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Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The incidence of endometriosis is nearly 15% among women of childbearing age with the pathogenesis been a research focus. The classic theory may encounter plentiful challenges, because it can′t account for the occurrence of ectopic lesions located in special areas distant from pelvic, while stem cell theory tries to demonstrate the pathogenesis of various kinds of ectopic lesions with "monism" point of view. Adult stem cells involved in endometriosis lesions may originate from the endometrium, bone marrow, ovary and other sources. Various kinds of molecules, such as estrogen, chemokines, epidermal growth factor, platelet -derived growth factor and other factors involved in differentiation of adult stem cell. The change of microRNA levels and epigenetic may be related to regulate the differentiation of mesenchyme stem cells into endometrial-like cells. Abnormal colonization of stem cells may change the uterine receptivity, leading to infertility, miscarriage and other adverse reproductive outcomes. Among different types of endometriosis formed, the gene expression of stem cells of peritoneal and deep infiltrating was similar, which is different from that of eutopic endometrial stem cells. With the deepening of research, stem cells are commonly used in the field of obstetrics and gynecology and have promising prospects in the treatment of premature ovarian failure, Asherman syndrome, endometriosis related infertility and targeted drug development [ABSTRACT FROM AUTHOR]

Leiomyomas are a common benign disease of the uterus which may cause an impaired impact on menstruation and fertility of reproductive-age women, while myomectomy may be the best therapeutic option. However, the risk of uterine rupture after myomectomy is one of the most serious obstetric complications that threaten the safety of mother and fetus. With the development of endoscopy，more cases about uterine rupture after myomectomy have been reported, however, there is yet no consensus about the risk factors. It′s necessary to review the literature related to uterine rupture after previous myomectomy in an attempt to summarize the potential risk factors to standardize the myomectomy technique. Surgeons are requested to be more prudent in the process of operation, including limited use of electrosurgery, not breaching the endometrial cavity and multilayered closure of myometrium. Besides, appropriate myomectomy-to-conception interval and the way of delivery also play important roles. [ABSTRACT FROM AUTHOR]