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Objective: To analyze the expression significance of serum total bile acid(TBA), intercellular adhesion molecule-1 (ICAM-1) and total bilirubin (TBIL) in pregnant women with cholestasis of pregnancy and their predictive value for fetal distress. Methods: 120 pregnant women with cholestasis of pregnancy admitted to our hospital from March 2022 to October 2023 were selected as the observation group. According to the severity of the disease, they were further divided into mild group(72 cases) and severe group(48 cases). Another 120 normal pregnant women were selected as control group. The expression levels of serum TBA, ICAM-1 and TBIL were detected in all pregnant women, and the relationship between serum TBA, ICAM-1 and TBIL and liver function indexes (ALT, AST, gamma-glutamyl transpeptidyase) was analyzed. Receiver operating characteristic curve (ROC) was used to analyze the predictive efficacy of serum TBA, ICAM-1 and TBIL in fetal distress. Results: The expression levels of serum TBA,ICAM-1 and TBIL in observation group were higher than those in control group(P<0.05). The expression levels of serum TBA, ICAM-1 and TBIL in severe group were higher than those in mild group (P<0.05). The expression levels of ALT, AST and γ-GT in serum of observation group were higher than those of control group (P<0.05). By Pearson correlation analysis, the expression levels of serum TBA, ICAM-1 and TBIL were positively correlated with liver function indexes (ALT, AST, gamma-GT) in pregnant women with cholestasis of pregnancy (P<0.05). According to ROC curve analysis, the sensitivity of serum TBA, ICAM-1 combined with TBIL in predicting the occurrence of fetal distress in pregnant women with cholestasis of pregnancy was 91.42%, the specificity was 54.83%, and the AUC was 0.921, which was higher than the AUC of single index (P<0.05). Conclusion: The expression levels of serum TBA, ICAM-1 and TBIL in pregnant women with cholestasis of pregnancy are significantly increased, which is related to the severity of the disease, and the combined prediction of fetal distress is better. [ABSTRACT FROM AUTHOR]

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