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In order to mitigate mode collapse when generative adversarial networks (GANs) synthesis images, this paper proposed maximizing middle modes and minor modes in generative adversarial networks (MMMGANs). First of all, MMMGANs defined the mode of the generated images with the identical label as the middle mode and the minor mode. The middle mode and the minor mode separately represented the collection of similar modes and the possible mode changes after learning the middle modes. Secondly, based on the above definition, this paper proposed maximizing middle modes and minor modes loss. Finally, on the premise that the distribution of generated images was possibly close to the real image, MMMGANs improved more than 90% of evaluation metrics and then enhanced diversity of generated images. Extensive experimental results show that the proposed maximizing middle modes and minor modes loss effectively alleviates mode collapse in two or more different types of tasks. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between single nucleotide polymorphism (SNP) of pharmacokinetic genes and postoperative disease-free survival in patients with esophageal squamous cell carcinoma, and to evaluate the prognosis of patients undergoing surgery. Methods Seventy-seven patients with esophageal squamous cell carcinoma were selected in the study. Seven SNPs-ATP binding cassette subfamily B member 1 (ABCB1) rs1045642, rs2032582, rs3213619, ATP binding cassette subfamily G member 2 (ABCG2) rs2231137, rs2231142, ATP binding cassette subfamily C member 1 (ABCC1) rs246221 and ATP binding cassette subfamily C member 2 (ABCC2) rs3740066 were sequenced, and the relationship between genetic variation and disease-free survival was evaluated by Cox regression model. Semi-Bayesian shrinkage method was applied to correct for multiple comparison and small sample size issues. Results With the dominant genetic model, the minor allele of ABCC2 rs3740066 was significantly associated with shorter disease-free survival [crude hazard ratio (cHR) 95%CI= 4.623 (1.111-19.241), P=0.035, adjusted hazard ratio (aHR) 95% CI= 4.290 (1.010-18.215), P= 0.048]. Conclusion The SNP rs3740066 of pharmacokinetic gene ABCC2 is associated with postoperative disease-free survival in patients with esophageal squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

The effects of different concentration nutrient solution on the growth characteristics, yield and quality of lettuce (Lactuca sativa L. Lvju) were studied for providing appropriate nutrient concentrations for the planting of lettuce under plant factory conditions. In this experiment, different concentration nutrient solution of EC 1.0,1.5,2.0,2.5,3.0 dS/m (CK,T1,T2,T3, T4) were designed and the physiological indicators, yield, and quality of lettuce were measured at 14,21, and 28 d after planting. The results show that when planting 14,21, and 28 d, different concentration nutrient solution had a significant impact on the shoot fresh weight, shoot dry weight, root fresh weight, number of leaves, leaf thickness, plant stretching, stem, and chlorophyll content. The soluble sugar content had a little difference between 21 and 28 days of transplanting. Based on the above measurement indicators, when planting 28 d, the concentration of nutrient solution is better in the growth status of lettuce at T2 and T3, the optimal yield and quality, and it is a relatively suitable nutritional solution irrigation concentration. [ABSTRACT FROM AUTHOR]

Laboratory plays an important role in improving the students' practical ability. In order to cultivate students' skills, which is the main goal of vocational education, laboratory cannot be ignored. As a platform of knowledge transformation and technological innovation, laboratory provides convenience for the majority of teachers and students. In order to improve the standardization and rationality of laboratory construction and its application, By summarizing the construction management experience, interviewing the first-line teachers for the management and use of laboratory, combining the reality of vocational education needs and modern information environment, the paper impacted on the laboratory construction, analyzed laboratory important role in vocational education. Furthermore, this paper put forward the principle of laboratory construction, laboratory management system and evaluation system to guide the cultivation of experiment personnel and system construction. [ABSTRACT FROM AUTHOR]

Objective To investigate the toxic effects and mechanisms of silica nanoparticles on myocardial mitochondrial. Methods The Balb/c mice were intratracheally instilled with silica nanoparticles (40 nm) at three doses of 7, 21 and 35 mg/kg every three days for a total of 5 times. Control group was given the same volume of normal saline. The transmission electron microscope was used to observe the ultrastructure of myocardial mitochondria. By measuring the concentration of ATP，the effect of silica nanoparticles on the function of myocardial mitochondria was evaluated. Through the detection of the ability of anti O2-·in the myocardial tissue, the antioxidant capacity of mitochondria in cardiac muscle was evaluated. The expression levels of cytochrome coxidase subunit 1 (COX1) and succinate dehydrogenase subunit a (SDHA) were detected by Western blot assay. Results The results showed that silica nanoparticles at high dose can damage the structure of myocardial mitochondrial, which induced swelling of mitochondria，mitochondrial cristae disorder disappeared and even mitochondrial fusion. Silica nanoparticles (21 and 35 mg/kg) can induced the decrease in functions of mitochondria. Silica nanoparticles (7 and 21 mg/kg) can enhance the myocardial antioxidant capacity. But high dose of silica nanoparticles can induce the decrease in the myocardial antioxidant capacity. Silica nanoparticles (21 mg/kg) induced mitochondrial biosynthesis, but high dose of silica nanoparticles (35 mg/kg) inhibited mitochondrial biosynthesis. Conclusion Silica nanoparticles (35 mg/kg) can induce the production of O2-· and decrease the antioxidant capacity of mitochondria, which leads to the damage of the function and structure of the mitochondria and inhibits the mitochondria biosynthesis. [ABSTRACT FROM AUTHOR]