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Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Osteoarthritis is the most common joint disease in elderly populations. Promising therapy that can control or even reverse the course of disease effectively remains unrevealed. Clinical trials focusing on applying adipose-derived stem cells for treating knee osteoarthritis have been conducted in the last few years, while the safety and viability remain unknown. OBJECTIVE: To summarize the completed and processing clinical trials in which adipose-derived stem cells are applied in treating knee osteoarthritis and to demonstrate the safety and efficiency. METHODS: PubMed, MEDLINE, Web of Science and Clinicaltrails.gov were searched for studies applying adipose-derived stem cells in the treatment of knee osteoarthritis up to December 2017. Inclusion criteria included randomized controlled trials, cohort studies and case series providing detailed study design, clinical data and follow-up results. Outcome measures included level of evidence, study design, inclusion criteria for patients, protocol for adipose-derived stem cells, clinical outcomes and serious adverse events. RESULTS AND CONCLUSION: Nine completed clinical trials (2 controlled studies, 2 dose-effect studies, 5 case series) were included. All studies reported a significant improvement after applying adipose-derived stem cells in pain management and joint function recovery and no serious adverse events were observed. These findings confirmed the effectiveness and safety of adipose-derived stem cells in the treatment of knee osteoarthritis, while these studies provided low-level evidence. [ABSTRACT FROM AUTHOR]