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Objective: To investigate the clinical value of transvaginal ultrasonography and hysteroscopy in the diagnosis of en­dometrial lesions, to provide a theoretical basis for the clinical diagnosis of endometrial lesions. Methods: A total of 158 cases of suspected endometrial lesions, who were treated in Beijing First Flospital of Integrated Chinese and Western Medicine from March 2011 to March 2014, were selected and were detected by transvaginal sonography and hysteroscopy respectively. The diagnostic value of the two meth­ods was compared with the results of pathological diagnosis as the gold standard. Results: In the results of pathological examination, 143 patients were diagnosed as endometrial lesions, including 23 cases of endometrial hyperplasia (16.08%), 31 cases of endometrial polyps (21.68%), 24 cases of uterine submucosal myoma(16.78%), 19 cases of endometrial carcinoma(13.29%), 46 cases of chronic nonspecific endometritis(32.17%). The accuracy rate(94.41%) of hysteroscopy in the diagnosis of endometrial lesions was higher than that(81.12%) of transvaginal ultrasound, and the difference was significant (P<0.05); there were no statistical differences in the accuracy rate of the di­agnosis of submucosal myoma of uterus and endometrial carcinoma between transvaginal ultrasonography and hysteroscopy(P>0.05), and the accuracy rate of transvaginal ultrasound in endometrial hyperplasia, endometrial polyps and chronic nonspecific endometritis was lower than that of hysteroscopy, and the difference was statistically significant (P<0.05). The specificity of transvaginal ultrasonography in the diagnosis of endometrial lesions was lower than that of hysteroscopy (P<0.05), but there were no significant differences in sensitivity and AUC between the two methods (P>0.05). Conclusion: Transvaginal ultrasonography is a simple and effective method in diagnosis of endometrial diseases, and Flysteroscopy has higher accuracy and higher specificity in diagnosis of endometrial diseases. [ABSTRACT FROM AUTHOR]

Objective: To investigate the diagnostic value of preoperative serum thyroid stimulating hormone (TSH) level combined with Doppler ultrasonography for differentiated thyroid carcinoma (DTC). Methods: 528 patients with thyroid nodules who were treated in Beijing First Hospital of Integrated Chinese and Western Medicine from January 2015 to June 2017 were selected as the subjects. 268 patients with DTC who were diagnosed by pathologically were recorded as the observation group, another 260 patients with benign thyroid nodules were recorded as the control group. The ultrasonic indexes, level of TSH in the two groups were detected and compared. The relationship between serum TSH level, lymph node metastasis and tumor diameter in the observation group was analyzed. and the diagnostic value of preoperative serum TSH combined with Doppler ultrasound in DTC was observed. Results: The number of lesions was single, the size of the lesion was small nodules, and the rate of sand like calcificationin the observation group were significantly higher than those of the control group, the differences were statistically significant (P<0.05). The proportion of patients with TSH level ranged from 2.20 to 4.20 μIU/mL and > 4.20 μIU.mL in the observation group were significantly higher than those in the control group, and the proportion of patients with TSH level ranged from<0.27 IU/mL, 0.27 to 1.44 mu IU.rnL and 1.45 to 2.19 IU/mL were significantly lower than those of the control group, the differences were statistically significant (p<0.05). The TSH level of the patients with cervical lymph node metastasis in the observation group were significantly higher than those in the non metastasis group.the TSH level of patients with tumor diameter ranged from 2 to 4 cm and > 4 cm were significantly higher than those patients with < 2 cm, and the diameter of tumor >4 cm of patients was significantly higher than those patients with 2 to 4 cm, the differences were statistically significant (P<0.05). The sensitivity of preoperative TSH combined with Doppler ultrasonography for DTC diagnosis was 73.88% (198/268), specificity was 82.31% (214/260), and accuracy was 78.03% (412/528), which were significantly higher than those of pure ultrasound diagnosis of 57.46% (154/268), 75.77% (197/260), 66.48% (351/528), the differences were statistically significant (P<0.05). The area under the ROC curve of combined diagnosis was 0.847, in which the critical diagnostic value of TSH was 3.153 mlU/L. Conclusion: The DTC patients can be diagnosed by preoperative serum TSH level combined with Doppler ultrasonography effectively, this combined diagnosis can be popularized in clinical practice, so as to play a guiding role in the diagnosis, treatment and disease evaluation of patients with DTC, which is worth to be pay attention. [ABSTRACT FROM AUTHOR]