1. 可分离式系线磁控胶囊内镜在肝硬化患者中的诊断价值.
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孙焕焕, 卢桂芳, 任莉, 罗玉梅, and 和水祥
- Abstract
Objective To investigate the diagnostic value of detachable string magnetically controlled capsule endoscopy (ds-MCE) in patients with liver cirrhosis. Methods Patients with liver cirrhosis were screened for esophagogastroduodenoscopy (EGD) and ds-MCE examination to assess the accuracy of ds-MCE in identifying gastroesophageal varices, high-risk esophageal varices and portal hypertensive gastropathy using EGD as the gold standard, and evaluate the detection of portal hypertensive enteropathy and the comfort level of patients. Results From May 2021 to July 2022, a total of 53 patients with liver cirrhosis were successfully enrolled. With EGD as the gold standard, ds-MCE detected esophageal varices with 95.45% for sensitivity, 100% for specificity and adjusted positive predictive value (PPV), 95.65% for adjusted negative predictive value (NPV), and 0.877 for Kappa value (P<0.001). For detection of gastric varices, ds-MCE had sensitivity, specificity, adjusted PPV, and adjusted NPV of 93.94%, 90%, 90.38% and 93.69%, and Kappa value of 0.839 (P<0.001). For detection of portal hypertension gastropathy, ds-MCE had sensitivity, specificity, adjusted PPV and adjusted NPV of 80%, 90.70%, 89.59% and 81.93%, and Kappa value of 0.657 (P<0.001). In differentiating high-risk esophageal varices, the sensitivity, specificity, adjusted PPV, and adjusted NPV were 76%, 100%, 100% and 77.43%, respectively; Kappa value was 0.770 (P<0.001). Of the patients with liver cirrhosis, 26.0% (13/50) were diagnosed with portal hypertensive enteropathy. The main mucosal changes were edema, erythema, and vascular dysplasia. The ds-MCE comfort score of 3(2, 4) was higher than that of the traditional EGD 1(0,3) (P<0.0001). Conclusion Compared with EGD, ds-MCE is an accurate, safe, feasible and comfortable method for detecting esophagogastric varices and portal hypertensive gastropathy in patients with liver cirrhosis. It is a potential alternative to EGD screening surveillance of gastroesophageal varices in patients with liver cirrhosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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