Search

Copyright of China Mechanical Engineering is the property of Editorial Board of China Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of zinc gluconate combined with racecadotril on plasma inflammatory factors, myocardial enzymes and immune function in children with rotavirus enteritis. Methods: A total of 97 children with rotavirus enteritis who were admitted to our hospital from February 2017 to July 2019 were selected, they were randomly divided into control group (n=48) and study group (n=49) according to the random number table method. On the basis of routine treatment, the control group was treated with racecadotril granules. The study group was treated with zinc gluconate oral solution on the basis of the control group. The efficacy and plasma inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), serum myocardial enzyme indexes [lactate dehydrogenase (LDH), creatine phosphokinase-isoenzyme-MB (CK-MB) and creatine phosphokinase (CK)] and immune function indexes (CD4+, CD8+, CD4+/CD8+) changes of two groups were compared. Results: The total clinical effective rate of the study group at 7 d after treatment was 91.84% (45/49), which was higher than 75.00% (36/48) of the control group (P<0.05). The levels of plasma IL-6 and TNF-α of the two groups decreased at 7 days after treatment, and the levels of the study group were lower than those of the control group (P<0.05). The levels of LDH, CK and CK-MB of the two groups decreased at 7 days after treatment, and the levels of the study group were lower than those of the control group (P<0.05). 7 days after treatment, CD8+ of the two groups decreased at 7 days after treatment, and that of the study group was lower than that of the control group (P<0.05). CD4+, CD4+/CD8+ were increased, and that of the study group were higher than that of the control group (P<0.05). No serious adverse reactions were found in the two groups (P>0.05). Conclusion: Zinc gluconate combined with racecadotril in the treatment of rotavirus enteritis children has a significant effect, which can improve the inflammatory factors and myocardial enzyme indexes, and enhance the immune function of children, and no serious adverse reactions have been observed. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)