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Objective To design a non-invasive non-contact physiological parameters monitoring system to realize physiological status real-time monitoring. Methods The system was developed with Arduino hardware and its integrated development environment, high-precision high-sensitivity GY-MCU90615 infrared thermometric module and Si1143 heart rate and blood oximeter module, which was composed of five parts of physiological parameters acquisition, development platform, COM port transmission, network transmission and data terminal. Results The desired requirements were met by continuous, non - invasive, non-contact and accurate monitoring of body temperature, oxygen saturation and heart rate. Conclusion The system gains advantages in design and convenience, and thus is worthy promoting for physiological parameters monitoring in the hospital, geracomium and home. [ABSTRACT FROM AUTHOR]