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为促进植物甾醇/谷维素油凝胶在零反式、低饱和的营养型塑性脂肪中的应用，以大豆油为基料油，植物甾醇/谷维素为凝胶剂，在不同急冷温度（5、20 ℃）及凝胶剂添加量下制备油凝胶，测定不同急冷温度及凝胶剂添加量下植物甾醇/谷维素油凝胶的晶型、晶体形态、物理稳定性、质构和热力学特性的变化。结果表明：随着凝胶剂添加量的升高，油凝胶中晶体排列逐渐致密，硬度增大，熔点升高；尽管急冷温度对油凝胶的晶型（β晶型）没有明显影响，但相对于5 ℃急冷，20 ℃急冷得到的油凝胶晶体组装更为致密，物理稳定性增强；在与传统甘三酯固脂对比SFC与硬度和熔点的关系中发现，在油凝胶体系中熔点随SFC的增加呈现非线性关系增长，但低固体脂肪含量（4.85%）即可赋予植物甾醇/谷维素油凝胶较高的硬度。综上，急冷温度及凝胶剂添加量对植物甾醇/谷维素油凝胶的物理特性具有显著的影响。 To promote the utilization of the phytosterol/oryzanol oleogels in the development of zero-trans, low saturated and nutritional plastic fats, with soybean oil as base oil, phytosterol/oryzanol as gelator, olegoels was prepared under different rapid cooling temperature(5, 20 ℃) and gelator dosages, and the changes of crystal form, crystal morphology, physical stability, texture and thermodynamic properties of phytosterol/oryzanol oleogels were investigated. The results showed that the hardness and melting point of the oleogels increased with the increase of gelator dosage, attributing to a denser arrangement of crystals. Although no obvious effect on the β crystal form of oleogels by rapid cooling temperature, the rapid cooling at 20 ℃ resulted in a denser crystals and higher physical stability compared with rapid cooling at 5 ℃. Compared with the traditional triglyceride solid fat, the relationship between SFC and hardness as well as melting point showed that the melting point increased in a non-linear with the increase of SFC in the oleogels system. Interestingly, a low SFC(4.85%) endowed a high hardness of phytosterol/oryzanol oleogels. To sum up, the rapid cooling temperature and gelator dosage have significant effect on the physical properties of phytosterol/oryzanol oleogels.

文章从理论上研究了一种应用于光纤到户（FTTH）网络中的基于单片集成的双端口光收发芯片,结合器件的结构和参数分析了该产品的直接调制特性,计算了其驰豫振荡、增益抑制和频率啁啾,得到了该器件的直接调制频率限制和频率啁啾效应下的输出光场表达式,并通过仿真分析得出了高频直接调制频率啁啾下的输出光频谱。

目的　总结白血病/骨髓增生异常综合征患者异基因造血干细胞移植术后（allo-HSCT）新型冠状病毒感 染的临床特点及预后。方法　对 53 例血液肿瘤 allo-HSCT 后感染 COVID-19 患者的临床资料作回顾性分析。结 果 53例患者中男28例（53%），女性25例（47%），中位年龄47（18～66）岁；其中急性髓系白血病25例、急性淋巴细 胞白血病21例、骨髓增生异常综合征7例；临床表现为发热36例、咳嗽34例及呼吸困难21例，36例发热患者中37. 3～ 38 ℃者6例、38. 1～39 ℃者25例、39. 1～41 ℃者4例、>41 ℃者1例，34例咳嗽患者中轻度25例、中度6例、重度3例； 胸部X线检查可见肺外带多发小斑片影及间质改变47例；新型冠状病毒感染临床分型为轻型15例、中型29例及重 型9例。53例患者均予抗病毒药物、糖皮质激素治疗，其中19例同时输注康复者恢复期血浆、34例同时予白细胞介 素 6（IL-6）抑制剂治疗。53例患者治疗后痊愈 49例、死亡 4例。与痊愈患者相比，死亡患者的合并其他病原体感 染比例、疾病处于进展状态及合并移植物抗宿主病比例高（P 均<0. 05）。结论 allo-HSCT 术后新型冠状病毒 感染患者常表现为低热及轻度咳嗽。合并其他病原体感染比例、疾病处于进展状态及合并移植物抗宿主病的 allo-HSCT术后新型冠状病毒感染患者的预后较差。 [ABSTRACT FROM AUTHOR]

To cultivate high-quality, research-oriented, innovative talents, significant efforts have been made to develop the course resources and reform the teaching models for the graduate course “Elemental Inorganic Chemistry”. Key initiatives include reconstructing a hierarchical knowledge framework, developing multi-dimensional course resources, promoting blended teaching that combines online and offline elements, implementing comprehensive multi-dimensional assessments, and deeply integrating ideological education into the curriculum. These measures have enhanced students’ capabilities in independent learning, knowledge expansion, and interactive learning. The integrated approach of imparting knowledge, cultivating skills, and leading values has successfully raised students' overall competencies and capabilities for scientific innovation. [ABSTRACT FROM AUTHOR]

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Central retinal artery occlusion (CRAO) is a vascular neuro-ophthalmic emergency, characterized by acute painless monocular vision loss, which is one of the main causes of blindness in middle-aged and elderly people. Currently, the pathogenesis and pathophysiological mechanism of CRAO is unclear, making the selection of appropriate animal models particularly important for the research on CRAO pathogenesis and the screening of therapeutic drugs. This paper mainly reviews the modeling methods and research progress of CRAO animal models, aiming to provide a reference basis for accurate diagnosis and treatment of CRAO. [ABSTRACT FROM AUTHOR]

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Distant supervision relation extraction uses the automatic alignment of natural language texts and knowledge bases to generate labeled training datasets, solving the problem of manual sample labeling. In the current research, most distant supervision does not pay attention to the long-tail data, so most of the sentence bags obtained by distant supervision contain too few sentences. These sentence bags cannot truly and comprehensively express the data itself. This paper proposes a distant supervised relation extraction model (PG+PTATT) based on position-type attention mechanism and graph convolutional network. According to the similarity between sentence bags, Graph Convolutional Networks (GCN) aggregate the implicit high-level features of similar sentence bags to optimize the sentence bags and obtain more prosperous and more comprehensive feature information of the sentence bags. At the same time, an attention mechanism, Position-Type Attention (PTATT) is constructed, which can solve the problem of wrong labels in distant supervision relation extraction: using the position relationships between entity words and non-entity words and type relationships are modeled to reduce the impact of noisy words. The proposed model is experimentally verified on the dataset New York Times (NYT), and the experimental results show that the proposed model can effectively solve the problems existing in distant supervision relation extraction; and it can effectively improve the accuracy of relation extraction.. [ABSTRACT FROM AUTHOR]

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Objective: To develop the College Students’ Self-Expectation Questionnaire (CSSEQ) and test its validity and reliability. Methods: Combined with the structured interviews and literature analysis, the structural model of college students’ self-expectation was constructed and the preliminary questionnaire was compiled. Totally 400 college students were selected for item analysis and exploratory factor analysis, and 375 of them were selected for criterion related validity test. In addition, 739 college students were selected for confirmatory factor analysis and internal consistency reliability test, and 122 of them were retested one month later. The Achievement Motivation Scale (AMS) and Subjective Well-Being Scale (SWBS)were used to test the validity of the criterion. Results: The questionnaire contained 19 items, including 5 dimensions (academic performance, career development, physical and mental health, personality quality and social orientation), which explained 66. 79% of the variance variation. The factor load of each item rangedfrom 0. 61 to 0. 86. Confirmatory factor analysis showed that the 5 factor structure model fitted well (χ²/df=4. 32, GFI=0. 92, CFI=0. 95, IFI=0. 95, TLI=0. 94, RMSEA=0. 07). The CSSEQ total scores and the scores of each factor were positively correlated with the total scores of AMS and SWBS (ICC=0. 18-0. 64. P. s ＜0. 01). The Cronbach’s α coefficients of the total questionnaire and the 5 factors ranged 0. 77 to0. 95, and the test-retest reliabilities ranged 0. 71 to 0. 89. Conclusion: The College Students’ Self Expectation Questionnaire (CSSEQ)has good validity and reliability. [ABSTRACT FROM AUTHOR]

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Objective To discuss the value of 18F-FDG PET/CT combined with serum CA19-9, CEA and NSE in the differential diagnosis pancreatic ductal adenocarcinoma（pDAC） and pancreatic neuroendocrine tumors （pNETs）. Methods Retrospective analys is of patients who were diagnosed as pDAC or pNETs by pathology, including the clinical data, 18F-FDG PET/CT images and the level of tumor markers CA19-9, CEA and NSE, and compared age, sex, size and location of the lesions, the involvement of pancreatic ductal, the morphology of the lesionson PET image, SUVmax, surrounding lymphatic metastasis and hepatic metastasis and the level of serum CA19-9, CEA, NSE between the two groups, and figure out the effective indicators in differential diagnosis. The diagnostic efficacy of 18F-FDG PET/CT imaging SUVmax combined with serum CA19-9, CEA and NSE was compared. Results There were 74 patients were included. The age were between 46 and 82（66.48 ± 8.84）, and 32 were male, 32 were female. 46 patients were pDAC, 28 were pNETs. The mean value of SUVmax were （5.55 ± 2.01） in pDAC group, （4.62 ± 2.01） in pNETs group. It was not statistically significant between the two groups in sex, morphology of the lesions in PET image, SUVmax, surrounding lymphatic metastasis（P > 0.05）, and was statistically significant in age, size of the lesions, location of the lesions, the involvement of pancreatic ductal hepatic metastasis and serum CA19-9, CEA, NSE（P < 0.05）. The diagnostic efficacy of SUVmax combined with serum CA19-9, CEA and NSE was improved compared with SUVmax, which SUVmax combined with CA19-9 had the best diagnostic efficacy with the AUC of ROC curve was 0.891（ 95%CI: 0.816～0.967, P < 0.001）. Conclusion The using of 18F-FDG PET/CT combined with serum CA19-9, CEA, NSE has a high differential diagnosis value in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine tumors, that make up the shortage of using 18F-FDG PET/CT alone, which the diagnostic efficiency of SUVmax combined with CA19-9 was the best. [ABSTRACT FROM AUTHOR]

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Objective To investigate the motor ability and skeletal muscle pathology in mice with Duch- enne muscular dystrophy (DMD) and to explore the therapeutic effects of Deflazacort on DMD. Methods Ten - weeks-old transgenic DMD mice were selected and randomly divided into normal control group, model group and Deflazacort - treated group according to their body weights, seven in each group. The mice in all groups were weighed once a week for an experimental period of 8 weeks. At 10, 14 and 18 weeks of age, the mice were assessed for locomotor activity by hanging test, pole climbing test and grip strength test, and at 18 weeks of age, the mice were observed for changes in limb stride distance, followed by testing their walking speeds by gait test. After eutha- nasia, muscle lesions were assessed by measuring serum creatine kinase, lactate dehydrogenase, muscle pathology histology and morphological analysis. Results Compared to the DMD mice, there were no significant changes in body weight in Deflazacort -treated mice, but the suspension time was prolonged (P < 0.05), the pole climbing elapsed time reduced (P < 0.01), the forelimb grip increased (P < 0.05), and the stride distance and walking speed both increased (P < 0.01). Meanwhile, the serum creatine kinase values were lowered, and the areas of skeletal muscle inflammatory cell infiltration (P < 0.01) and fibrosis were reduced. Conclusion Deflazacort is effective in treating hypokinesia, gait bradykinesia and skeletal muscle inflammatory damage in mice with DMD. [ABSTRACT FROM AUTHOR]

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