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Copyright of Automobile Technology & Material is the property of Automobile Technology & Material Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Immunology is the property of Medical Periodical Society of Jilin and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the survival and adverse reactions of patients with unresectable cholangiocarcinoma after stereotactic body radiation therapy (SBRT). Methods A total of 27 patients with unresectable solitary cholangiocarcinoma without metastasis who underwent SBRT in The Fifth Medical Center of Chinese PLA General Hospital from February 2012 to July 2020 were enrolled. The prescribed dose to planning target volume was 42-60 Gy in 5-8 fractions, with 5-11 Gy/fraction. Among these patients, five patients were also treated with chemotherapy and transcatheter arterial chemoembolization. The 6-, 12-, 18-, and 24-month overall survival (OS) rates, progression-free survival (PFS) rates, and local control (LC) rates were used as the assessment indices for treatment outcome；Common Terminology Criteria for Adverse Events v. 4.03 was used to evaluate adverse reactions； the Kaplan-Meier method was used to calculate OS, PFS, and LC rates. Results The median follow-up time was 17 months. For all 27 patients, the 6-, 12-, 18-, and 24-month OS rates were 100%, 88%, 57.5%, and 47.9%, respectively； the 6-, 12-, 18-, and 24-month PFS rates were 74.1%, 58.6%, 47.9%, and 35.9%, respectively； the 6-, 12-, 18-, and 24-month LC rates were 96.3%, 91.9%, 84.8%, and 76.4%, respectively. No grade 3 or above toxic reactions were observed. Five patients were diagnosed with radiation-induced liver injury, but there was no death due to radiation-induced liver injury. Conclusion SBRT is safe and effective in the treatment of unresectable cholangiocarcinoma, with relatively high survival rate, PFS rate, and LC rate and low toxicity, and therefore, SBRT can be used as an alternative treatment method for patients with cholangiocarcinoma who are not candidates for surgery. [ABSTRACT FROM AUTHOR]

Copyright of Engineering Management & Technology Discussion is the property of Omniscient Pte. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Two compounds (1 and 2) were isolated and purified from secondary metabolites of Colletotrichum scovillei by silica gel column chromatography, sephadex chromatography, thin layer chromatography and high-performance liquid chromatography. Their chemical structures were elucidated by spectroscopic technologies including nuclear magnetic resonance (NMR) and mass spectroscopy (MS). 1 was identified as a new ceramide 6-methyl-12-hydroxy-tetradeca-N-(2′,3′,4′- trihydroxybutyl)-2E,4Z-dienamide, and 2 was the known compound sambutoxin. Compounds 1 and 2 had good antifungal activity against Exserohilum turcicum, with EC50 values of 11.43 μg/mL and 18.42μg/mL, respectively. The results of in vitro leaf assay showed that at the concentration of 800 μg/mL, compound 1 had significant effects on northern corn leaf blight and the relative control efficacy was 84.8%, which was equivalent to that of chlorothalonil. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the efficacy and safety of sequential lenvatinib therapy after stereotactic body radiotherapy (SBRT) in the treatment of advanced primary liver cancer. Methods A total of 18 patients with advanced primary liver cancer who were admitted to The Fifth Medical Center of Chinese PLA General Hospital from October 2018 to May 2019 were enrolled, among whom there were 4 patients with BCLC stage B liver cancer and 14 patients with BCLC stage C liver cancer. The prescribed dose of planning target volume was 48-55 Gy (median 50 Gy) in 6-9 fractions, and the median of single dose was 6 (5-9) Gy per fraction. Oral administration of lenvatinib was given since 1 week after SBRT was finished, with a median medication time of 9.5 (3.6-25.8) months. Follow-up was performed once a month for the first 3 months after treatment and once every 3 months after 3 months of treatment. The Kaplan-Meier method was used to calculate overall survival (OS) rate, progression-free survival (PFS) rate, and local control (LC) rate, and the incidence rates of adverse reactions and complications were also observed. Results Up to the follow-up on November 30, 2020, a total of 8 patients died, among whom 3 died of liver failure, 3 died due to tumor progression, 1 died of perforation of gallbladder, and 1 died of gastrointestinal bleeding. At 3, 6, 9, 12, and 18 months of treatment, the OS rates were 100%, 94%, 83%, 72%, and 67%, respectively, the PFS rates were 100%, 67%, 50%, 22%, and 17%, respectively, and the LC rates were 100%, 94%, 94%, 94%, and 94%, respectively; the median OS time was > 18 months, and the median PFS time was 9 months. Of all patients, 1 (6%) had a grade 3 adverse reaction during SBRT and 2 (11%) experienced a grade 3 adverse reaction during lenvatinib treatment, and no fatal adverse reaction was observed. Conclusion: It is preliminarily proved that sequential lenvatinib therapy after SBRT is an effective and safe treatment method for advanced primary liver cancer. [ABSTRACT FROM AUTHOR]

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

我国社区卫生股务中心， 儿童医疗保健工作主要由全科医生承担。但不少全科医生在基层承担儿童医疗保健 工作是心有余而力不足。该文从全科医生规范化培训中儿科轮转模式切入，分析全科医生儿科专业培训存在的问题， 主要原因是 儿科轮转时间太短，难以开展全科特色教学， 其中全科医生的儿科门诊教学是薄弱环节。建议全科医师在规范化培训全过程中要 大力倡导社区健康管理理念， 在诊疗过程中渗透预防保健和健康促进的观念， 临床带教教师要注重理论和实践教学与社区健康管 理能力相结合， 旨在探讨全科医生规范化培训中儿科轮转时间、课程设置、教学方法等， 力求增强全科医生在儿童健康领域发挥的 作用， [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的探讨纳布啡复合舒芬太尼在老年胸背部带状疱疹后神经痛患者腹部手术术后镇痛的效果。方法选择腹部手术的老年带状疱疹后神经痛患者80例,采用随机数字表法分为舒芬太尼组(A组)、纳布啡和舒芬太尼组(B组),每组各40例。两组术后均使用持续性静脉镇痛,其中A组予以舒芬太尼2μg/kg,B组予以纳布啡0.4 mg/kg+舒芬太尼1.5μg/kg,总容量均为100 mL,首次剂量2 mL,背景剂量2 mL/h,单次给药剂量3 mL,锁定时间20 min,最大剂量13 mL/h。比较两组镇痛泵自控按压次数和镇痛泵药物使用结束后至术后72 h内因腹部疼痛肌注地佐辛镇痛的人数;比较术后6、24、48 h咳嗽时、静息状态时手术切口和内脏疼痛的疼痛数字评分(NRS);比较两组术后6、24、48 h、2周、1个月、3个月胸背部带状疱疹后神经痛的NRS和疼痛增加人数,记录镇痛泵使用期间两组恶心、呕吐等不良反应发生情况。结果 B组使用静脉镇痛泵自控按压次数、72 h需肌注镇痛的人数均较A组少(P均<0.05);术后6、24、48 h,两组静息手术切口NRS、胸背部带状疱疹皮损区疼痛NRS比较差异无统计学意义(P> 0.05);咳嗽时,B组手术切口NRS和内脏疼痛NRS较A组均降低(P <0.05);在2周、1个月、3个月时,B组患胸背部带状疱疹皮损区疼痛NRS降低、疱疹疼痛加重人数增加(P <0.05);两组不良反应比较差异无统计学意义(P> 0.05)。结论纳布啡复合舒芬太尼可有效缓解老年胸背部带状疱疹后神经痛患者腹部手术术后切口和内脏疼痛,减少自控次数和追加药物镇痛次数,同时可缓解胸背部带状疱疹皮损区慢性疼痛程度与降低复发人数。 [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical effect of CyberKnife radio-surgery in locally advanced pancreatic cancer or pancreatic cancer with distant metastasis. Methods A retrospective analysis was performed for the clinical data of 32 patients with pancreatic cancer who were treated with CylierKnife radiosurgery in Trie Fifth Medical Center of Chinese PLA A General Hospital from January 2012 to April 2015. a-mong whom 9 patients received arterial infusion chemotherapy in addition. Among these 32 patients. 18 had locally advanced pancreatic cancer and 14 liad pancreatic cancer with distant metastasis ( 12 had liver metastasis. 2 had lung metastasis, and 2 liad Nine metastasis). Radiological evaluation was performed every two montlis after treatment; Response Evaluation Criteria in Solid Tumors ( RECIST) was used to evaluate local remission rate; CT - based radiological examination was used to assess the presence or absence of tumor progression; Gimmon Terminology Cri-teria for Adverse Events Version 3.0 ( CTCAE3.0) was used to analyze adverse events. Tlie Kaplan - Meier method was used to calculate overall survival time and local progression - free survival, and the log - rank test was used for the comparison of overall survival time between groups. Results Of all 32 patients. 21 had lesions in the head of the pancreas and 11 liad lesions in tlie hotly and tail of the pancreas; accord- groups. Results t)f all 32 patients, 21 had ledums in tlie liead of lln- pancreas anil 11 liaii lesions in llie hody ;iimI tail of tlie pancreas; according to pathology. 30 had adenocarcinoma and 2 had oilier pathological types; according to TNM staging. 25 hail T3 am! 7 had T4 pancreatic cancer. 23 had NO am! 9 had Nl pancreatic cancer. 18 had MO and 14 had Ml pancreatic cancer. Among lhe9 patients who were treateil with CyherKnife eomhincd with arterial infusion chemotherapy, 5 received chemotherapy via tlie gastroduodenal artery, 1 received chemotherapy via the superior mesenteric artery, and 3 received chemotherapy via tlie splenic artery. Of all 32 patients, 4(12.50% ) achieved complete remission, 18(56. 25% ) achieved partial remission, 6( 18.75% ) achieved a stahle disease, and4(12.50% ) experienced disease progression. Tlie 1 - and 2 - year overall survival rates were 43.7% and 31. 3%, respectively; tlie 1 - and 2 - year local progression - free survival rates were 87.5% and 84.4%, respectively; tlie median overall survival time was 8.5 months ( range 1 - 39 months l. The 18 patients with locally advanced pancreatic cancer had a median overall survival time of 21 months ( range 1 -36 months), and the 14 patients with pancreatic cancer with distant metastasis had a median overall survival time of 5. 5 months (range 1 - 39 months 1 . and there was no signi6cant difference between the two groups (P =0. 303 ). The 9 patients who received arterial infusion chemotherapy in addition to CyberKnife had a median overall survival time of 17 months (range 1 - 39 months) . and the 23 patients who received CyherKnife alone had a median overall survival time of 8 months (rangel -36months). and there was no significant difference between the two groups ( P =0.756). The incidence rate of grade 1 -2acute and late gastrointestinal toxicity was 78% . with major symptoms of nausea, vomiting, abdominal pain. and diarrhea. One patient experienced grade 3 late gastrointestinal toxicity manifesting as duodenal ulcer bleeding. and the bleeding was stopped by emergency intervention with a coil to block the target blood vessel. Among the 20 patients with abdominal pain or lower back pain. 12 achieved marked alleviation of pain symptoms at 2 weeks after treatment. Conclusion CyberKnife radiosurgery has a good clinical effect in the treatment of locally advanced pancreatic cancer or pancreatic cancer with distant metastasis and has few complications. [ABSTRACT FROM AUTHOR]

Copyright of Acta Automatica Sinica is the property of Chinese Academy of Sciences, Institute of Automation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the changes in natural killer(NK) cell frequency,function,and receptor expression in the peripheral blood of patients with hepatitis B cirrhosis.Methods A total of 34 patients with hepatitis B cirrhosis who were admitted to 302 Hospital of PLA from June 2013 to December 2014 were enrolled as the cirrhosis group,and 30 healthy blood donors were enrolled as the healthy control group.Flow cytometry was used to measure NK cell frequency and the expression of CD158 a,CD158b,NKG2 D,NKP30,NKP44,and NKP46 receptors in peripheral blood.Interleukin- 12(IL- 12) was used to stimulate peripheral blood mononucleated cells,and flow cytometry was used to measure the ability of NK cells to secrete interferon- γ(IFNγ) and tumor necrosis factor- α(TNFα) and analyze the killing efficiency of NK cells for K562 cells.NK cell frequency,receptor expression,and function were compared between the two groups.The t- test was used for comparison of normally distributed data between groups,and the Mann- Whitney U rank sum test was used for comparison of abnormally distributed data between groups.Results Compared with the healthy control group,the cirrhosis group had a significantly lower CD56 dimNK cell frequency(Z =- 2.309,P < 0.05) and a significantly higher CD56 brightNK cell frequency(Z = 2.395,P < 0.05).The cirrhosis group had significantly higher expression rates of NKP44 and NKP46(the activating receptors of CD56 dimNK cells) than the healthy control group(Z = 2.834 and 3.404,both P < 0.05).The cirrhosis group also had significantly higher expression rates of NKP30,NKP44,and NKP46(the receptors of CD56 brightNK cells) than the healthy control group(Z = 3.518,4.003,and 4.480,all P <0.05).After IL- 12 stimulation,compared with the healthy control group,the cirrhosis group had significantly lower expression rates of TNFα in CD56 dimNK cells and IFNγ in CD56 brightNK cells(Z =- 3.510 and- 4.301,both P < 0.05).With effector- target ratios of 3∶ 1,10∶ 1,and 30∶ 1,the cirrhosis group had significantly lower proportions of K562 cells killed by NK cells than the healthy control group(Z =- 2.355,- 2.523,and- 2.523,all P < 0.05).Conclusion The patients with liver cirrhosis experience a reduced NK cell function,which may be related to reduced frequency of CD56 dimNK cells and secretion of cytokines,but may not be related to receptor expression. [ABSTRACT FROM AUTHOR]

Copyright of Guihaia is the property of Guihaia Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To screen pepper varieties of Cd low concentration to apply in the production, pot experiments were conducted to study the transport and enrichment characteristics of Cd in typical Guizhou soil-pepper system by setting different Cd concentration. Results:( i) After harvest of pepper, Cd content was 6.11%-11.84% lower in yellow soil than in calcareous soil. When Cd content ranged from 0mg/kg to5 mg/kg, increasing trends of Cd content of pepper root and overground part were 4.1 and 1.4 times faster under the planting condition of yellow soil than calcareous soil condition respectively.( ii) In yellow soil-pepper and calcareous soil-pepper system, Cd transfer coefficients were respectively 0.04-0.25 and 0.21-0.50 from pepper root to pepper fruit. And the transfer speed was 3 times faster under the planting condition of calcareous soil than yellow soil condition. In addition, Cd enrichment characteristics were respectively 0.93-1.65 and 1.02-3.04, and the characteristics were 1.84-1.10 times higher under the planting condition of calcareous soil than yellow soil condition. In short, the transfer speed and enrichment capacity of Cd from pepper root to pepper fruit in calcareous soil was quicker than in yellow soil. Moreover, the used pepper breed initially belong to the enrichment of Cd varieties. [ABSTRACT FROM AUTHOR]

In recent years, local governments gradually increased the finance support for public welfare (nonprofit) private colleges. Since 2005, Shanghai has established "the Special funds for developing private education". The development of laboratory is one of the key fields that government finance special funds are to support private colleges. The increasing government funding also puts forward new requirements for private colleges. Private colleges must set up a sound system of internal control for managing government special funds of the development of laboratory. The system of internal control is an effective means for managing the government special fund. Based on the analysis of features of the laboratory development and special funds management in non-governmental colleges, this paper puts forward internal control processes of using special funds of the laboratory development in the private colleges and it might be as a reference for private colleges to establish internal management system. [ABSTRACT FROM AUTHOR]

Accounting laboratory is an important part of the construction of accounting major in universities. There are five ways for accounting software companies to join and support laboratory construction of accounting major in universities; 1. to provide accounting software; 2. to train experimental faculty; 3. To design teaching programs; 4. To offer internship for students; 5. To share experience about lab management. Helping universities to build professional laboratory can let enterprises to fulfill social responsibilities with their advantages. However, we have found that the social responsibility reports from accounting software companies did not make a complete disclosure about the construction of professional laboratories based on our analysis to the Yongyou corporation. Besides, accounting software companies prefer to report the constructing activities by medias, which may not only be too vague about the details, but also decrease the effect of social responsibility report. Our paper has provided feasible suggestion for accounting software companies to fulfill social responsibilities in a better gesture. [ABSTRACT FROM AUTHOR]

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的:探讨不同压强下气压弹道式体外冲击波治疗跟痛症的临床效果。方法选择跟痛症患者60例，随机分成A、B、C、D组，每组15例。四组均采用气压弹道式体外冲击波治疗仪治疗，治疗压强分别为2．5、3．0、3．5、4．0 bar，治疗频率均为1次/周，共治疗3次。四组分别于治疗前(T0)、首次治疗后即刻(T1)，末次治疗后1周(T2)、4周(T3)、12周(T4)、24周(T5)随访时行疼痛数字(NRS)评分、踝关节功能(RM)评分；分别于T0、T5时对有骨刺患者的跟骨骨刺进行CT三维重建，观察骨刺体积、长度、角度；统计治疗过程中不良反应情况。结果四组T1～T5时NRS评分和RM评分均低于同组T0时(P均<0．05)，各时间点组间NRS评分和RM 评分比较P均>0．05。四组24例有跟骨骨刺患者T0、T5时骨刺体积、长度、角度差异均无统计学意义(P均>0．05)。治疗期间C组局部肿胀1例，D组局部淤斑1例、肿胀2例，均未经特殊处理、自行恢复；A、B组未出现并发症。结论2．5～4．0 bar压强下气压弹道式体外冲击波治疗跟痛症均可缓解疼痛、促进关节功能恢复，但对骨刺无明显治疗作用。 [ABSTRACT FROM AUTHOR]

目的　探讨外源性瘦素对糖尿病大鼠呼吸机相关性肺损伤（ＶＩＬＩ）的保护机制。方法　选择Ｗｉｓｔａｒ大鼠 ４０只，取其中３０只制备２型糖尿病模型并分为Ｂ、Ｃ、Ｄ组各１０只，其余１０只未造模大鼠为Ａ组。造模后各组腹腔 注射麻醉，气管切开并插管，Ａ、Ｂ组带管自主呼吸，Ｃ组应用４０ｍＬ／ｋｇ潮气量行呼吸机机械通气４ｈ，Ｄ组经气管插 管滴注外源性重组瘦素５０μｇ／ｋｇ后，应用４０ｍＬ／ｋｇ潮气量行呼吸机机械通气４ｈ。机械通气结束后，处死各组大 鼠，取出肺脏，测定湿干比（Ｗ／Ｄ），ＨＥ染色法观察肺组织病理改变并进行病理评分，免疫组化法检测肺组织瘦素及 瘦素受体（ＯＢ-Ｒｂ）蛋白表达，ＥＬＩＳＡ法检测肺组织匀浆中白细胞介素１β（ＩＬ-１β）、髓过氧化物酶（ＭＰＯ）、巨噬细胞 炎症蛋白２（ＭＩＰ-２）及肿瘤坏死因子α（ＴＮＦ-α）水平。结果　Ｃ、Ｄ组Ｗ／Ｄ、肺组织病理评分均高于Ａ、Ｂ组，Ｄ组 Ｗ／Ｄ、肺组织病理评分、瘦素、ＯＢ-Ｒｂ蛋白表达均低于Ｃ组（Ｐ均＜０．０５）。Ｄ组肺组织匀浆中ＩＬ-１β、ＴＮＦ-α、ＭＩＰ-２、 ＭＰＯ水平及肺组织瘦素、ＯＢ-Ｒｂ表达均低于Ｃ组（Ｐ均＜０．０５）。结论　外源性瘦素预处理可明显减轻糖尿病大鼠 ＶＩＬＩ，其机制可能与抑制内源性瘦素水平及肺组织炎症反应有关。 [ABSTRACT FROM AUTHOR]