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目的 探讨以问题为导向的教学法（problem-based learning，PBL）联合循证医学教学法（evidencebasedmedicine，EBM）在高级卒中中心进行住院医师规范化培训中的应用效果。 方法 连续入组2019-2021年在神经内科高级卒中中心学习的60名规培住院医师，随机分为观察组和对照组各30名，观察组采用PBL+EBM教学法，对照组采用授课式教学法（lecture-based learning，LBL），以3个月为培训周期，培训后对2组进行理论及操作实践考核，比较教学效果，并对培训人员进行教学满意度的调查。 结果 观察组的理论测试成绩（83.66±5.12分 vs. 75.53±7.36分，P＜0.001）、临床操作实践测试成绩合格率（93.3% vs. 73.3%，P =0.040）以及教学满意度（76.6% vs. 40.0%，P =0.001）均高于对照组。 结论 PBL联合EBM教学法可提高高级卒中中心规范化培训的教学效果。 Abstract: Objective To explore the teaching results of problem-based learning (PBL) combined with evidence-based medicine (EBM) teaching method in standardized training for residents at advanced stroke center. Methods Sixty residents who studied at advanced stroke center from 2019 to 2021 were enrolled in this study. They were randomly divided into observation group and control group. The PBL combined with EBM teaching method was used in observation group, the lecture-based learning (LBL) was used in the control group. The training period was 3 months. The teaching results were evaluated by theory and skill exams and satisfaction survey of the two groups. Results The scores of theory (83.66±5.12 vs. 75.53±7.36, P

目的 评估普罗布考与阿托伐他汀钙联合治疗急性脑梗死（acute cerebral infarction，ACI）的疗效，以提供ACI的治疗参考方案。 方法 回顾性收集2018年1月—2023年9月在重庆市急救医疗中心就诊，发病24 h内住院的ACI患者资料。纳入患者需满足：接受了阿托伐他汀钙（20 mg，每晚1次）单药或联用普罗布考（0.5 mg，每日2次）调节血脂治疗，且治疗周期为3个月以上。根据是否联用普罗布考分为联合治疗组和对照组，比较两组治疗后神经功能（使用NIHSS评估）、神经功能结局（使用mRS评估）、生活能力（使用Barthel指数评估）以及血脂水平的差异。 结果 研究共入组102例患者，其中联合治疗组56例，对照组46例。两组的基线资料差异无统计学意义。治疗后14 d两组的NIHSS评分和血脂水平、治疗3个月后的血脂水平均较本组治疗前显著改善（均P

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