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Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Guangxi Normal University - Natural Science Edition is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Territorial spatial ecological restoration zoning is an important basis for implementing differentiated protection and restoration strategies and an important premise for promoting the integrated protection and restoration of mountains, rivers, forests, fields, lakes, and grasses and regional coordinated governance. In the current research on territorial spatial ecological restoration zoning, less attention is paid to human demand for ecosystem services and territorial spatial ecological restoration zoning from the perspective of the supply and demand of ecosystem services. As a result, zoning is unable to solve the contradiction between human and land relations, which has a certain impact on the implementation of subsequent restoration projects. Therefore, from the perspective of ecosystem service supply and demand, this study considers the Guangdong-Hong Kong-Macao Greater Bay Area as the research area, scientifically delimiting the territorial space ecological restoration zones of the Guangdong-Hong Kong-Macao Greater Bay Area and proposes differentiated protection and restoration strategies for each zone. The results show that the spatial distribution of the comprehensive supply and demand of ecosystem services in the Guangdong-Hong Kong-Macao Greater Bay Area has a strong spatial heterogeneity. The comprehensive supply capacity mainly presented a spatial distribution pattern of high in four weeks and low in the middle, and the comprehensive demand presented a spatial distribution pattern of high in the middle and gradually decreasing from the ring to the periphery. There are many towns/streets with a spatial mismatch of supply and demand of ecosystem services (low supply and high demand; high supply and low demand), accounting for approximately 85% of the total area. There are relatively few towns/streets with spatial matching (high supply and high demand; low supply and low demand), accounting for approximately 15% of the total area. However, in space, there is a trend that the internal low-supply and high-demand areas gradually transition to the external high-supply and low-demand areas in a semicircle. According to the matching of supply and demand of ecosystem services, the Guangdong-Hong Kong-Macao Greater Bay Area was divided into four zones, and a differentiated protection and restoration strategy was proposed for each zone. In general, the key ecological conservation areas (61%) focus on nature conservation and pay attention to the maintenance of regional ecological integrity and biodiversity; the comprehensive ecological improvement zone (13%) is mainly composed of auxiliary restoration and ecological reconstruction, focusing on strengthening the construction and restoration of the suburban ecological buffer zone; the key ecological restoration areas (24%) mainly focus on auxiliary restoration and ecological remodeling to improve the ecological resilience of the area, while ecological prevention and control areas (2%) focus on nature conservation, maintaining the current ecological situation and ecological supply capacity, and preventing ecological environment degradation. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of preoperative ultrasound-guided quadratus lumborum block (QLB) combined with general anesthesia on serum stress response and pain related indexes in patients with renal transplantation. Methods: 82 patients undergoing renal transplantation in our hospital from September 2019 to August 2021 were selected as the observation objects. According to the random number table method, they were divided into group A and group B, 41 cases respectively. Group A was given general anesthesia, and group B was given preoperative ultrasound-guided QLB combined general anesthesia. The resting visual pain simulation (VAS) score, the dosage of sufentanil in patient-controlled intravenous analgesia, the number of effective compressions were compared between the two groups, the changes of serum stress response and pain related indexes were compared between the two groups, and the incidence of adverse reactions were compared between the two groups. Results: The resting VAS scores at 6 h, 12 h, 24 h and 48 h after operation in group B were lower than those in group A(P<0.05). The dosage of sufentanil in patient-controlled intravenous analgesia in group B was less than that in group A, and the number of effective compressions was less than that in group A (P<0.05). Blood glucose (Glu) and cortisol (Cor) in group B after extubation and 24 h after operation were lower than those in group A (P<0.05). Substance P (SP), prostaglandin E2 (PGE2) and serotonin (5-HT) increased 24 h after operation in the two groups, but group B was lower than group A (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P<0.05). Conclusion: Preoperative ultrasound-guided QLB combined with general anesthesia for patients with renal transplantation can effectively reduce pain and stress response, reduce the dosage of sufentanil in patient-controlled intravenous analgesia and the number of effective compressions, and do not increase the incidence of adverse reactions. [ABSTRACT FROM AUTHOR]

Copyright of Geography & Geographic Information Science is the property of Geography & Geo-Information Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Petroleum Geology & Recovery Efficiency is the property of Petroleum Geology & Recovery Efficiency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore regulatory mechanisms of autophagy in colorectal cancer cells under hypoxia. Methods:Colorectal cells were exposed to normoxia and hypoxia（1% O2）, respectively. Western blot analysis was used to detect the expressions of Silencing Information Regulator 1（SIRT1） and autophagy-related biomarkers. Lentivirus infection was used to obtained colorectal cells with stable SIRT1 overexpression or knockdown. Transmission electron microscope（TEM） was exploited to detect intracellular autophagosomes. After tumor cells were infected with adenovirus containing m RFP-GFP dual-labelled LC3, autophagy flux were detected under laser scanning confocal microscopy. Results: Western blots revealed that the expression of SIRT1 was decreased with the extension of hypoxic exposure time in HCT116 and SW480 cells. Besides, autophagy specific substrate p62 was declined and the transition of LC3-I/II was enhanced. Compared with control group, SIRT1-overexpressed SW480 cells exhibited increased expression of p62 and decreased transition of LC3-I/II. Conversely, in SIRT1-knockdowned HCT116 cells, the expression of p62 was decreased while the transition of LC3-I/II was further increased. The results from TEM observation indicated that the overexpression of SIRT1 decreased the number of autolysosomes while increased the number of autophagosomes. Moreover, confocal results revealed that in SIRT1-overexpressed cells, the quenching of green fluorescence was decreased and the fusion of autophagosomes and lysosomes was blocked, which suggested that SIRT1 inhibited the formation of autolysosomes and blocked the autophagy flux. Conclusion: Hypoxia promoted autophagy in colorectal cancer cells through inhibiting the expression of SIRT1. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of the overexpression of vascular cell adhesion molecule-1 on the apoptosis of ovarian carcinoma cells. Methods: The lentiviral vector with full length VCAM-1 gene(GV358-VCAM1+) was constructed and transfected into human ovarian carcinoma cell line, IGROV1. The tumor cells with VCAM-1 stable overexpression were selected by puromycin. The transfection rate was determined via the observation of green fluorescence under an inverted fluorescence microscope.The levels of VCAM-1 protein and m RNA were identified by western blot and RT-PCR analysis, respectively. The cell apoptosis was analyzed by flow cytometry assay. Meanwhile, the expression level of apoptosis related proteins(Bcl-2, Bax, Casepase-3 and Cleaved Casepase-3), STAT3 and p-STAT3 protein, were detected by western blot analysis. Results: The transfection rate of GV358-VCAM1+in IGROV1 cells was more than 85%. These cells had stable VCAM-1 expression not only at the protein but also m RNA level. Tumor cells with VCAM-1 overexpression had significantly higher apoptosis than those with empty vector control group(P=0.0149). Moreover,compared with the empty vector control group, there were significantly higher expression of Bax, Casepase-3 and Cleaved Casepase-3(P0.01), and lower expression of Bcl-2 and p-STAT3 in VCAM-1 overexpression group(P0.01). However, the expression level of STAT3 was not significantly changed. Conclusion: VCAM-1 could induce the cell apoptosis of ovarian carcinoma through down-regulation of STAT3 phosphorylation. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Ecology / Yingyong Shengtai Xuebao is the property of Chinese Journal of Applied Ecology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A RIL population was used in this study，which derived from a cross between a temperate maize germplasrm inbred line B31-1 and a tropical maize germplasm inbred lines Huangzao4. A genetic linkage map was constructed comprising of 153 polymorphic markers. Among the 153 polymorphic markers，82 markers showed the significant segregation distortion ( P < 0. 0 5 ) ，favoring either the marker alleles of female parent B31-1 (62. 50 % ) or male parent Huangzao4 (37. 50 % ) . Segregation distortion marker distribution along the present molecular maps of maize was far from uniform，with clusters of tightly linked loci and single marker. Nine egregation distortion regions were detected on 10 chromosomes，indicating that possible causes for segregation deviation of molecular markers are gametic selection [ABSTRACT FROM AUTHOR]

Copyright of Journal of Earth Sciences & Environment is the property of Journal of Earth Sciences & Environment and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)