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目的探索本中心使用促性腺激素释放激素拮抗剂（GnRH-ant）方案促排后新鲜单囊胚移植患者妊娠失败的独立危险因素。方法回顾性分析2017年1月至2020年4月在中山大学附属第三医院生殖医学中心行助孕治疗的325个治疗周期的资料。根据妊娠结局分为临床妊娠组（172例）和未妊娠组（153例），比较两组患者间的基础资料，临床促排卵情况，胚胎发育情况，移植囊胚的分期、内细胞团（ICM）和滋养外胚层（TE）评分，将P＜0.1的变量纳入回归方程进行多因素Logistic回归分析，找出临床妊娠失败的独立危险因素。结果两组患者间的基础资料差异无统计学意义，促性腺激素（Gn）使用天数（8.9±1.3 vs. 8.6±1.2）、人绒毛膜促性腺激素（HCG）注射日的卵泡刺激素（FSH）水平（12.1±3.7 vs. 13.0±4.0）U/L、受精方式及移植囊胚的 ICM和TE评分在临床妊娠组和未妊娠组的差异有统计学意义。将P＜0.1的变量即不孕类型、受精方式、Gn使用天数、HCG注射日FSH水平、HCG注射日黄体生成素（LH）水平和移植囊胚的ICM和TE评分纳入回归模型，采用逐步法分析后发现临床妊娠失败的独立危险因素是移植囊胚的TE评分［P=0.001，OR=2.173，95%CI：（1.359，3.476）］、Gn使用时间［P=0.015，OR=0.794，95%CI：（0.659，0.955）］和受精方式［P=0.024，OR=2.065，95%CI：（1.098，3.882）］。结论本中心的数据提示≤40岁预后良好的患者使用拮抗剂促排并行新鲜单囊胚移植时，较差的滋养外胚层评分，较短的Gn使用时间和使用ICSI受精方式是临床妊娠失败的独立危险因素。

为准确评估既设光缆未来任务时间是否适用于高性能光端传输设备,提出一种基于传输性能指标预测的光缆可用性评估方法。在构建组合模型准确预测光缆性能指标的基础上,根据光端设备对线路允许损耗变化范围的要求评估光缆的可用性。通过实例验证说明了基于性能指标预测的光缆可用性评估方法的准确性和有效性,对解决光缆可用性评估问题具有一定的参考价值和指导意义。

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Shuowen Jiezi defines “Mi (糸)” as “a fine thread, resembling the form of a bundle of threads, and all things related to ‘Mi (糸)’ derive from ‘Mi (糸)’”. More commonly, scholars lean toward this explanation, believing “Mi (糸)” refers to either the single fiber extracted from the silkworm cocoon or recognizing the early symbol of “Mi (糸)” as “si(丝)” (silk). However, this fails to explain the three pairs of contradictions of why the appearance of the character “糸” (BP 7100) is earlier than the utilization of silk (BP 6000), the deviation between the pictographic features of “Mi (糸)” is inconsistent with the morphology of a silk, and the existence of enormous Mi (糸)-series words unrelated or not only related to silk. Reconsidering the meaning of “Mi (糸)” based on its ancient script images, meaning in ancient texts, and archaeological timelines aids in understanding the evolutionary patterns of Chinese characters, comprehending the societal development of that time more accurately, and delving into cultural insights. The article employed textual analysis, textile archaeology, and statistical deductions to investigate the meaning of “Mi (糸) ” and drew three significant conclusions.First, the meaning of “Mi (糸) ”should not be limited to silk. On the timeline, the appearance of the character “Mi (糸) ” occurred at least 1 100 years earlier than the speculated use of silk found in the excavated “half cocoon” from Xiyin village, and nearly 4 000 years earlier than the appearance of the character “Si (丝)”. On pictographic features, “Mi (糸) ” has consistently depicted multiple(2–3) intertwining threads from ancient times to the present, which does not correspond to the clustered morphology of silk and raw silk. In ancient documents, among the 250 characters cataloged under the Mi (糸)-series in Shuowen Jiezi, fewer have explicit definitions related to silk than those unrelated. Furthermore, the remaining 70.0% of characters are related to textiles and their products, yet the specific fiber source is unspecified. Thus, the original meaning of “Mi (糸) ” does not signify silk. Second, the word “Mi (糸) ” is more consistent with the structure and making method of ropes and threads, i.e. twisting- or braiding-formed textiles in terms of temporal logic and historical existence. Archaeological evidence indicated the use of ropes for various purposes (BP 1 000 000 to 20 000), which preceded the appearance of “Mi (糸)” (BP 7 300 to 7 100) and silk (BP 6 000). Third, it is more appropriate, objective, and consistent with historical facts to define “Mi (糸)” as threads, ropes, or twisted bundles of fibers rather than silk. Previous research mainly focused on characters under the Mi (糸)-series, with less exploration into the original meaning of “Mi (糸) ” . The article presents three contradictions in interpreting “Mi (糸)” as silk. It systematically and comprehensively collects, organizes, and analyzes the differences and similarities between “Mi (糸)” and silk based on its ancient script images, meaning in ancient texts, and archaeological timelines, proposes the original meaning of “Mi (糸)” as a continuous, elongated material formed by twisting fibers and validates this conclusion through textile archaeological evidence. In the future, it will be possible to further explore the original meaning of “Mi (糸)” by examining specific contexts of its ancient usage. [ABSTRACT FROM AUTHOR]

Objective To explore the application of multi-model teaching in improving the quality and efficiency of training in neurointerventional operation for ischemic cerebrovascular disease. Methods Subjects were selected as training doctors who received cerebrovascular interventional operation training in the Department of Neurology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School from January 2018 to December 2022. All training doctors received multi-model training, that is, a combination of multiple teaching methods and cross-training mode for teaching. Questionnaire survey was used to evaluate the training doctors’ satisfaction of multi-model teaching and the changes in theoretical knowledge and practical ability of intervention diagnosis and treatment before and after training. Results A total of 55 training doctors were included, aged from 32 to 50 years, including 51 males (92.73%). Among them, 89.09% were satisfied with the multi-model teaching. Meanwhile, 83.64% and 85.45% of training doctors believe that multi-model teaching has stimulated their learning interest and improved self-learning abilities, respectively. After training, a significant increase in the number of training doctors who can independently complete extracranial stent implantation was achieved (41.82% vs. 12.73%, P=0.001). Conclusions The muti-model teaching is an effective method to improve the quality and efficiency of training in neurointerventional operation for ischemic cerebrovascular disease. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Highly weathered granite is widely distributed in the southeast coast of China. During the construction of large-diameter rock-socketed monopile for offshore wind power in the strongly weathered granite formation, hole wall instability becomes a common phenomenon. For this reason, the elastic-plasticity constitutive model, which can describe the structural and over-consolidation properties of the strongly weathered granite, was embedded into the finite element software ABAQUS through the subroutine UMAT. The parameters of the constitutive model were determined based on the results of geotechnical tests. On this basis, numerical model of hole wall stability was established, and the development law of pore wall instability and its influencing factors were analyzed. The research results show that the soil around the hole wall reaches a critical state due to the unloading stress, which is the main reason for the collapse of the hole. The range of the collapsed hole increases with the increase of the hole diameter and pile length, and the ratio of the maximum collapsed hole radius to the pile diameter ranges from 0.5 to 0.7. [ABSTRACT FROM AUTHOR]

Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Mitochondria are highly dynamic organelles that go through biogenesis, division, fusion, and mitochondrial autophagy. This process refers to mitochondrial dynamics. Evidence from numerous studies suggests that imbalance in mitochondrial dynamics is closely associated with the development of bone-related diseases. Modulation of mitochondrial dynamics may help to provide new ways for prevention and treatment strategy of bone-related diseases. Therefore, this paper reviews the latest research progress in mitochondrial dynamics and bone-related diseases, hoping to provide new ideas for the treatment of bone-related diseases with the aspect of mitochondrial dynamics. [ABSTRACT FROM AUTHOR]

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