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To explore the influencing factors of respiratory function exercise behavior in patients with chronic obstructive pulmonary disease (COPD), and to construct a nomogram prediction model. 112 COPD patients in our hospital from March 2021 to March 2023 were selected, and patients were divided into low compliance group (n=68) and high compliance group (n=44) according to their respiratory function exercise behavior. The influencing factors of low compliance of respiratory function exercise behavior in COPD patients were analyzed by univariate analysis and multivariate logistic regression analysis, and a prediction model was constructed, the predictive value of the model was analyzed by receiver operating characteristic (ROC). Age≥ 60 years old, on the job, no family support, dyspnea after activity, high disease uncertainty, and low exercise self-efficacy were independent risk factors for low compliance of respiratory function exercise in COPD patients (P<0.05). The area under the curve (AUC) of age, on the job, family support, dyspnea after activity, disease uncertainty, exercise self-efficacy and nomogram prediction model were 0.645, 0.645, 0.717, 0.600, 0.660, 0.672 and 0.908 respectively, the prediction model had higher predictive value for low compliance of respiratory function exercise in COPD patients, when the cut-off value was 0.498, the sensitivity was 0.912 and the specificity was 0.795. The internal validation of the Bootstrap method (B=1000) showed that the predicted curve after the correction of the deviation was basically coincident with the ideal line, and the consistency index (C-index) was 0.816, indicating that the prediction ability of the model was better. The decision curve shows that the threshold probability range was 0.01~0.92, and the net return rate was>0. Age≥ 60 years old, on the job, no family support, dyspnea after activity, high uncertainty of disease, and low exercise self-efficacy are independent risk factors for low compliance of respiratory function exercise in COPD patients. The predictive model can help to assess exercise compliance and develop interventions. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Liquid Crystal & Displays is the property of Chinese Journal of Liquid Crystal & Displays and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Liquid Crystal & Displays is the property of Chinese Journal of Liquid Crystal & Displays and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的建立一种烟熏诱导的慢性阻塞性肺疾病(COPD)小鼠模型,并对其进行验证。方法将32只C57BL/6小鼠随机分为正常组、烟熏2周组、烟熏4周组、恢复组,各8只。正常组不予烟熏,烟熏2、4周组及恢复组置于熏烟箱中,被动吸烟6支/次,每次1 h;两次间隔30 min呼吸新鲜空气,4次/d,5 d/周。烟熏2周组第10天停止吸烟,烟熏4周组第26天停止吸烟,恢复组烟熏4周后再正常饲养2周。观察各组一般情况及体质量变化,测定支气管肺泡灌洗液(BALF)中蛋白含量;取肺组织制备切片,HE染色观察病理形态变化及肺泡直径。结果建模开始后正常组体质量呈上升趋势,烟熏2、4周组及恢复组出现精神萎靡、食欲降低,体质量较同时间点正常组降低(P均<0.01);恢复组停止烟熏后体质量缓慢上升,但仍低于正常组(P均<0.05)。BALF蛋白含量:烟熏2、4周组及恢复组均明显高于正常组(P均<0.01);烟熏4周组及恢复组明显高于烟熏2周组,恢复组明显低于烟熏4周组(P均<0.01)。肺组织病理形态学显示,正常组肺组织有少量淋巴细胞,肺泡结构完整;烟熏2周组有少量中性粒细胞、大量单核细胞及淋巴细胞浸润,肺泡扩大,部分肺泡间隔断裂并融合;烟熏4周组肺组织伴有少量中性粒细胞浸润,单核细胞及淋巴细胞浸润较烟熏2周组明显增多;支气管上皮细胞变性、坏死脱落,部分肺泡间隔变窄、断裂并融合成肺大疱。肺泡直径:烟熏2、4周组及恢复组均大于正常组,烟熏4周组及恢复组均大于烟熏2周组(P均<0.01),烟熏4周组与恢复组比较差异无统计学意义(P>0.05)。结论单纯烟熏4周法成功制备COPD小鼠模型;该模型符合人类COPD的病理和功能改变,是进行COPD动物实验的理想建模方法。 [ABSTRACT FROM AUTHOR]

Copyright of Rock & Mineral Analysis is the property of Editorial Board of Rock & Mineral Analysis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)