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目的基于多组学技术，探讨地塞米松（Dex）能否通过调节肠道菌群及代谢物治疗肺炎。方法将18只Sprague-Dawley大鼠随机均分为对照（Control）组、模型（Model）组和地塞米松（Dex）组，每组6只，除Control组外，余下两组持续使用4 mg/kg的脂多糖（LPS）腹腔注射7 d建立大鼠肺炎模型。然后Dex组给予2 mg/kg的Dex灌胃治疗12 d，余下两组均连续灌胃等量的无菌PBS缓冲液12 d。第19 d时收集大鼠的肺组织、血浆、粪便和肠道内容物。苏木精-伊红（H&E）染色和Bio-plex悬浮芯片系统评价Dex的药效。宏基因组测序和超高效液相色谱串联四极杆飞行时间高分辨率质谱（UPLC-Q-TOF-MS/MS）技术分别测定大鼠的肠道菌群和代谢物。结果H&E染色结果显示Model组大鼠肺组织炎症细胞浸润增加，肺泡间隔增大，肺泡出血，给予Dex治疗后肺组织病变得以缓解。与Control组相比，Model组中的3种炎症因子TNF-α（P < 0.000 1）、IL-1α（P = 0.009 6）和IL-6（P < 0.000 1）含量升高，Dex治疗后能降低3种炎症因子水平。综上所述，Dex给药能有效的缓解肺炎大鼠的症状。宏基因组分析表明3组大鼠的肠道菌群结构改变，与Model组相比，Dex组厚壁菌门的相对丰度升高，厚壁菌门/拟杆菌门比例增加，双歧杆菌科、毛螺菌科和乳酸杆菌科积累。多变量统计分析显示Model组和Dex组极大的分离，揭示代谢轮廓改变。此外，Model组与Dex组筛选出69个（P < 0.05）差异代谢物，包括Model组中上调的38个代谢物和Dex组上调的31个代谢物，这些差异代谢物主要参与了亚油酸代谢、色氨酸代谢和初级胆汁酸生物合成这3条代谢通路。结论我们证明了Dex对肺炎大鼠的有益作用，与此同时，宏基因组学联用UPLC-Q-TOF-MS/MS非靶标代谢组学，揭示了Dex通过调节肠道菌群和宿主代谢物治疗LPS诱导的大鼠肺炎，本研究可能为Dex治疗大鼠肺炎的作用机制提供新见解。

目的 探索空腹血糖对无症状颈动脉粥样硬化斑块患者认知功能的影响。 方法 研究人群为2015年9月-2017年9月期间参与中国国家脑卒中高危人群筛查和干预（China national stroke screen survey，CNSSS）项目，北京市昌平区北七家社区卫生服务中心和北京市顺义区空港医院筛查点的40岁以上非城镇居民。入组标准为既往无脑血管疾病及相关神经功能缺损症状和体征，且行超声检查确诊存在颈动脉粥样硬化斑块。采用MoCA量表（北京版）评价认知功能。采用多因素logistic回归分析空腹血糖与认知障碍（MoCA

光与纳米结构的相互作用一直是纳米光子学的重要研究内容之一,核心部件的纳米结构对光子器件的功能和性能具有决定性作用。纳米光子器件的设计存在两种思路:一是从物理原理出发的直观设计;二是根据所需光学响应探索最优结构的逆设计。近年来,逆设计在纳米器件中取得了一系列重要进展,尤其是最近将深度学习方法引入进来,开启了高性能纳米光子器件智能高效设计的新篇章。文章围绕纳米光子器件智能逆设计方法,分析归纳了这一新兴研究方向的产生背景、重要进展和典型应用,对智能逆设计面临的挑战及未来发展方向进行了展望。

文章设计了一种超小的硅基多波长路由器,它可实现光通信窗口多波长的路由功能。首先用平面波展（PWG）方法分析了这种光路由的理论及其结构特性,然后用时域有限差分（FDTD）方法数值模拟了该类器件的导光波特性及光场能量传播特性。所设计的硅基多波长路由器具有透射效率高和整体尺寸超小（总长度在20μm左右）的特点,能同时实现1.31、1.55和1.65μm光波长的路由功能。

针对大规模多输入多输出系统的各小区复用相同导频序列进行信道估计存在严重导频污染的问题,提出了一种改进的信道估计算法用以减轻导频污染。该方法用随机导频序列替代各小区复用的相同导频序列用于信道估计,由于随机导频具有独立不相关的特性,因而用于信道估计时具有使信道状态信息获取更加准确、导频污染很小的优点。对信道估计均方误差的性能进行了仿真,仿真结果表明,改进的算法可以较明显地减轻导频污染对信道估计的影响。

目的 探讨定期文献报告会在血管神经病学研究生临床教学中的效果。 方法 选取首都医科大学附属北京天坛医院神经病学中心血管神经病学科2病区的临床实习轮转研 究生，开展定期文献报告会，最终评价教学效果。 结果 研究生的文献阅读量明显增加，查阅文献、归纳整理文献的能力、临床专业知识及制作幻灯、 表达交流能力均有了很大提高，能够更好地发现和解决临床问题，临床教学效果良好。 结论 定期文献报告会对提高学生临床能力、科研能力及表达能力有重要意义，值得推广。 Abstract: Objective To investigate the effect of regular literature review seminar in teaching of vascular neurology for postgraduates. Methods Postgraduate students in vascular neurology center of Beijing Tiantan Hospital, Capital Medical University participated in this study, who attended regular literature review seminar. Teaching effect was evaluated after one semester. Results Regular literature review seminar promoted an improvement of postgraduates’ various ability: the quantity and quality of literature reading, literature content extraction, and the ability of expression and communication; moreover, it also solidified students’ professional knowledge, and enhanced their ability of discovering and solving clinical problems. Conclusions Regular literature review seminar can help postgraduate students understand professional knowledge more deeply and comprehensively, broaden their horizon in professional field. This method is worthy of popularization in postgraduates teaching.

： 【目的】探讨肝癌患者肝移植前外周血免疫细胞表型的特征。【方法】通过多色流式细胞术对6例准 备接受肝移植的肝癌患者及6例健康对照组外周血中T细胞、B细胞、单核细胞亚群、树突状细胞（DC）及NK细 胞进行免疫表型分析。【结果】与健康对照组比较，肝癌肝移植受者组患者外周血CD4 + PD-1 + T细胞、调节T细胞 （CD4 + CD25 + CD39 + ）、B细胞、浆母细胞（CD27 high CD38 high IgD - IgM - ）、经典型单核细胞（CD14 high CD16 - ）及未成熟NK 细胞（CD3 - CD56 high ）均升高，差异具有统计学意义（P

简单介绍了天津水上温泉欢乐谷屋盖的多种选型设计方案,以及排水坡度和屋面支托稳定性等关键技术。针对这种大面积单体多点支承的网架结构体系的特殊性,结合近年来的暴雪灾害天气,设计了该网架的监测方案,包括监测条件、测点布置与监测方法,并分别于2009年10月11日和2010年1月4日对网架节点竖向位移进行了监测,与MSGS软件的理论分析结果进行对比分析,验证了该结构在大雪天气条件下的安全性。同时,考虑设计正负温差、极端正负温差和上下弦杆不均匀温度场的影响,计算了不同温度作用下网架结构支座处节点的水平位移值,得到了极端正温差作用能使网架结构在支座处产生一定水平力的重要结论,并为大跨度空间网格结构的安全设计与使用提供了一定的参考。

光纤流量传感器是一种基于光信号的新型流量传感器。光纤中传输的光信号受到流量的作用,其强度、相位、波长等参数都会发生变化,通过检测光信号相关的变化可得到相应的流量大小。文章就几种类型的光纤流量传感器的工作原理及特性进行了阐述,对它们的优缺点进行分析比较,并提出了改进方案。

文章分析了用四波混频产生边带并传输基带信号的光纤无线通信（ROF）系统。该系统中心站处产生两对载波抑制边带,一对传输下行链路信号,另一对承载基带信号并在基站传输上行链路信号。通过仿真得到的系统光谱图、误码率曲线表明:加入基带信号传输后,下行信号的能量损耗不变,基带信号和上行信号却有较好的抗色散能力。

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the application value of the facial artery perforator pedicled V-Y advancement flap in the treatment of middle and lower facial tumors in the elderly population. Methods A retrospective analysis was performed on the data of 35 elderly patients who underwent extensive resection of middle and lower facial tumors and reconstruction using the facial artery perforator pedicled V-Y advancement flap from January 2017 to December 2023 in Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University. Collect their basic information, postoperative flap survival rate, incidence of postoperative complications, and patient satisfaction, and conduct retrospective analysis. Results All 35 patients' skin flaps survived, and there were 2 cases of skin flap tip bruising after surgery, with a total complication rate of 5.71%. After a follow-up period of 3 to 6 months postoperatively, there was no significant difference in the color and texture of the recipient skin flap compared to the surrounding skin. The overall patient satisfaction rate was 94.29%. Conclusion The V-Y advancement flap of the perforating branch of the facial artery has reliable blood supply, similar color and texture to the recipient area, low cost in the donor area, and high patient satisfaction. It has high clinical application value in the treatment of lower facial tumors in elderly patients. [ABSTRACT FROM AUTHOR]

Objective To establish a training system for laboratory operators in Biosafety Level 2 laboratories, aimed at enhancing the knowledge level of personnel, standardizing operational skills, and reducing laboratory accidents. Methods The Delphi method was employed to conduct two rounds of consultations with 17 experts in the field of biosafety from Beijing, Shanghai, Xinjiang, Fujian, Anhui, Chongqing, Guangzhou, and Shenzhen to determine the indicator system, while the Analytic Hierarchy Process (AHP) was used to establish the weights of the indicators. Results The response rates for the two rounds of questionnaires were 94.44% and 100.00%, respectively, with expert authority coefficients of 0.962 and 0.944. The Kendall's coefficient of concordance (W) was high (all P < 0.01). Ultimately, the training system was defined to include 5 primary indicators, 21 secondaiy indicators, and 83 tertiary indicators. Conclusion This training system is structurally complete and content-rich, demonstrating strong scientific validity and reliability, and can serve as a reference for the training and assessment of laboratory operators in Biosafety Level 2 laboratories. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Dermatovenereology is the property of Xi'an Jiaotong University Periodicals Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Pathophysiology is the property of Jinan University, School of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Surfactant Detergent & Cosmetics (2097-2806) is the property of China Surfactant Detergent & Cosmetics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To investigate and analyze the distribution of serum cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) and squamous cell carcinoma-associated antigen (SCCA) levels in healthy pregnant women during pregnancy and to assess their diagnostic value for cervical cancer in pregnancy. Methods A total of 441 healthy pregnant women and 69 patients with cervical cancer in pregnancy who attended the Obstetrics and Gynecology Hospital of Fudan University from Jan 2021 to May 2024 were selected, and 165 healthy women in the Physical Examination Center of the Obstetrics and Gynecology Hospital of Fudan University were included in the same period as the control group. The healthy pregnant women were divided into 143 in early pregnancy (T1 group), 147 in middle pregnancy (T2) and 151 in late pregnancy (T3). Serum CYFRA21-1 and SCCA values were detected and analyzed in all groups. Oneway ANOVA, independent samples t-test, Mann-Whitney U-test, Kruskal-Wallis H-test, logistic analysis, and ROC curves were used for comparative analysis. Results The CYFRA21-1 and SCCA values were 1.66 (1.19-2.17) ng/mL and 0.8 (0.6-1.0) ng/mL in the control group, 3.07 (2.11-4.14) ng/mL and 0.9 (0.7-1.3) ng/mL in the healthy pregnant women group, and were 4.33 (2.99-7.60) ng/mL and 1.8 (0.9-8.5) ng/mL in the patients with cervical cancer in pregnancy group, respectively. There was a statistically significant difference in the two serum values between every two groups (P<0.05). CYFRA21- 1 levels were 3.13 (2.46-4.05) ng/mL, 1.89 (1.50-2.53) ng/mL and 4.19 (3.48-5.43) ng/mL in the T1, T2, and T3 groups, respectively; and SCCA levels were 0.9 (0.7-1.1) ng/mL, 0.7 (0.6-1.0) ng/mL and 1.2 (0.8-1.7) ng/mL, respectively. The results of T1 and T3 groups were higher than those of the control group (P<0.05); however, there was no statistically significant difference between the results of the T2 group and those of the control group (P>0.05). The areas under the ROC curves for the diagnosis of cervical cancer in pregnancy for CYFRA21-1, SCCA, human epididymis protein 4 (HE4), anticarcinoembryonic antigen (CEA) and joint indicators were 0.684, 0.724, 0.612, 0.791 and 0.913, with sensitivities of 36%，48%，38%，57% and 73%，specificities of 96%，97%，89%，86% and 99%, respectively. The cut-off values of each indicator were 6.05 ng/mL, 2.60 ng/mL, 51.45 pg/mL and 1.75 ng/mL, respectively. Conclusion Serum CYFRA21-1 and SCCA levels were higher in pregnant women during early and late pregnancy compared with non-pregnant individuals, while they were not statistically different from non-pregnant women during mid-trimester. CYFRA21-1 and SCCA have diagnostic value for patients with cervical cancer during pregnancy. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the effects of national centralized drug volume-based procurement policy, drug negotiation and key monitoring on application of proton pump inhibitors (PPI) in hospitals, so as to provide data support for the rational application of PPI and evaluation of implementation effect on related policies. METHODS: Application data of PPI from 2018 to 2022 were extracted from the drug use database of sample hospitals of the National Pharmaceutical Information Network (including 892 hospitals, with 645 tertiary hospitals and 247 secondary hospitals). Consumption amount and proportion, consumption sum and proportion, daily defined dose system (DDDs) and daily defined dose (DDC) and other indicators were analyzed and compared. RESULTS: From 2018 to 2022, due to the influence of relevant policies, the consumption sum and DDC of PPI in sample hospitals decreased year by year. The reduction of PPI injection was greater than that of PPI oral preparation. The consumption amount structure and consumption sum structure of PPI changed significantly. The consumption amount of PPI injection and DDDs of most injection varieties decreased significantly. CONCLUSIONS: From 2018 to 2022, Consumption sum and consumption amount of PPI injection in sample hospitals decrease significantly, yet the alternative application among different clinical varieties still deserves further evaluation. [ABSTRACT FROM AUTHOR]

Objective To investigate the effectiveness of drug-coated balloons (9DCB) in treating acute coronary lesions and their impact on inflammatory response. Methods A total of 192 patients with acute myocardial infarction who underwent percutaneous coronary intervention (9PCI) within 12 hours of admission were selected. According to the PCI treatment strategy, they were divided into the DCB group (9102 patients) and the drug-eluting stent (9DES) group (990 patients). The study observed the effects of the two treatment plans on acute coronary lesions and inflammatory response. Results There were no statistically significant differences between the two groups in general baseline data, lesion vessels, DCB/DES sizes used, or pre-and post-procedure TIMI flow grades (9P＞0.05). The immediate lumen diameter and lumen gain in the DCB group were inferior to those in the DES group (9P＜0.01), and the incidence of vascular dissection in the DCB group was higher than in the DES group (9P＜0.01). At the 9-month follow-up, the late lumen loss (9LLL) in the DCB group was better than that in the DES group (9P＜0.01), and the fractional flow reserve (9FFR) was similar between the two groups. There were no statistically significant differences in the incidence of major adverse cardiac events (9MACE) and bleeding events caused by dual antiplatelet therapy between the two groups (9P＞0.05). Inflammatory markers in both groups were significantly lower than pre-procedure levels, and at follow-up, the inflammatory markers in the DCB group were significantly lower than those in the DES group (9P＜0.01). Conclusion The efficacy of DCB in treating acute coronary lesions is not inferior to that of DES. Additionally, DCB has a better inhibitory effect on the inflammatory response of local lesions, suggesting potentially better long-term outcomes. [ABSTRACT FROM AUTHOR]

In order to solve the problems of loss of moving targets due to the flight status of the unmanned aerial vehicle (UAV) itself, the interference of the environment the randomness of the target and other reasons in the process of collecting moving target image information by the UAV platform, a deep deterministic policy gradient (DDPG) algorithm UAV following method based on moving target recognition was proposed. Facing the vehicle target on the highway, the relationship among the height, posture and high-speed vehicle motion of the UAV was analyzed. the velocity adaptive model of the target detection frame rate of the mobile platform was estab lished, and the flight attitude and speed of the UAV were corrected in real time according to the motion state of the target, so that the UAV could maintain the relative position and angle with the target. Then, based on the value network of DDPG algorithm, the value of UAV taking spe- cific actions in different states was estimated; the strategy network generates the strategy of UAV taking actions in a given state, and gives UAV flight altitude and speed control parameters for target tracking, so that the UAV could automatically adjust the flight state according to the movement change of the target, and realize the adaptive tracking of the moving target. Simulation experiments show that the DDPG algorithm can provide stable flight attitude data and a reliable control basis for the UAV following task, and the UAV can track the ground moving target in a circular area with a speed range of 0~33 m/s and a radius of 120 m in real time, and can achieve continuous and stable tracking within the endurance range. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Dermatovenereology is the property of Xi'an Jiaotong University Periodicals Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To retrospectively analyze the effect of Bailing capsule on microinflammation and renal function in patients with diabetic nephropathy. Methods: From January 2021 to September 2022, the clinical data of 120 patients with diabetic nephropathy admitted to our hospital were retrospectively collected and divided into the hypoglycemic and lipid-lowering group (56 cases) and the Bailing capsule group (64 cases) according to the treatment methods. The hypoglycemic and lipid-lowering group was treated with metformin tablets and rosuvastatin calcium tablets. The bailing capsule group was treated with bailing capsules on the basis of the hypo- glycemic and lipid-lowering group. The curative effect after 3 months of treatment, glucose and lipid metabolism index, micro-inflammatory state and renal function before and after 3 months of treatment were compared between the two groups. Results: The therapeutic effect of the Bailing capsule group after 3 months was higher than that of the hypoglycemic and lipid-lowering group (P<0.05). After 3 months of treatment, level of serum fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), serum levels of creatinine (SCr), urea nitrogen (BUN) and 24 h urinary albumin (24 h) in both groups UTP) and urinary albumin excretion rate (UAER) were lower than before treatment, and the Bailing capsule group was lower than the hypoglycemic and lipid-lowering group (P<0.05). The level of serum interleukin-10 (IL-10) in the two groups was higher than that before treatment, and that in the Bailing capsule group was higher than that in the hypoglycemic and lipid-lowering group (P<0.05). Conclusion: Bailing capsule coyld effectively improve glucose and lipid metabolism, renal function and microinflammation in patients with diabetic nephropathy, with good curative effect. [ABSTRACT FROM AUTHOR]