Search

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective　To study the effect of Huqian pill on the modulation of bone mineral density and the level of BMP-２ in ovariectomized rats．Methods　Forty ６-month-old female SD rats were randomly divided into ４ groups： model group， estrogen group， Huqian pill group， and sham operation group．After the establishment of the model， rats in Huqian pill group received concentrated liquid gavage once a day．Rats in estrogen group received nylestriol suspension once a week．Rats in model group and sham operation group received distilled water once a day．After a 12-week treatment， bone mineral density （BMD） and BMP-２ were determined．Results　BMD in Huqian pill group and estrogen group was improved comparing to that in model group， and the difference was significant （P ＜０．０５）．The level of BMP-２ was also improved in the bone tissue， and the difference was significant （P ＜０．０５）．Conclusion　Huqian pill has an obvious treatment effect on ovariectomized rats．It can improve the level of BMP-２ in tissue， resulting in the inhibition of bone resorption and stimulation of bone formation． [ABSTRACT FROM AUTHOR]