Objective To explore the effect of sodium hyaluronate gel combined with collagen injection on improving nasolabial groove. Methods From October 2022 to October 2023, 35 cases of nasolabial fold wrinkles were treated in the Department of Burn and Plastic Surgery of the Third Affiliated Hospital of Naval Military Medical University. Fill the nasal base with hyaluronic acid combined with collagen to fill nasolabial fold wrinkles, and were followed up and photographed 1, 3, 6 and 12 months after operation. Statistical WSRS score, GAIS score, measurement of facial convexity, incidence of adverse events, patient satisfaction. Results The WSRS scores of 35 patients were (1.23±0.42), (1.51±0.57), (1.71±0.46) and (2.03±0.67) respectively at 1, 3, 6 and 12 months after injection. GAIS scores were (4.43 ±0.55), (3.77± 0.54), (3.14± 0.42) and (2.26±0.44) respectively at 1, 3, 6 and 12 months after injection. The facial convexity at 1, 3, 6 and 12 months after injection was (172.80。±1.55。), (173.91。±1.48。), (174.89。±1.53。) and (175.71。±1.76。) respectively, compared with that before injection (176.63。± 1.80。). There were 4 cases of edema (11.4%) and 1 case of induration (2.9%) after injection. The totalsatisfaction rate of patients was 85.7%(30/35). Conclusion Sodium hyaluronate gel combined with collagen injection is a safe, comfortable, effective and lasting method to improve nasolabial groove, which has high aesthetic value and is a better way to improve nasolabial fold wrinkles. [ABSTRACT FROM AUTHOR]