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以某奥体中心体育场钢结构屋盖为研究对象，对其加固及施工方案进行了分析。首先进行模型反建，并对该屋盖在施加新增荷载后的内力及变形进行分析，明确了需要加固的杆件范围。在此基础上，采用有限元软件对结构开展精细化分析，确定了包含加强节点、杆件和结构的加固方案，有效地改善了结构的传力体系，提高了结构的承载能力并降低了结构在使用荷载下的应力和变形。针对钢屋盖的不同部位，分别通过预应力锚索、增大截面和设置刚性圆管等方式进行加固，保证结构安全且满足建筑要求。除此之外，还对该加固方案对应的施工过程进行了有限元模拟，可为实际施工提供参考。经省运会工程实践验证，本项目的加固方法简单有效。

目的基于简单易得的临床资料，开发并验证２型糖尿病（T2DM）患者并发威胁视力的视网膜病变（VTDR）的风险预测模型，为基层医院提供便捷有效的预测工具，以便早期识别和转诊高危人群。方法使用2017年至2020年广州糖尿病眼病研究中T2DM患者临床数据构建列线图预测模型。使用Logistic回归分析VTDR的影响因素并建立模型，受试者工作特征曲线（ROC）、Hosmer-Lemeshow检验、校准曲线、决策曲线（DCA）用于评价模型的性能。使用k折交叉验证得到的平均ROC下面积对模型进行内部验证，使用东莞眼科研究数据对模型进行外部验证。结果建模集共纳入患者2 161例，并发VTDR者135例（6.25%）。年龄（P＜0.001，OR=0.927，95%CI：0.898~0.957）、体质量指数（P＜0.001，OR =0.845，95%CI：0.821~0.932）与VTDR负相关，糖尿病病程（P＜0.001，OR=1.064，95%CI：1.035~1.094）、是否使用胰岛素（P =0.045，OR =1.534，95%CI：1.010~2.332）、收缩压（P＜0.001，OR =1.019，95%CI：1.008~1.029）、糖化血红蛋白（P＜0.001，OR =1.484，95%CI：1.341~1.643）和血清肌酐（P＜0.001，OR =1.017，95%CI：1.010~1.023）与VTDR正相关，均被纳入模型。ROC提示建模集和验证集中该模型预测VTDR发生的曲线下面积分别为0.797和0.762；Hosmer-Lemeshow检验（P＞0.05）及校准曲线表明预测概率与观测概率具有较高一致性；DCA表明模型在建模集和验证集中均能产生净效益。结论年龄、糖尿病病程、是否使用胰岛素、体质量指数、收缩压、糖化血红蛋白和血清肌酐是VTDR的独立影响因素，基于上述变量构建的列线图模型有良好的预测效力，可以为基层医院早期识别和转诊VTDR提供科学依据，值得应用推广。

建立圆形、正方形、圆端形、六边形钢管混凝土柱在火灾下的有限元模型,利用现有试验结果验证有限元模型。基于该模型,研究保护层种类、保护层厚度、截面形状和截面周长等参数对钢管混凝土柱耐火极限的影响。分析表明,试件耐火极限随着保护层厚度和截面周长的增加而增大。厚涂型涂料的防火效果优于砂浆的防火效果。在长细比和截面周长相同的情况下,圆端形钢管混凝土柱的耐火极限高于圆形钢管混凝土柱;六边形钢管混凝土柱的耐火极限优于方钢管混凝土柱;绕强轴破坏的耐火极限略低于绕弱轴破坏的情况。基于周长等效原则,可将圆端形(或六边形)钢管混凝土柱视为圆形(或正方形)钢管混凝土柱进行抗火设计。

四轴飞行器控制活动杆件或装水酒杯平衡是一项难度系数极大的任务，所构成的模型称为四轴飞行器—倒立摆不倒平衡控制系统。基于这种特殊形式的倒立摆不倒平衡控制模型，在X-Z平面简化为线性不倒模型进行分析，建立其动力学模型，并结合滑模控制的算法，设计系统的控制器并进行仿真实验。利用滑模控制算法对四轴飞行器—倒立摆不倒平衡控制系统进行控制，实验结果表明，其表现出了优异的不倒稳定性。

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The incidence of malignant tumors has steadily increased year by year in China in recent decades. The emergence of innovative anti-cancer drugs has bolstered the prognosis of cancer patients, making it a chronic disease. Kidney injuries are frequent complications of cancer treatment clinically manifested as acute kidney injury (AKI), chronic kidney disease (CKD), proteinuria, and electrolyte disorders, etc. Although kidney injuries affect up to 50% of the patients, there is a lack of professional management guidance for anti-cancer drug dosage adjustment. The clinical pharmacology branch of the Chinese Medical Association has initiated the "Chinese expert consensus on the guidance of anti-tumor drugs for patients with tumor combined chronic kidney disease (2024 edition)". We unified national multidisciplinary experts to analyze clinical evidence with the Delphi method, and conducted expert interviews and seminars focusing on kidney function assessment, anti-tumor drug dosage adjustment for kidney disease patients. We make recommendations on selection and dose adjustment of anti-tumor drugs (chemotherapy, small molecules and antibodies) according to chemotherapeutic drug classifications, providing practical and feasible scientific guidance for clinicians. [ABSTRACT FROM AUTHOR]

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