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Exhibitions are an integral part of academic library services, contributing significantly to the library's educational and cultural functions. By integrating exhibitions into their services, academic libraries increase the utilization and appreciation of the collections, promote cultural and intellectual communication, and foster students' lifelong learning and diverse competencies, thus enhancing the role as a center for learning, culture, and community engagement. However, current research and services indicated issues such as an overemphasis on international exhibition studies over in-depth exploration of domestic exhibition services, a focus on the subject of exhibition over the demands of library users, an inclination towards the cultural instruction function of exhibitions over the development of their diversified functions, and a preference for experiences and practices over systematic planning and design. Investigating the problem of systematic construction of academic library exhibition services from the perspective of student demands can effectively address these deficiencies, bringing academic and practical value. With a questionnaire survey, data were collected on university students' demands for library exhibition services from various colleges and grades at an applied undergraduate university in Guangdong Province. The questionnaire design covered six aspects of student demands: exhibition purposes, theme preferences, information acquisition channels, interaction needs, supporting services, and expectations for collaborating units. The survey results indicated that students primarily visit exhibitions to appreciate art, enjoy leisure activities, and acquire knowledge. Students have a wide range of theme preferences, including art creation exhibitions, film exhibitions, and historical and cultural exhibitions. Social media platforms like WeChat and Weibo are the most convenient channels for students to obtain exhibition information. Students prefer to interact with exhibitions through social media and short video platforms. They expect the library to provide supporting services such as on-site electronic interactive displays, on-site explanation or consultation services, and online virtual exhibitions. Additionally, students expect the library to collaborate with various units, including subordinate colleges, administrative departments, student organizations and external institutions. Finally, based on the survey results, strategies for the systematic construction of academic library exhibition services are proposed: reshaping the exhibition value system, reconstructing the systematic design of exhibitions which includes the diversification of exhibition categories, the design of exhibition scale and frequency and the design of the exhibition implementation process, optimizing the exhibition interaction mechanism by creating impressive online exhibitions, providing immersive interactive experiences, establishing effective feedback and evaluation mechanisms, and promoting the implementation of exhibition policies to support the high-quality, connotative, and sustainable development of the exhibition system. [ABSTRACT FROM AUTHOR]

Copyright of China Mechanical Engineering is the property of Editorial Board of China Mechanical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of zinc gluconate combined with racecadotril on plasma inflammatory factors, myocardial enzymes and immune function in children with rotavirus enteritis. Methods: A total of 97 children with rotavirus enteritis who were admitted to our hospital from February 2017 to July 2019 were selected, they were randomly divided into control group (n=48) and study group (n=49) according to the random number table method. On the basis of routine treatment, the control group was treated with racecadotril granules. The study group was treated with zinc gluconate oral solution on the basis of the control group. The efficacy and plasma inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), serum myocardial enzyme indexes [lactate dehydrogenase (LDH), creatine phosphokinase-isoenzyme-MB (CK-MB) and creatine phosphokinase (CK)] and immune function indexes (CD4+, CD8+, CD4+/CD8+) changes of two groups were compared. Results: The total clinical effective rate of the study group at 7 d after treatment was 91.84% (45/49), which was higher than 75.00% (36/48) of the control group (P<0.05). The levels of plasma IL-6 and TNF-α of the two groups decreased at 7 days after treatment, and the levels of the study group were lower than those of the control group (P<0.05). The levels of LDH, CK and CK-MB of the two groups decreased at 7 days after treatment, and the levels of the study group were lower than those of the control group (P<0.05). 7 days after treatment, CD8+ of the two groups decreased at 7 days after treatment, and that of the study group was lower than that of the control group (P<0.05). CD4+, CD4+/CD8+ were increased, and that of the study group were higher than that of the control group (P<0.05). No serious adverse reactions were found in the two groups (P>0.05). Conclusion: Zinc gluconate combined with racecadotril in the treatment of rotavirus enteritis children has a significant effect, which can improve the inflammatory factors and myocardial enzyme indexes, and enhance the immune function of children, and no serious adverse reactions have been observed. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the inhibitory effect of polydatin on the proliferation and invasion in lung cancer A549 cells and its mechanism. Methods The lung cancer A549 cells were treated with different concentrations of polydatin (0, 10, 20, 50, 100 and 200 mg/L) for 24, 48 and 72 hours. The proliferation of A549 cells was measured by tetrazolium nitrogen salt (MTS) assay to determine the concentration of subsequent experiments (10 mg/L and 20 mg/L for 48 h). With different concentrations of polydatin (0, 10 and 20 mg/L) for 48 hours, the invasion of A549 cells was measured by Transwell assay. The expression levels of matrix metalloprotinase (MMP)-2/9, integrin β4, Toll-like receptor (TLR3), cluster of differentiation (CD44) and phosphorylation of serine/threonine kinase (p-AKT) were measured by Western blotting and real-time PCR assay. The content of transforming growth factor (TGF)-β and tumor necrosis factor (TNF)-α in culture medium were measured by ELISA assay. The activity of nuclear factor (NF) - κB was measured by report gene assay. Results In the concentration ranges of 0, 10, 20, 50, 100 and 200 mg/L polydatin for 24, 48 and 72 h, the cell proliferation was decreased, and 10 mg/L and 20 mg/L of polydatin treatment for 48 h were used for following experiments. After treatment with polydatin for 48 h, the invasion was decreased, the contents of TGF-β and TNF-α were decreased, and the expression levels of MMP-2 / 9, integrin β4, TLR3, CD44, p-AKT and the activity of NF - κB were also decreased (P＜0.05). Conclusion Polydatin can inhibit the proliferation and invasion of lung cancer A549 cells by regulating the expression of tumor reated gene and the activity of AKT/NF-κB signal pathway. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Hydrogeological condition is one of the most important factors controlling the migration,dispersion,distribution and accumulation of coalbed methane (CBM) in coal reservoir.In this paper,the water produced from CBM wells in Gujiao mining area was monitored in terms of concentrations,water quality and salinity.Then,combined with the local gas content and the distribution characteristics of groundwater,the geological controlling mechanisms on gas distribution characteristics in different units were discussed.Results show that the main ions of produced water were Na+,HCO3- and the type was NaHCO3.The total dissolved solids (TDS) of produced water were relatively lower,which ranged from 632 to 2 512 mg/L,belonging to freshwater-saline water.The research area were divided into runoff zone,weak runoff zone and stagnant zone,and the stagnant zone according to discounted water level and TDS.The stagnant zone had the highest gas content,while the gas content in the weak runoff zone was relatively lower.The enrichment of Gujiao mining area was controlled by structure and hydrogeological conditions.Now two hydraulic patterns were identified:The monocline-hydraulic sealing in the central of Malan was the richest area and the horst-hydraulic sealing in Dongqu was the richer area. [ABSTRACT FROM AUTHOR]

Objective To explore the mechanism of vessel endothelial dysfunction in rats under intermittent hypoxia (IH). Methods The respiratory simulation system was used to simulate IH. Sixty C57BL/6J rats (male) were randomized into control group and IH group. The rats of IH group were exposed to IH 8 hours per day for 6 weeks. The serum levels of hypoxia inducible factor (HIF)-1a and stromal cell derived factor (SDF)-1a were assessed by ELISA. The serum levels of reactive oxygen species (ROS) were detected in two groups. The serum expression of miR-199a-5p was detected by realtime fluorescent quantitative PCR in two groups. The dual luciferase report system and point mutation test were used to verify target gene for HIF-1a. Results The serum levels of HIF-1a and SDF-1a were significantly higher in IH group than those of control group (μg/L: 1.60±0.02 vs. 1.19±0.02, 1 823.00±8.97 vs. 1 444.00±17.90, P＜0.01). The serum level of ROS was significantly higher in IH group than that of control group (U/mL: 487.66±35.73 vs. 211.57±23.82, P＜0.01). The serum level of miR-199a-5p expression was significantly lower in IH group compared to that of control group (1.31±0.07 vs. 3.47± 0.17, P＜0.01). The result of dual luciferase reporter gene detection confirmed that target gene of miR-199a-5p was HIF- 1a. Conclusion The serum level of miR-199a-5p is decreased first due to IH, and then its target gene (HIF-1a) is increased. HIF-1a can induce the increased level of SDF-1a, and its receptor (CXCR-4 ) is also increased. Finally, HIF- 1a can increase the serum level of ROS, resulting in the endothelial dysfunction. [ABSTRACT FROM AUTHOR]

Objective To investigate protective effects of tripterygium wilfordiipoly glucosides (TWP)on the toll like receptor 4(TLR4)-mediated immune and inflammatory signaling pathway on type 2 diabetes fatty liver disease and elucidate the possible involved mechanisms. Methods Seventy-five healthy male Sprague Dawley rats, aged 4-5 weeks and weighed (161±9) g, were divided to normal control group (NC,n=15) and high-fat diet group(n=60) by random number table method. Type 2 diabetes model was induced with 8-week high-fat diet followed by low-dose streptozocin(STZ) injection(30 mg/kg). The diabetic rats were randomly assigned to four groups: diabetes mellitus group (DM,n=11), low-dose TWP (1 mg·kg-1·d-1, DM+TL,n=10), medium-dose TWP(3 mg·kg-1·d-1,DM+TM,n=13), and high-dose TWP (6 mg·kg-1·d-1,DM+ TH,n=11). Treatment was given by gavage once daily for 8 weeks.We analyzed the liver histopathological change, and the gene and protein expression of TLR4 and nuclear factor-κB(NF-κB) by real time PCR and Western blotting, and the levels of serum downstream inflammatory factors interleukin 1β(IL-1β) and tumor necrosis factor α(TNF-α) by ELISA.The significance of the data obtained was evaluated using analysis of variance (ANOVA). Results (1)Compared to the normal control group,diabetic rats were found to have obvious steatohepatitis and inflammatory cell infiltration. TWP-treated diabetic rats showed reduced hepatic inflammation in different levels. (2)TLR4 and NF-κB mRNA and protein expression in the hepatic tissue in the DM group were significantly increased, compared with those in the NC group(7.02±1.45 vs 1.05±0.18, 8.91±1.59 vs 1.04±0.25, 2.31±0.17 vs 1, 2.84±0.38 vs 1, respectively,t=7.157-16.540, allP<0.05). The expression of TLR4 and NF-κB mRNA and protein showed different significantly between groups (F= 12.992-60.578,P<0.05 all above), and was decreased in TWP treatment groups in a dose-dependent manner (t=2.264-7.223, all P<0.05).(3)Serum IL-1β and TNF-α in different groups showed different significantly (F=57.717,42.992,P<0.05 all above).Serum IL-1β and TNF-α in DM group were significantly increased, compared with those in the NC group(t=14.669,10.327,P<0.05 all above) and were decreased in TM and TH group (t=3.663-4.924,P<0.05 all above). Conclusions TWP treatment may delay the progression of diabetic non-alcohol fatty liver disease via inhibition of TLR4/NF-κB signaling cascade pathway, and its downstream inflammatory effectors. [ABSTRACT FROM AUTHOR]

Objective To explore the repair possibilities of endothelial progenitor cells (EPCs）in peripheral blood in patients with different extents of obstructive sleep apnea (OSA) through measuring the levels of pro-angiogenic factors and different subgroups EPCs in peripheral blood in patients with OSA. Methods Ninety adult patients with OSA, 30 healthy controls with matched age and gender were enrolled for this study. The subjects performed Polysomnography, were divided into four group based on Apnea Hypopnea Index (AHI). The serum levels of HIF-1α, SDF-1α and VEGF were assessed by ELISA. Mononuclear cells were isolated from peripheral blood with density gradient centrifugation, and flow cytometry was used to detect levels of CD133+ KDR+ EPC, CD133+ CD34+ EPC, CD34+ KDR+ EPC and ALDHlo CD34+ KDR+ EPC based on AL-DH activity, and CD133, CD34, PE-KDR related cell surface markers. Results The levels of CD133+ KDR+ EPC, CD133+ CD34+ EPC, CD34+ KDR+ EPC were higher in OSA groups than those of control group, both of which were higher in severe OSA group than those of in mild and moderate OSA groups. The levels of ALDHlo CD34+ KDR+ EPC were higher in mild and moderate OSA groups than that of the control groups, and the levels of ALDHlo CD34+ KDR+ EPC were significantly lower in severe OSA group than those of control, mild and moderate OSA groups. Serum levels of HIF-1α. VEGF were significantly higher in OSA groups compared to those in control groups, both of which were higher in severe OSA group than those of mild and moderate OSA groups. Serum levels of SDF-1α were significantly lower in severe OSA groups than those of mild, moderate OSA and control groups (P < 0.05). Conclusion The mobilization and recruitment of different subtypes of EPCs are obviously increased in patients with OSA, but ALDHlo CD34+ KDR+ EPC with vascular repair capacity keeps to invariability, even decreases in patients with severe OSA, which results in endothelial damage, and increases the risk of cardiovascular disease. [ABSTRACT FROM AUTHOR]