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Background Schizophrenia and the use of antipsychotic medications are identified to be the likely contributors to the development of metabolic syndrome (MS) and cardiovascular disease, and jeopardize the prognosis of schizophrenia. Therefore, effectively preventing or reducing the risk of developing MS in patients with schizophrenia is critical. Objective To explore the efficacy of aripiprazole combined with olanzapine for male schizophrenia patients and its effect on MS, so as to provide a certain reference for the selection of antipsychotic drugs for schizophrenia patients. Methods Male patients (n=80) who were hospitalized in The Third People's Hospital of Meizhou from February to June 2023 and fulfilling the International Classification of Diseases, tenth edition (ICD-10) diagnostic criteria for the schizophrenia were enrolled, and grouped using random number table method, each with 40 cases. Study group was treated with aripiprazole combined with olanzapine, while control group was given aripiprazole monotherapy. The treatment lasted for 6 continuous weeks in both groups. At the baseline, Positive and Negative Symptom Scale (PANSS) score, MS-related indices [fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), body mass index (BMI), waist-to-hip ratio (WHR), lipid profile], S100 calcium-binding protein B (S100B) and high sensitivity C-reactive protein (hs-CRP) were recorded. Then the PANSS scores at the end of the 2nd, 4th and 6th week of treatment, the Clinical Global Impression (CGI) scores at the end of the 2nd and 6th week of treatment, as well as the MS-related indices, S100B, hs-CRP, Treatment Emergent Symptom Scale (TESS) score and Rating Scale for Extrapyramidal Side Effects (RSESE) score at the end of the 6th week of treatment were recorded in all participants. Results Analysis on PANSS score revealed a significant group effect, time effect and group×time interaction effect (F=18. 092, 634. 780, 2. 917, P<0. 05 or 0. 01). Analysis on CGI score revealed a significant group effect and time effect (F=20. 492, 99. 190, P<0. 01). At the end of the 6th week of treatment, study group detected lower serum concentrations of HbA1c and triglyceride (TG) compared with control group (t=-3. 495, -3. 293, P<0. 05). The post-treatment hs-CRP level was lower in study group than that in control group (t=-3. 916, P<0. 05). Study group scored lower on TESS compared with control group (t=-4. 684, P<0. 01) . Conclusion Aripiprazole combined with olanzapine can effectively alleviate psychotic states in male schizophrenia patients, and the combination therapy yields less impact on MS-related indices than olanzapine monotherapy. [ABSTRACT FROM AUTHOR]

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Excluding externality from agglomeration, the “∩” curve has been used to depict relationship between agglomeration and pollution. This article includes relationship between pollution and externality from agglomeration of agricultural producer service. Using newly spatial econometrics which can solve the endogenous problem induced by un-observed variable omitted from linear model, the Kuznets curve with spatial structure is constructed based on spatial spillover of externality, which includes double effects from agglomeration of agricultural producer service and its externality. The results show: The “∩” curve can be used to depict relationship between agglomeration of agricultural producer service and pollution, and the “∪” curve can be used to depict relationship between pollution and externality from agglomeration of agricultural producer service. Because of differences between the two curves, we can’t always get the relationship between agglomeration of agricultural producer service and pollution. When lower or higher agglomeration, the impact from agglomeration to pollution is uncertain. And when medium agglomeration, agglomeration makes pollution heavier. [ABSTRACT FROM AUTHOR]

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Southeast University / Dongnan Daxue Xuebao is the property of Journal of Southeast University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Computer Measurement & Control is the property of Magazine Agency of Computer Measurement & Control and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 了解2013、2014年某三级医院抗菌药物的使用情况和常见病原菌的耐药情况。方法 统计2013、2014年小榄医院全院抗菌药物的用药频度(DDDs),并分析临床同期送检标本的细菌培养鉴定以及药敏试验结果。结果 2013年抗菌药物DDDs排名前5位的依次为头孢地嗪(23 805.00)、头孢拉定(14 259.25)、头孢替唑(8 125.58)、甲硝唑(6 581.63)、左氧氟沙星(6 016.60),2014年依次为头孢地嗪(17 818.00)、头孢拉定(15 953.00)、头孢替唑(10 094.75)、头孢硫脒(6 266.00)、左氧氟沙星(6 111.80)。2013年临床分离率为前6位的病原菌为大肠埃希菌(32.75%)、肺炎克雷伯菌(21.01%)、铜绿假单胞菌(15.22%)、白假丝酵母菌(12.95%)、金黄色葡萄菌(10.64%)、鲍曼不动杆菌(7.43%),2014年分别为大肠埃希菌(31.13%)、肺炎克雷伯菌(21.38%)、铜绿假单胞菌(15.75%)、金黄色葡萄菌(15.54%)、白假丝酵母菌(9.17%)、鲍曼不动杆菌(7.04%)。2013、2014年金黄色葡萄球菌和凝固酶阴性葡萄球菌对呋喃妥因、利奈唑胺、万古霉素和奎奴普丁/达福普丁的敏感性高,均较高。与2013年比较,2014年金黄色葡萄球菌对利福平、复方新诺明及四环素的耐药率下降,凝固酶阴性葡萄球菌对青霉素G、克林霉素、红霉素耐药率下降。2013、2014年铜绿假单胞菌及鲍曼不动杆菌对头孢曲松的耐药率均超80%。与2013年比较,2014年大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌及鲍曼不动杆菌对大部分抗菌药物的耐药率均降低。结论 2013、2014年该医院DDDs前3位均为头孢地嗪、头孢拉定、头孢替唑。大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌和鲍曼不动杆菌是分离出的主要革兰阴性杆菌,并且对大部分抗菌药物具有不同程度的耐药。金黄色葡萄球菌是分离出的主要革兰阳性菌,但对多种抗菌药物仍具有较高的敏感性。 [ABSTRACT FROM AUTHOR]