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Copyright of Journal of Hainan Medical University is the property of Journal of Hainan Medical College Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective · To explore the effect of endoplasmic reticulum stress (ERS) on neutrophil elastase (NE) induced mucin 5AC (MUC5AC) production in human airway epithelial cells. Methods · HBE16 airway epithelial cells were cultured and pretreated with reactive oxygen species (ROS) inhibitor N-acetylcysteine (NAC) or ERS inhibitor 4-phenylbutyrate (4-PBA), or transfected with small interfering RNA (siRNA) against inositolrequiring kinase 1α (IRE-1α) or X-box binding protein 1 (XBP-1), respectively before incubation with NE. NE group and blank control group were also set up. ROS production was assayeddetection kit; of glucose-regulated protein 78 (GRP78), phosphorylated protein kinase R-like endoplasmic reticulum kinase (pPERK), activating transcription factor 6 (ATF6), phosphorylated IRE-1α (pIRE-1α), and XBP-1 protein was detected Western blotting; spliced XBP-1 (XBP-1s) mRNA was measuredreal-time PCR; levels of MUC5AC protein in culture supernatant and cytoplasm were assayedELISA and immunofluorescence. Results · There was an obvious increase of ROS production with strong elevation of GRP78, ATF6, pPERK, and pIRE-1α protein in NE group cells after 24 h, compared with blank control group (P<0.05). The protein and mRNA of XBP-1s, and MUC5AC production also increased obviously (P<0.05). NAC and 4-PBA reduced ERS-related protein and MUC5AC production and secretion (P<0.05). Further studies showed that MUC5AC secretion was also bluntedIRE-1α siRNA or XBP-1 siRNA, accompanied with decreased of XBP-1s mRNA and protein (P<0.05). Conclusion · NE induces ERSproducing ROS, and increases MUC5AC protein production and secretion; IRE-1α/XBP-1 play a certain role in this process. [ABSTRACT FROM AUTHOR]

Objective To compare the effects of different lung rehabilitation training method on the pulmonary function and motor function in the patients with chronic obstructive pulmonary disease（COPD）. Methods One hundred and twenty patients with COPD in the respiration department of the First Affiliated Hospital of Hainan Medical College from June 2016 to June 2017 were divided into the group A，B，C and D by adopting the dynamic randomization method，30 cases in each group. The patients in the group A conducted the respiration function exercise of lip girdle-abdominal respiration and blowing balloon； the patients in the group B conducted the respiration function exercise of lip girdle-abdominal respiration，blowing balloon and respiratory exercise training；the patients in the group C conducted the respiration function exercise of lip girdle-abdominal respiration，blowing balloon，respiratory exercise training and breathing apparatus training；the patients in the group D conducted the respiration function exercise and exercise training of lip girdle-abdominal respiration，blowing balloon，respiratory exercise training and breathing apparatus training and sports training. The differences in the lung function [vital capacity（VC），forced expiratory volume in one second（FEV1），dyspnea index and athletic ability（6 min walking distance）] on 15 d，in 3，6 months after training finish were compared among 4 groups. Results Among 120 cases，13 cases were lost to follow up，in which the group A had 3 cases（2 cases were transferred to another hospital and 1 case was converted to ICU due to the disease aggravation），the group B had 2 cases（1 case was unwilling to participate in this study due to appear dyspnea during training process and 1 case felt fear due to been affected by this case），the group C had 3 cases（1 case of converting to the cardiology department，1 case of converting to endocrinology department and 1 case of aggravation）and the group D had 5 cases（4 cases considered that there were many training items every day，which spent longer time and got bored with training，thus gave up this study, 1 case of death）. VC and EFV on 15 d and in 3 months after training finish in the group D were significantly higher than those in the group A，B and C，the differences were statistically significant（P<0.05）. VC and FEV1 in 6 months after training finish had no statistical difference among 4 groups（P>0.05）. The dyspnea symptom on 15 d and in 3 months after training finish in 4 groups was improved，while the improvement degree in the group D was most obvious，the differences were statistically significant（P<0.05）. The dyspnea score in 6 months after training finish had no statistically significant among 4 groups（P>0.05）. The 6 min walking distance on 15 d and in 3，6 months after training finish in 4 groups was improved，while the improvement in the group D was most obvious，the differences all were statistically significant（P<0.05）. Conclusion In the lung rehabilitation training methods，the method of respiratory function exercise combined with sports training can significantly improve the pulmonary function and athletic function in the patients with COPD. [ABSTRACT FROM AUTHOR]

探寻一种适宜的关于临床医学专业学位研究生综合能力的评价方法。通过建立多因素考评体系,采用改进的层次分析法给出各因素的相对权重,评价研究生各项能力及综合得分。结果显示,改进的层次分析法评价模型可合理地评价学生的综合能力,同时为客观分析学生各项能力水平提供了依据。 [ABSTRACT FROM AUTHOR]

Objective To systematically assess the application value of vitamin D supplements in the treatment of chronic obstructive pulmonary disease (COPD) to provide evidence-based reference for clinical treatment. Methods The Medline, EM Base, PubMed, Cochrane library, CNKI, VIP database and Wan Fang databases were retrieved by entering the key words. The included randomized controlled trails (RCTs) were performed the literature quality assessment and analyzed by adopting the Rev Man 5.2 software. Results Eleven randomized controlled trials (RCTs) were included, including 1 357 patients. The meta analysis results demonstrated that FEV1% in the observation group was significantly increased compared with the control group, the merge effect size mean difference (MD) of FEV1% (95% CI) was 9.78[7.30, 12.26] with statistical difference (Z=7.73, P<0.01); FEV1/FVC was also increased compared with the control group, the merge effect size MD (95% CI) was 0.09 [1.63, 18.55] with statistical difference (Z=2.34, P=0.02); the CAT scores in the observation group was significantly decreased compared with the control group, the merge effect size MD (95% CI) of CAT score was-5.16 [-5.81, -4.52] with statistical difference (Z=15.78, P<0.00001); the sputum amount in the observation group was decreased compared with the control group,the merge effect size MD (95%) of sputum amount was-6.60 [-7.27, -5.93] with statistical difference (Z=19.39, P<0.01; the serum 25 (OH) D level in the observation group was significantly increased compared with the control group, its merge effect size MD (95% CI) was 13.87 [11.84, 15.90] with statistical difference (Z=13.37, P<0.01). Conclusion Supplementing vitamin D can better improve the pulmonary function and health status, reduces the clinical symptoms and increases the level of serum 25 (OH) D. But due to the limitation of included RCT quality and design methodology, this conclusion needs the large samples and high quality RCT to be further verified. [ABSTRACT FROM AUTHOR]

Objective To observe the effect and security of Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in the adjuvant therapy of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty patients with AECOPD in the Second Affiliated Hospital of Chongqing Medical University from October to Decem-ber 2015 were selected as the research subjects and randomly divided into the conventional treatment group (32 cases) and the Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration group (experimental group, 28 cases). The effect and safety of the Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in treating AECOPD were analyzed. The clinical curative effect and occurrence rate of adverse reactions were compared between the two groups. The efficacy and safety of Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in treating this disease were analyzed. Results The hospitalization time and disappearance time of clinical symptoms and signs in the experimental group were shorter than those in the conventional treatment group, moreover the treatment total effective rate was 96.43%(27/28),which was higher than 78.13%(25/32) in the conventional treatment group;in the comparison of the sputum character on 1,2 3 d after treatment in the two groups, the sputum expectoration volume in the experimental group was increased compared with the conventional treatment group, sputum dry mass/wet mass and viscosity were decreased compared with the con-ventional treatment group, the differences were statistically significant(P<0.05);PaCO2 and PaO2 on 3,7 d after treatment in the experimental group were significantly improved compared with the conventional treatment group, the difference was statistically significant(P<0.05);the two groups had no adverse reactions occurrence during the treatment process. Conclusion The Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration as an adjuvant therapy of AECOPD has definite effect, safety and reliability. [ABSTRACT FROM AUTHOR]

Objective To compare the effects of noninvasive ventilation combined with different timing for giving the oxygen atomizing inhalation in the treatment of the patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) complicating type II respiratory failure. Methods Totally 60 patients with AECOPD complicating type Ⅱ respiratory failure admitted to the respiration department of the Second Affiliated Hospital of Chongqing Medical University from January to December 2015 were randomly divided into the observation group and control group,30 cases in each group. The observation group was given the oxygen atomizing inhalation combined with noninvasive ventilation at the same time,while the control group was given oxygen atomizing inhalation in the interval of noninvasive ventilation. The clinical efficacy and improvement of relevant indicators were observed in two groups. Results The total effective rate,p H value,arterial oxygen partial pressure,arterial carbon dioxide partial pressure,heart rate,respiratory rate,forced expiratory volume in one second(FEV1) and 6 min walking test in the observation group were 93.3%(28/30),7.40 ±0.06,(82.93 ±12.36)mm Hg,(62.00 ±6.92)mm Hg,(92.50 ±5.40)beats/min,(16.00±3.00)times/min,(3.20±0.50)V/L and(260.00±30.00)m,which were significantly better than 56.7%(17/30),7.38±0.14,(79.75±12.76)mm Hg,(65.03±8.90)mm Hg,(95.60±7.70)beats/min,(20.00±4.00)times/min,(2.90±0.50)V/L and(240.00±25.00)min the control group,the differences were statistically significant(P0.05). Conclusion Noninvasive ventilation combine with drug atomizing inhalation has a significant effect for treating AECOPD complicating type Ⅱ respiratory failure. [ABSTRACT FROM AUTHOR]

气道黏液高分泌是慢性阻塞性肺疾病的重要临床病理特征, 由于黏液过度分泌加重气道狭窄, 导致患者病情恶化, 甚至引起死亡。高度糖基化的高相对分子质量黏蛋白5AC（MUC5AC）是气道黏液的主要成分。在MUC5AC基因中含有2个核转录因子-κB（NF-κB）结合位点, 各种炎症因子能引起IκB激酶β（IKKβ）依赖的P65核转运, 使NF-κB移入核内并活化, 导致转录因子激活, 启动子活化, 促进MUC5AC基因转录增多、蛋白表达增强, 出现气道黏液高分泌[1-2]。由于NF-κB信号通路可被多种机制进行严格调控, 而其中重要的调节机制即为细胞内广泛存在的去泛素化酶（DUBs）对关键信号分子的泛素化调控。本文就DUBs对NF-κB通路的调控机制作一简要综述。 [ABSTRACT FROM AUTHOR]