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BACKGROUND: Bibliometrics and visual analyses based on thematic literature are particularly important for understanding the foundation and frontiers of postmenopausal osteoporosis research. OBJECTIVE: To perform bibliometric, citation, and visualization analyses of highly cited SCI papers in postmenopausal osteoporosis research over the last 20 years. METHODS: The top 100 highly cited papers on postmenopausal osteoporosis published between 2003 and 2022 included in SCI-EXPANDED catalog of the Web of Science database were obtained for bibliometric measure and visual analysis using CiteSpace software. RESULTS AND CONCLUSION: The top 100 highly cited papers have a total of 67 377 citations in the Web of Science Core Collection, with an annual average of 49.17 citations per paper. Postmenopausal osteoporosis research primarily involves medical, engineering, biological, and multidisciplinary fields. The subcategories are dominated by endocrinology and metabolism, and medicine: internal medicine. Stable and close cooperative network relationships have been formed globally. United States, University of California System, Cummings, and Steven R are the country, research institution, and author, respectively, with the most highly-cited publications. The frontiers of postmenopausal osteoporosis research mainly include calcium and vitamin D supplementation and fracture risk, clinical studies of bisphosphonates in the treatment of postmenopausal osteoporosis, atypical femur fracture, clinical studies of new drugs and sequential treatment of postmenopausal osteoporosis, predictors of fracture risk, mid- and long-term follow-up of osteoporotic vertebral compression fractures, genetic polymorphisms and hereditary factors, formulation and updating of clinical practice guidelines for postmenopausal osteoporosis. Large cohort studies, high-quality randomized controlled trials, systematic reviews, meta-analyses, and clinical practice guidelines are the great engines that drive the development of clinical research in postmenopausal osteoporosis. We should make efforts in the above areas to improve China’s international influence in the field of osteoporosis. [ABSTRACT FROM AUTHOR]

：目的　探讨乙酰半胱氨酸雾化吸入联合阿奇霉素序贯治疗小儿肺炎支原体肺炎（MPP）的临床效果。 方法　选择 MPP患儿 215例，随机分为联合治疗组 72例、雾化吸入组 72例、序贯治疗组 71例。雾化吸入组予吸入 用乙酰半胱氨酸溶液雾化吸入治疗，序贯治疗组予盐酸阿奇霉素注射液静脉滴注、阿奇霉素干混悬剂口服序贯治 疗，联合治疗组予吸入用乙酰半胱氨酸溶液雾化吸入联合阿奇霉素序贯治疗，三组均连续治疗14天。治疗14天结 束，比较三组临床疗效；治疗前和治疗 14 天结束，比较三组临床症状或体征消失时间以及血清免疫球蛋白（IgA、 IgM、IgG）、心肌酶谱［肌酸激酶同工酶MB（CK-MB）、谷草转氨酶（AST）、乳酸脱氢酶（LDH）、心肌肌钙蛋白（cTn）］和 炎症因子［CRP、IL-6、IL-33、TNF-α、可溶性程序性死亡受体1（sPD-1）］水平；比较三组治疗14天内不良反应发生率。 结果　联合治疗组总有效率高于雾化吸入组和序贯治疗组（P均<0. 05），而雾化吸入组与序贯治疗组总有效率比较 差异无统计学意义（P>0. 05）。联合治疗组咳嗽、发热、肺部阴影、肺部啰音消失时间均显著低于雾化吸入组、序贯 治疗组（P均<0. 05），而雾化吸入组与序贯治疗组比较差异均无统计学意义（P均>0. 05）。三组治疗后血清免疫球 蛋白（IgA、IgM、IgG）、心肌酶谱（CK-MB、AST、LDH、cTn）及炎症因子（CRP、IL-6、IL-33、TNF-α、sPD-1）水平均低于治 疗前，并且联合治疗组治疗后上述指标均低于雾化吸入组和序贯治疗组（P均<0. 05），而雾化吸入组与序贯治疗组 治疗后上述指标比较差异均无统计学意义（P均>0. 05）。三组治疗期间不良反应发生率比较差异无统计学意义（P> 0. 05）。结论　乙酰半胱氨酸雾化吸入联合阿奇霉素序贯治疗小儿 MPP不仅能快速缓解临床症状或体征，还能降 低机体免疫球蛋白、减轻心肌损伤、抑制气道炎症，安全有效。 [ABSTRACT FROM AUTHOR]

Objective To investigate the difference in the efficacy of sequent teriparatide with denosumab and sequent teriparatide with zoledronic acid in the treatment of osteoporosis in patients with osteoporotic vertebral compression fracture after percutaneous vertebroplasty. Methods A retrospective selection was conducted on 60 postmenopausal osteoporosis patients who underwent percutaneous vertebroplasty at the Nanjing First Hospital from December 2020 to December 2023 and were treated with terlipide for 12 months postoperatively. According to the sequential medication situation， the patients were divided into the denosumab group and the zoledronic acid group，with 30 cases in each group. The changes of serum P1NP，serum β-CTX，lumbar spine BMD，hip BMD and the occurrence of refracture were compared between the two groups before treatment， at 6th month and at 12th month，and the differences of curative effect between the two groups were evaluated. Results The BMD growth rate of hip in the denosumab group was higher than that in the zoledronic acid group after 12 months of treatment (P<0.05). The BMD of lumbar spine and hip in the two groups at 12th month was higher than that before treatment (P<0.05). The BMD of lumbar spine in the denosumab group and the zoledronic acid group at 12th month was 8.7 % and 6.7 % higher than that before treatment， respectively. The BMD of hip in the denosumab group and the zoledronic acid group at 12th month was 6.6 % and 2.9 % higher than that before treatment，respectively. The levels of serum P1NP and serum β-CTX in the denosumab group were lower than those in the zoledronic acid group at 6th month and at 12th month (P<0.05). There was no significant difference in the incidence of refracture between the two groups during treatment (P>0.05). Conclusion In postmenopausal osteoporosis patients with OVCF，teriparatide sequent with denosumab is more effective than sequent with zoledronic acid in increasing bone mineral density in the hip and reducing bone metabolism markers. The two treatment regimens have no significant effect on the incidence of recurrent fractures. [ABSTRACT FROM AUTHOR]

This paper summarized the nursing measures for a patient with chronic obstructive pulmonary disease complicated with type II respiratory failure treated by sequential non-invasive positive pressure ventilation via nasal high-flow oxygen therapy. Nursing interventions were carried out in the following ways: non-invasive positive pressure ventilation, medication nursing, enteral nutrition support, pipeline maintenance, skin care and psychological nursing and other issues. Efforts were made to improve the respiratory failure status and various vital signs, control of carbon dioxide retention and reduce the occurrence of complications. By providing patients with a constant, adjustable, high-speed breathing gas mixture formed from air and oxygen, it was aimed to crush the gas left in the nasal cavity, oral cavity and pharynx, and significantly reduce the amount of carbon dioxide inhaled during the next inhalation. The application of sequential treatment with transnasal high-flow oxygen therapy has achieved positive therapeutic results in patients with hypoxic respiratory failure. (本文总结经鼻高流量氧疗序贯无创正压通气治疗1例慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者的护理干预措施, 主要从无创正压通气护理、用药护理、肠内营养支持、管路护理、皮肤护理及心理护理等方面进行干预, 旨在改善患者呼吸衰竭状况和各项生命体征, 控制二氧化碳潴留病情, 减少并发症的发生。通过为患者提供恒定的、可调节的高速空氧混合气体, 冲刷患者呼气末残留在鼻腔、口腔及咽部的解剖无效腔的气体, 可明显减少患者下一次吸气时吸入的二氧化碳的含量。经鼻高流量氧疗序贯治疗的应用, 对低氧性呼吸衰竭患者具有积极的治疗效果。)

Osteoporosis is a common systemic bone disease. A series of clinical final events such as fractures caused by osteoporosis are seriously affecting the national health level of our country. At present, the risk and efficacy of long-term use of anti-osteoporosis drugs are not clear, and the chronic disease management of osteoporosis is facing challenges. In recent years, many clinical studies have shown that sequential treatment of different types of drugs can effectively improve bone mineral density and reduce the risk of fracture. Sequential therapy has become the only way for the treatment of osteoporosis. However, the specific sequential scheme needs to be further studied and discussed. The purpose of this paper is to summarize the important research results of sequential treatment of osteoporosis in recent years and to provide reference for clinical work. [ABSTRACT FROM AUTHOR]

肺癌是中国及全球范围内最普遍的癌症之一, 其发病率和致死率逐年增加, 而在肺癌中, 最常见的 病理类型为非小细胞肺癌 (NSCLC)约占80%~85%。亚洲非小细胞肺癌 (NSCLC)患者中 EGFR基因的突变率约 为40%~60%, EGFR基因突变主要为外显子19的框内缺失 (45%为Ex19del)和外显子21的错义突变 (40%~45%为 21 L858R )。所以, 对于 EGFR基因突变的晚期非小细胞肺癌 (NSCLC)治疗模式的研究是目前临床上最关键的工 作。本文拟探讨化疗序贯EGFR-TKIs与单药EGFR-TKIs一线治疗EGFR基因19del和L858R突变的晚期非小细胞肺癌 (NSCLC)的临床效果, 探索上述两种治疗方案的优点及局限性, 从而指导临床用药。 [ABSTRACT FROM AUTHOR]

目的: 探究红霉素、阿奇霉素序贯治疗小儿肺炎支原体肺炎的价值。方法: 选取于2021年6月至2023年6 月本院收治的68例小儿肺炎支原体肺炎患儿, 随机分为观察组 (阿奇霉素序贯治疗)、对照组 (红霉素序贯治疗) 各 34人。结果: 相比对照组, 观察组治疗总有效率高, 临床症状改善更明显 (P < 0.05)。结论: 阿奇霉素序贯治疗小 儿肺炎支原体肺炎的临床价值更加显著。 [ABSTRACT FROM AUTHOR]

Objective·To investigate the efficacy and safety of early ultrafiltration in acute decompensated heart failure (ADHF) patients with volume overload. Methods·One hundred patients with ADHF admitted to cardiac care unit of Tongren Hospital, Shanghai Jiao Tong University School of Medicine from July 2018 to September 2019 were randomly divided into early ultrafiltration group (n=40) and diuretic group (n=60). In the early ultrafiltration group, blood ultrafiltration was performed within 3 d after admission, and diuretic sequential treatment (Torasemide 20 - 40 mg/d and Tolvaptan 7.5-30.0 mg/d) was given on day 4 to 7. The diuretic group received intensive treatment (Torasemide 20-40 mg/d and Tolvaptan 7.5-30.0 mg/d) after admission. On the 4th and 8th day of treatment, the body mass and urine volume of the two groups were compared; on the 8th day, dyspnea score, internal diameter of inferior vena cava (ICV), inferior vena cava-collapse index (IVC-CI), jugular vein pressure (JVP) and B-type natriuretic peptide (BNP) were compared between the two groups. The readmission rate and mortality of the two groups at 1-month and 3-month follow-up were compared. The heart rate, respiratory rate, blood pressure, serum sodium, serum potassium and serum creatinine levels of the two group on the 8th day of treatment were compared with those before treatment, respectively. Results·Compared with the diuretic group, weight loss and urine increase in the early ultrafiltration group on the 4th day and the 8th day showed significant difference (all P<0.05). There were significant differences in the changes of dyspnea score, IVC, IVC-CI, JVP and BNP on the 8th day of treatment between the two groups (all P<0.05). No significant differences were found in the safety indexes in the two groups, and the readmission rate and mortality rate in the two groups at 1-month and 3-month follow-up. Conclusion·Early ultrafiltration can effectively remove excess body fluids, reduce body weight, increase the sensitivity of patients to diuretics. It has no effect on blood pressure, electrolytes and renal function. [ABSTRACT FROM AUTHOR]

目的观察超声引导下经皮经肝胆囊穿刺引流术(PTGD)联合腹腔镜下胆囊切除术(LC)序贯治疗老年高危急性化脓性胆囊炎的效果。方法选取50例老年急性化脓性胆囊炎合并严重心肺功能障碍的患者,于超声引导下PTGD联合LC序贯治疗,观察患者的治疗效果,比较患者术前及术后3、7 d体温,血WBC,血生化指标ALT、AST、血浆白蛋白、总胆红素水平。ELISA法测定血清炎性因子IL-6、单向免疫扩散法测定血清C反应蛋白。结果PTGD术后3、7 d患者体温与术前比较明显降低,差异有统计学意义(P均<0.05)。术后3、7 d患者WBC、ALT、AST、血浆白蛋白、总胆红素、CRP水平与术前比较明显降低,差异有统计学意义(P均<0.05)。结论对于不能耐受急症手术的老年危重化脓性胆囊炎患者,通过PTGD+LC序贯式疗法能明显提高治疗效果。 [ABSTRACT FROM AUTHOR]

目的观察经肝动脉化疗栓塞术（TACE）联合125I放射性粒子植入序贯治疗近心旁原发性肝细胞肝癌（HCC）的临床疗效及可行性。方法选取癌灶位于近心旁的67例HCC患者,随机分为观察组35例和对照组32例;观察组行TACE联合125I放射性粒子植入序贯治疗,对照组单纯行TACE治疗。取术前及术后第1个月静脉血检测AFP、AST、ALT、ALB,术后第3个月复查MRI评价近期疗效;术后随访36个月,计算生存率。结果与术前相比较,两组术后第1个月血AFP、AST、ALT降低而ALB升高,且观察组改善程度较对照组明显,差异有统计学意义（P均<0.05）。观察组总体有效率为74.3%、疾病控制率为88.6%,显著高于对照组的28.1%、65.6%（P均<0.05）。观察组术后6、12、36个月生存率分别为88.6%、77.1%、42.9%,明显高于对照组的50.0%、34.4%、18.8%（P均<0.05）。术后第3天观察组中心肌酶谱出现轻度改变3例,5例出现放射性胃肠反应改变,均对症处理后好转。结论 TACE联合125I放射性粒子植入序贯治疗近心旁HCC安全、有效。 [ABSTRACT FROM AUTHOR]

OBJECTIVE:To probe into the effects of budesonide aerosol inhalation combined with azithromycin sequential therapy in treatment of children with mycoplasma pneumonia. METHODS:124 children with mycoplasma pneumonia admitted from Feb. 2015 to Aug.2016 were selected to be divided into two groups via the random number table, with 62 cases in each.The control group were treated with azithromycin sequential therapy, while the observation group additionally received budesonide aerosol inhalation. The clinical effects, changes of clinical symptoms and signs, and adverse drug reactions of two groups were observed and compred. RESULTS: After treatment, the total effective rate of observation group was 95.16%( 59/62 ), and control group was 85.48%(53/62), the difference was statistically significant (P<0.05).The disappearance time of cough and hoarseness of observation group were significantly lower than those of control group; indicators of absolute neutrophil count and C-reactive protein in two groups improved significantly, and the observation group was better than that of control group, with statistically significant difference ( P <0.05 ).During treatment, the incidence of adverse drug reactions of observation group was 6.45%( 4/62 ), significantly lower than that of control group [ 16.13%( 10/62 ) ], with statistical significance ( P<0.05 ). CONCLUSIONS:The incidence of mycoplasma pneumonia in children are relatively high, the use of azithromycin sequential therapy combined with budesonide inhalation can significantly improve the symptoms with few adverse drug reactions. [ABSTRACT FROM AUTHOR]