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目的 探索颈动脉支架置入术（carotid artery stenting，CAS）后发生需药物干预低血流动力学（hemodynamic depression，HD）状态的危险因素。 方法 回顾性分析潍坊市中医院脑病科2017年2月—2021年12月因颈动脉狭窄行择期单侧CAS治疗患者的临床资料，记录患者CAS后24 h内的生命体征。根据CAS后24 h内是否发生HD状态[定义为收缩压＜90 mmHg（1 mmHg=133.3 Pa）或心率＜50 次/分且需要血管活性药物干预]分为HD组和非HD组。采用多因素logistic回归分析CAS后发生需药物干预HD的独立危险因素。 结果 研究共纳入130例CAS患者，其中有42例（32.3%）发生了需药物干预的HD。单因素分析示，HD组的糖尿病病史（28.57% vs. 48.86%，P=0.034）、空腹血糖[（5.46±1.71）mmol/L vs. （6.69±2.06）mmol/L，P＜0.001]低于非HD组，责任血管最狭窄处距颈动脉分叉≤10 mm的比例（71.43% vs. 47.73%，P=0.021）、责任血管高回声斑块发生率（7.14% vs. 3.41%，P=0.043）和使用开环支架的比例（85.71% vs. 56.82%，P=0.024）高于非HD组。多因素logistic回归分析显示，责任血管最狭窄处距颈动脉分叉≤10 mm（OR 3.10，95%CI 1.23～8.11，P=0.028）和高回声斑块（OR 3.28，95%CI 1.45～9.36，P=0.021）是CAS后发生需药物干预HD的独立危险因素，而糖尿病病史（OR 0.25，95%CI 0.07～0.91，P=0.031）和高空腹血糖水平（OR 0.18，95%CI 0.02～0.51，P=0.024）是CAS后发生需药物干预HD的独立保护因素。 结论 责任血管高回声斑块和最狭窄处距颈动脉分叉≤10 mm是CAS后发生需药物干预HD的独立危险因素。 Objective To determine the predictors of hemodynamic depression (HD) requiring vasoactive agent following carotid artery stenting (CAS). Methods Patients who underwent unilateral CAS in Department of Neurology, Weifang Hospital of Traditional Chinese Medicine between February 2017 and December 2021 were enrolled in this retrospective study. Patient vital sign records within 24 hours post-CAS were analyzed. The HD was defined as sustained systolic blood pressure

多智能体协同在众多领域逐渐得到应用，但是还有很多仍未解决的问题。为此，研究了基于无模型自适应动态规划（MFADP）的未知异构多智能体系统同步控制问题，其中领航者智能体和追随者智能体动态模型均是未知的。首先为每一个追随者智能体设计观测器来估计领航者智能体的信息，包括领航者智能体状态以及领航者智能体系统动态矩阵。然后利用追随者智能体动态模型信息和观测器动态模型信息构建增广系统，运用贝尔曼最优性原理求得最优控制器以及对应的代数黎卡提方程。在追随者智能体系统动态模型信息未知的情况下，引出了MFADP算法。最后使用双质量-弹簧系统来验证所提算法的有效性。

Objective To explore the application of ALA photodynamic fluorescence combined with dermatoscopy in the diagnosis of facial cancerization and precancerous lesions. Methods From March 2022 to March 2024, a total of 52 patients with actinic keratosis, BOWEN's disease, squamous cell carcinoma and basal cell carcinoma were enrolled at the dermatology clinic of the First Affiliated Hospital of Henan University of Science and Technology. Each patient was examined by naked eye and ALA photodynamic fluorescence, and the difference in area was compared between these two methods. The ALA photodynamic fluorescence area was divided into 8 equal sections, followed by examination with a dermatoscope to determine whether there were cancerization and precancerous lesions. The lesion area and severity were scored. Results The ALA photodynamic fluorescence area was larger than that observed by the naked eye (all P<0.001). Dermatoscopic examination of the ALA photodynamic fluorescence imaging area revealed precancerous features of various areas and severity, with cancerous area and severity scores of 4.55±1.21, 5.45±2.42, 6.64±2.84, and 5.27±1.95, respectively. Conclusions ALA-photodynamic fluorescence combined with dermatoscopy can find cancerization and precancerous lesions that can't be detected by naked eyes, providing a new method for early screening and early diagnosis of skin cancerization and precancerous lesions. [ABSTRACT FROM AUTHOR]

This paper used the theoretical tool of knowledge bases, constructed the index system from five dimensions of production, consumption, labor market, foreign trade and innovation to explore the spatial evolution of economic resilience and the impacts of different knowledge bases on regional economic resilience in the Pearl River Delta. The results are as follows: ①Industrial knowledge bases are differentiated into five types: analytical knowledge base, symbolic knowledge base, analytical-synthetic knowledge base, synthetic-analytical-symbolic knowledge base, and synthetic-symbolic-analytical knowledge base. ②From 2005 to 2019, the region‐ al economic resilience level of central cities increased noticeably, while that of the eastern and western cities decreased. As a whole, the spatial structure of economic resilience changes from the "double core" of the central and eastern regions to the "single core" of the central regions. ③ The specialization of analytical knowledge base and proportional equalization of knowledge bas‐ es significantly improve regional economic resilience, while the specialization of symbolic knowledge base and synthetic-symbolic-analytical knowledge base go against the improvement of economic resilience. ④Research and development resources have significant positive effects on the improvement of economic resilience, while economic scale has negative effect. Through the innovative source of knowledge production, understanding and identifying the differences in economic resilience performance of cities with different innovative characteristics can provide a new framework and ideas for the differentiated strategy of enhancing regional resilience and path selection of sustainable development. [ABSTRACT FROM AUTHOR]

Copyright of New Media Research is the property of New Media Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To understand the disease knowledge of elderly patients with chronic obstructive pulmonary disease（COPD） in grassroots areas of Chongqing, and to provide evidence for the prevention and treatment of COPD. Methods From November 2021 to May 2022, a total of 612 elderly patients with COPD were randomly selected from the grassroots areas of Chongqing for a cross-sectional study. The self-designed socio-demographic questionnaire and COPD knowledge questionnaire were used to investigate. Logistic regression model was used to analyze the influencing factors of disease knowledge in elderly patients with COPD. Results A total of 612 questionnaires were distributed, of which 578 valid were recovered, with an effective recovery rate of 94. 4%. The average score of disease knowledge of 578 elderly COPD patients was（4. 73±2. 57） points, with a full score of 13 points. Among them, the highest scoring rate of a single item was 81. 3%, and the scoring rate of five items was less than 20. 0%. The results of logistics regression analysis showed that region（P＜0. 001） and income（P＜0. 001） were the influencing factors of disease knowledge in elderly COPD patients. Conclusion The disease knowledge of elderly patients with COPD in the grassroots areas of Chongqing is not ideal, and the region and income are the influencing factors. The team of general practitioners and various levels of medical and health management departments should strengthen health education for patients and reduce the incidence of serious diseases caused by cognitive impairment. [ABSTRACT FROM AUTHOR]

Objective To observe the clinical efficacy and safety of guselkumab injection in the treatment of moderate to severe plaque psoriasis. Methods Twenty three patients with moder. ate to severe plaque psoriasis were treated with subcutaneous injection of guselkumab at a dose of 100 mg at weeks 0 and 4, followed by once every 8 weeks. The psoriasis lesion area and severity index (PASI) were evaluated at weeks 4 and 12, and adverse reactions were recorded. Results All 23 patients received treatment at least 3 times (0, 4, 12 weeks). At week 12： 23 patients (100%) achieved PASI 75 or above, including PASI 90 in 19 patients (82.61%) and PASI 100 in 10 patients (43.48%) . No serious adverse reactions were observed. Conclusions Guselkumab is safe and effective for moderate to severe plaque psoriasis, and can rapidly improve skin lesions. It provides a new treatment option for patients with moderate to severe plaque psoriasis. [ABSTRACT FROM AUTHOR]

In view of current situation of insufficient research on the theme of environmental carrying capacity of karst caves, Sanjiao Cave in Jiuxiang, Yiliang, Yunnan is taken as an example to obtain karst cave point cloud data through terrestrial laser scanning and establishes a fine three-dimensional model. According to the requirements of tourism cave planning and designing, the initial model is cut and extracted by using the height of safe water level in study area, and the lower model of safe water level is removed to obtain the tourism cave space model and accurately calculate the size of tourists' sightseeing space. On this basis, considering various cave environmental influencing factors such as CO2 concentration, heat, light and river, the traditional ecological environment capacity method is improved, and the mathematical model of karst cave environmental carrying capacity based on three-dimensional model is established to calculate the maximum environmental carrying capacity of undeveloped caves, so as to better guide the development and design of karst caves. Compared with the traditional calculation method, it is found that heat is the most limiting factor of environmental carrying capacity of cave tourism. At the same time, according to the calculation results, the maximum difference in instantaneous bearing capacity is 19 146 people, and the maximum difference in daily bearing capacity is 123 189 people. The calculation results are more scientific and reasonable, more in line with the actual situation. [ABSTRACT FROM AUTHOR]

Copyright of Ecological Science is the property of Ecological Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Cancer Research on Prevention & Treatment is the property of Cancer Research on Prevention & Treatment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shenyang Pharmaceutical University is the property of Shenyang Pharmaceutical University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Metabolomics is a technology which understands the changes of all endogenous metabolites in the organism at a certain time through comprehensive and quantitative detection of endogenous small molecular compounds in the biological system, screening out significant biomarkers, and providing new ideas for early prediction, diagnosis and exploration of pathogenesis of diseases. Missed abortion is a common gynecological disease, and its pathogenesis has not been fully elucidated. At present, metabonomics technology has been applied to the study of missed abortion, and biomarkers that may be associated with missed abortion have been found, involving a variety of pathways such as tricarboxylic acid cycle, oxidative stress and signal transduction, making a breakthrough. This article briefly introduces the metabonomics technology and its application in the study of missed abortion, and to further discusses the explore of differential metabolites in serum and changes in related metabolic pathways on missed abortion. [ABSTRACT FROM AUTHOR]

Copyright of Piezoelectrics & Acoustooptics is the property of Piezoelectric & Acoustooptic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Leucine-rich glioma inactivated 1 (LGI1); antibody-associated encephalitis is an autoimmune disease with complex and diverse clinical manifestations and is prone to misdiagnosis. In this article, one case of LGI1 antibody-associated encephalitis was reported. This patient presented with loss of consciousness and limb twitches as the first symptoms, which occured twice within a year. No obvious abnormal signal was found by MRI. Autoimmune encephalitis antibody test showed that both serum and cerebrospinal fluid samples were positive for LGI1 antibody, which confirmed the diagnosis. Relevant symptoms were significantly improved after glucocorticoid use and immunotherapy. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Stroke is the property of Chinese Journal of Stroke Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tropical Geography is the property of Tropical Geography Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的：对口腔科护理中应用感染优化护理管理的护理效果进行讨论。方法：选择本院在2020年8 月至 2021 年4月收治的84例口腔科患者，随机分成对照组和研究组，每组42例。对照组采用常规护理，研究组在常规护理 基础上，同时采用感染优化护理管理，对两组患者症状康复时间以及护理满意度进行对比。结果：研究组血常规、体 温恢复、痰量减少以及住院时间，均显著低于对照组，差异具有统计学意义（P < 0.05）；研究组护理满意度显著高 于对照组（P < 0.05）。结论：在口腔科护理中应用感染优化护理管理可以显著提高护理效果。通过对研究组和对照 组的比较，发现研究组在血常规、体温恢复、痰量减少以及住院时间等方面表现出明显的优势，这些差异具有统计学 意义。同时，研究组的护理满意度也明显高于对照组。对口腔科护理中的感染管理问题具有积极的影响。因此，建议 在口腔科护理中普遍应用感染优化护理管理，以提高患者的护理效果和满意度。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Currently, there is less focus on "knowledge heterogeneity" among different innovation subjects in inter-city innovation network research. Knowledge bases theory has gradually become a new entry point from the perspective of "knowledge heterogeneity" in regional theory and practice research. In this study, we explore the structural characteristics and proximity mechanism of inter-city innovation networks formed by heterogeneous knowledge-based industries, using the Yangtze River Delta Urban Agglomeration as a case study. We theorize knowledge creation logic as having two dimensions, that is, knowledge creation dynamics and economic performance, and develop a framework with a quantitative method to identify the typology of industrial knowledge bases. We use modified gravity models to construct inter-city innovation networks of heterogeneous industries, divided into different knowledge bases in the Yangtze River Delta urban agglomeration from 2005 to 2019. To clarify how these inter-city innovation networks evolve and what effects proximity has on evolution, we conduct social network analysis and implement the Quadratic Assignment Procedure (QAP). The results show the following: (1) Industrial knowledge bases are divided into five types, namely, analytical, symbolic, analytical-synthetic, synthetic-analytical-symbolic, and synthetic-symbolic-analytical. Therefore, innovation networks are also defined as these types. (2) The analytical network outlines a dual-core structure while other network structures are multi-core; the analytical, analytical-synthetic, and synthetic-analytical-symbolic networks are evidently oriented by core cities with administrative or economic functions; the central cities of the subgroups are closely connected, while the core cities of symbolic and synthetic-symbolic-analytical networks vary greatly, and weak connections appear within these subgroups; for the analytical, symbolic, analytical-synthetic, and synthetic knowledge base-dominated network structures, their evolution trends are increasingly compact, "loose-compact-loose", "compact-loose-compact", and relatively stable, respectively. (3) Inter-city innovation links are facilitated by geographical proximity, except for analytical networks. Cognitive proximity and technological proximity have a significant positive impact on innovation links. Institutional proximity contributes to the formation of analytical and analytical-synthetic networks. The interaction between geographical and technological proximity has a significant positive effect on innovation networks. In the analytical, symbolic, and analytical-integrated networks, the interaction of geographical proximity and cognitive proximity induces cities to contact each other. Theoretically, through China's practical application scenarios, this study quantitatively identifies the combination form of industry knowledge base for the first time and further deepens the connotation of knowledge bases theory. Simultaneously, it also addresses the deficiency of attention to the "knowledge heterogeneity" of the innovation subject in research on inter-city innovation networks. Practically, it provides a new perspective for optimizing the allocation of innovation resources for different types of knowledge-based subjects in the Yangtze River Delta urban agglomeration, improving the efficiency of inter-city knowledge circulation, building a differentiated regional innovation system, and formulating innovation governance strategies. [ABSTRACT FROM AUTHOR]

[Objectives J The study aimed to study the control effect of botanical pesticide azadirachtin against Ostrinia furnacalis in sorghum. [ Methods J The activity of azadirachtin against 0. furnacalis was determined by diet incorporation method in the laboratory, the control efficacy was investigated in the three sorghum fields, and the safety evaluation on three sorghum varieties was determined by pot method. [ Results J Under indoor condition, the LC50 value of 2nd ins tar larvae was 6.44 mg· L- 1 , and the activity was relative high. The efficacy on plant protection and insect control effects in three provinces were ranged from 80.07% to 89.26% and 73.51 % to 87.31 %,and those were significantly better than control pesticides. The growth inhibition rate of 0.3% azadirachtin emulsifiable concentrate at the dosage of 18 g • hm - 2 was significantly higher than 4.5, 9 g • hm - 2 for three sorghum varieties, one plant of all three sorghum varieties showed leaf edge chlorosis,and one plant of 'Chiza No.16' showed leaf edge chlorosis of 0.3% azadirachtin emulsifiable concentrate at the dosage of 9 g • hm - 2 after 14 d of spraying, the growth of three sorghum varieties was normal and safe for sorghum. [ Conclusions] Azadirachtin had good toxicity activity and control effect against O.furnacalis,and it was safe for sorghum. [ABSTRACT FROM AUTHOR]

To clarify the feasibility and safety of using the combination of famoxadone and metalaxylM against Plasmopara viticola in grape, the indoor co-toxicity test, field control efficacy test and residue behavior test were carried out. The results showed that the type of joint effect was synergistic on P. viticola when the ratio of famoxadone and metalaxyl-M was 1 : 1, with the EC50 value was 2.52 mg/L and the co-toxicity coefficient was 154.53. The best field control efficacy of 30% famoxadone + metalaxyl-M SC (at the mass ratio of 1 : 1) against P. viticola was 83.9% after 3 times of application at the dosage of 120-200 mg a.i./kg with interval of 7 d. The control effect of 30% famoxadone + metalaxyl-M SC at the dosage of 200 mg a.i./kg was significantly better than that of 68.75% famoxadone + mancozeb WG at the dosage of 687.5 mg a.i./kg, and the control effect of 30% famoxadone + metalaxyl-M SC at the dosage of 120 and 150 mg a.i./kg was significantly better than 68% metalaxyl-M + mancozeb WG at the dosage of 1 360 mg a.i./kg. At the spiking levels of 0.1, 0.5, 1.0 and 5.0 mg/kg, the average recoveries of famoxadone and metalaxyl-M in grape were 91%-107% and 92%-107%, respectively, with RSD less than 5.7%. The dissipation of famoxadone and metalaxylM in grape fitted to the first order kinetics and the half-lives were 8.9-12.8 d and 7.4-10.0 d, respectively, indicating that they were easily dissipated pesticides. The results suggested that the formulation of 30% famoxadone + metalaxyl-M SC (at the mass ratio of 1 : 1) could be an effective fungicide for controlling P. viticola, with the characteristics of high efficiency, low residual, easily degraded, and safe for use, and have certain future developmental value. [ABSTRACT FROM AUTHOR]

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Fuzhou University is the property of Journal of Fuzhou University, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Henan Agricultural Sciences is the property of Editorial Board of Journal of Henan Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective]Using crude old tea leaves as the main medium to cultivate white ginseng fungus fruiting bodies, and to compare and analyze whether its main nutrients have superiority. [Method] The content of amino acid composition, main nutrient elements, protein, polysaccharide, etc. of white ginseng fungus cultivated with tea as the main material, artificially cultivated white ginseng fungus purchased in the market and wild white ginseng fungus were determined and the differences were analyzed and compared. [Result]The medium with tea as the main material is suitable for the growth of white ginseng fungus. Compared with the artificially planted and wild ones purchased in the market, the fruit bodies of the white ginseng fungus cultivated with tea as the main material have the highest content of zinc, potassium, and phosphorus in the amino acids, polysaccharides and essential nutrients for the human body. [Conclusion] It is feasible to grow white ginseng fungus on the cultivation material prepared with crude tea leaves as the main material, and it can cultivate high-quality nutrient-rich white ginseng fungus fruiting bodies. [ABSTRACT FROM AUTHOR]

This paper proposed a novel Manhattan distance based weighted t-SNE(Mwt-SNE) algorithm on the basis of improved distance in stochastic neighbor embedding(SNE). Firstly, it calculated samples Manhattan distances rather than Euclidean distance from high dimensional space for their less affections of dimension. Next, it divided these Manhattan distances into three groups with K-means clustering algorithm and implemented weighting processing separately with tabular parameter optimization method. Then it calculated similarity conditional probabilities with weighted Manhattan distances according to values category distribution. The aim of weighted Manhattan distances was to enlarge the data distinction, promote dimension reduction and enhance class ification significance. Finally, it established an Mwt-SNE algorithm based on-line fault diagnosis model and the corresponding control limit with KDE. The experimental results on TE chemical process show that the proposed Mwt-SNE algorithm reduces FAR(false alarm rate) and MAR( missing alarm rate) as well as improves stability and accuracy. [ABSTRACT FROM AUTHOR]