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Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The implantation of titanium alloy prosthesis would produce stress shielding to damage mechanical microenvironment of bone tissue. This might affect normal bone remodeling process. Interference fit was used to generate preload to reconstruct mechanical microenvironment in this area. It may have important theoretical significance and clinical application value to promote bone remodeling in the mid-long-term after surgery. OBJECTIVE: To analyze the promoting effect of preload on osseointegration of porous titanium alloy prosthesis. METHODS: Fourteen male New Zealand rabbits were divided into two groups. The three-dimensional (3D) printed titanium alloy prosthesis was implanted into the outside of right femoral condyle with interference fit in experimental group (n=7). Rabbits in the control group (n=7) were feed free. Femurs at the surgery side were extracted at 12 weeks after surgery. Micro-CT scanning and 3D reconstruction were performed to measure bone density and trabecular morphological parameters around the prosthesis. Animal experiment was approved by Animal Ethics Committee of Tianjin Institute of Medical Science (approval No. IMPS-EAEP-Z-2019108-01). RESULTS AND CONCLUSION: (1) Bone mineral density was reduced significantly in the experimental group compared with the control group (P < 0.05). (2) Bone volume fraction, trabecular thickness, trabecular number were reduced in the experimental group compared with the control group (P < 0.05). Bone surface area ratio and trabecular separation were larger in the experimental group than those in the control group (P < 0.05). There was no significant change in degree of anisotropy between the two groups (P > 0.05). (3) The results showed that preload could promote osseointegration of porous titanium alloy prosthesis. However, the structural characteristics of the in-growth bone were worse than healthy bone. This might lead to a high fracture risk in the mid-long-term after surgery. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)