused by extreme weather lead to fluctuations of food production. To adapt or mitigate these adverse effects, increase use efficiency of limited rainfall, optimize soil structure, improve soil fertility, enhance withstanding environmental change ability of crop-soil system, mitigate the impact of future climate change on food production in semi-arid region of Northwest China, the mainly solutions were:(1)Covering gathered precipitation, improve the ability to accumulate soil moisture, change the distribution of soil moisture, regulate the migration and improve the infiltration of precipitation, thus “adjusting water”to adapt to precipitation changes;(2)Optimizing soil structure, physical and chemical properties by soil fertilization, thus “regulating soil”to improve the ability of crop-soil system against to environmental changes, in order to stabilize productivity of rainfed agriculture;(3)Integrate“adjusting water”and“regulating soil”technology, forming technical system of“coordination of water and soil”to comprehensively response to future climate change, mitigate the adverse impact of future climate change on food production in semi-arid region of Northwest, China. [ABSTRACT FROM AUTHOR]