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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the optimal cut-off value of alpha-fetoprotein (AFP) in the diagnosis and early screening of hepatocellular carcinoma (HCC). MethodsThe clinical data of 2212 HCC patients who were diagnosed and hospitalized in our hospital and 1998 non-HCC patients were collected, and the AFP level was summarized. The AFP level was divided into 10 ranges of 10-20 μg/L, 21-65 μg/L, 66-110 μg/L, 111-155 μg/L, 156-200 μg/L, 201-250 μg/L, 251-300 μg/L, 301-350 μg/L, 351-400 μg/L, and ＞400 μg/L, and a comparative analysis was performed for the sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of each cut-off value of AFP, ultrasound, and their combination in the diagnosis of HCC. The receiver operating characteristic (ROC) curve was plotted to determine the optimal cut-off value. ResultsThe cut-off valve of AFP of 200-250 μg/L had the largest sum of sensitivity and specificity (1.370 1) and the largest area under the ROC curve (0.896 4). AFP ＞20 μg/L combined with ultrasound had the highest sensitivity (95.35%) in the diagnosis of HCC, with a diagnostic odds ratio of 26.13. ConclusionThe optimal cut-off value of AFP in the diagnosis of HCC is 200 μg/L. When AFP combined with ultrasound is used for the screening of people at a high risk of HCC, AFP＞20 μg/L is recommended as a positive index, and its combination with differential diagnosis and close follow-up and examinations can reduce the false negative rate of screening. [ABSTRACT FROM AUTHOR]

Objective To summarize the clinical experience in laparoscopic hepatectomy in the treatment of hepatocellular carcinoma (HCC). MethodsThe patients with HCC who were admitted to Huaian No. 1 People′s Hospital Affiliated to Nanjing Medical University, Drum Tower Hospital Affiliated to Nanjing University, and The Affiliated Hospital of Xuzhou Medical Hospital from December 2008 to December 2015 were enrolled and their clinical data were collected. According to the surgical procedure, these patients were divided into laparoscopic hepatectomy group with 391 patients (LH group) and open hepatectomy group with 682 patients (OR group). The two groups were compared in terms of time of operation, incision size, intraoperative blood loss, postoperative recovery, length of postoperative hospital stay, surgery costs, hospital costs, and complications. The independent samples t-test was used for comparison of continuous data between two groups, and the chi-square test was used for comparison of categorical data between two groups. ResultsThere were significant differences between the LH group and the OR group in intraoperative blood loss (165.00±79.21 ml vs 457.00±125.00 ml, t=41.64, P＜0.05), length of incision (4.07±0.31 cm vs 20.48±2.36 cm, t=136.80, P＜0.05), time to diet (1.50±0.61 d vs 2.43±0.40 d, t=30.10, P＜0.05), time to ambulation after surgery (1.36±0.31 d vs 4.12+0.82 d, t=63.98, P＜0.05), length of hospital stay (10.09±3.52 d vs 15.36±4.57 d, t=19.70, P＜0.05), surgery costs (9471.00±639.73 yuan vs 5329.12±461.40 yuan, t=122.44, P＜0.05), and hospital costs (37 315.17±13 194.78 yuan vs 35 007.6±10 611.20 yuan, t=3.13, P＜0.05). The 1-, 3-, and 5-year survival rates were 89.42%, 64.32%, and 43.12% in the LH group and 88.11%, 61.45%, and 38.38% in the OR group, and there were no significant differences between the two groups (P＞0.05). ConclusionLH has the advantages of little trauma, low intraoperative blood loss, fast recovery, and short postoperative hospital stay and does not increase complications. Therefore, it can be used as the primary therapy for peripheral liver cancer, small hepatocellular carcinoma, and liver tumor in the left lateral lobe. [ABSTRACT FROM AUTHOR]