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目的了解成都地区女性宫颈脱落细胞人乳头瘤病毒(HPV)感染状况和基因分布特征,为本地区女性HPV感染提供流行病学依据。方法采集成都地区58 650例女性宫颈脱落细胞,采用HPV基因分型方法检测23种HPV基因型的分布、年龄特征、感染模式。结果 58 650例女性中,感染HPV 12 399例,HPV阳性率为21.14%。其中高危型、低危型、高危和低危混合感染型患者分别占71.81%、12.16%、16.03%。18种高危型HPV的感染率由高到低依次为52、16、58、53、51、68、56、18、59、33、66、39、31、35、45、83、73、82,5种低危型HPV的感染率由高到低依次为81、43、42、6、11。总感染率、高危型感染率、高低混合型感染率、多重感染率的感染高峰年龄段均为<20岁和≥60岁,30~<50岁年龄段感染率最低;低危型感染率和一重感染率的高峰年龄段均为≤20岁。HPV感染模式中单一感染占72.30%,多重感染占27.70%(以二重感染为主)。<20岁和≥60岁年龄段患者以多重感染为主。结论成都地区女性HPV基因分型感染率随年龄呈U形分布;应加强对<20岁和≥60岁女性HPV感染的监测。 [ABSTRACT FROM AUTHOR]