Search

Objective To share the data analysis of bone trabecular score (TBS) combined with bone mineral density (BMD) in our hospital, and to explore the feasibility of TBS combined with BMD in the diagnosis and treatment of osteoporosis and the prediction of fracture risk. Methods Clinical data of patients who were examined with GE Lunar dual-energy X-ray absorptiometry in our hospital from January 17, 2022 to August 22, 2022 were collected and analyzed retrospectively. The proportion of men under 50 years old and premenopausal women with different bone mass and the data trends of BMD and TBS were observed. The result of age, BMI, BMD, T-value and TBS and other risk factors were compared between the fragility fracture group and the non-fracture group of men over 50 years old and postmenopausal women. Logistic regression was used to analyze the diagnostic performance of BMD and TBS. ROC curve was used to analyze the risk prediction of osteoporotic fractures. Results The normal bone mass of males under 50 years old accounted for 97.06%, among which the risk of fracture accounted for 8. 82% and the high risk of fracture accounted for 8. 82%. The normal bone mass of premenopausal females accounted for 96. 26%, among which the risk of fracture accounted for 8. 50% and the high risk of fracture accounted for 2. 38%. There were 66 fragility fractures and 641 non-fracture cases in men over 50 years old, among which age, BMI, BMD, T-value, and TBS were statistically different between the two groups (P<0.01). There were 283 fragility fractures and 1794 non-fractures in postmenopausal women. There were significant differences in age, BMD, T-value and TBS between the two groups (P<0.01), but no significant differences in BMI between the two groups (P=0.12). Both BMD and TBS were independent predictors of fragility fractures. Combination of BMD and TBS had the largest AUC (0.748) in predicting fracture risk. Conclusion Patients with normal bone mass also have a certain risk of fracture. Age, BMD, T-value, and TBS play a role. Both BMD and TBS are independent predictors of fragility fractures. TBS brings additional diagnostic information in fracture risk assessment, thereby improving diagnostic and predictive. performance. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between osteoporosis (OP) and coronary heart disease ( CHD) in males using meta-analysis method Methods International and domestic documentary databases, including Pubmed, Cochrane, Embase, CNKI, Wanfang Data, CQVIP, and CBM, were searched. The retrieval time was from the founding of databases to June 2020. The screened reviews and literature were evaluated according to inclusion and exclusion criteria. The quality of data was assessed according to the Newcastle-Ottawa scale (NOS) and analyzed with a Review Manager 5. 3 software . Results A total of 11 papers were included. A total of 1 962 patients, 603 cases of osteoporosis, and 1 359 cases of non-osteoporosis ( osteopenia and normal ) were involved. Meta-analysis showed that the incidence of CHD in males was significantly higher in osteoporosis group than that in non-osteoporosis group (OR= 1. 43, 95% CI 1. 14-L 79, PO. 05), while in elderly males the incidence of CHD was much higher (OR= L 86, 95%C/L 12-3.08, P<0. 05). In the subgroup analysis stratified by osteopenia, there was no statistical significance of occurrence of CHD between osteopenia and normal group in middle-aged and elderly males (middle-aged males: OR= L 25, 95% CJ 0. 66 - 2. 36, P> 0. 05; elderly males : OR= L 11, 95% CI 0. 35-3. 53, P> 0. 05, respectively). Conclusion The incidence of CHD in elderly males is remarkably correlated with osteoporosis, while it is uncorrelated with osteoporosis in middle-aged males. The incidence of CHD is uncorrelated with osteopenia in middle-aged and elderly males. [ABSTRACT FROM AUTHOR]