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Objective To systematically evaluate the influencing factors of wound healing in patients undergoing anal fistula surgery, and to provide a theoretical basis for the formulation of reasonable treatment and nursing measures in clinical practice. Methods The computer searched CNKI, Wanfang, VIP Chinese Database, Pubmeide, Enbas, Weber Benschens and Techco Kranali Liberi English databases to collect clinical studies related to the influencing factors of anal fistula wound healing. Studies on the effect of the influencing factors of wound healing in patients undergoing anal fistula surgery were retrieved from CNKI, Wanfang database, VIP database, PubMed, Embase, Web of Science database and The Cochrane Library from the establishment to March 2024. Two trained researchers extracted relevant information according to the inclusion and exclusion criteria, and conducted the Meta-analysis using Revman5. 4 software. Results A total of 19 studies with a total of 2684 patients were included, with a score of ≥6. The results of meta-analysis showed that age ≥60 years old［OR=4. 87, 95%CI (2. 41, 9. 82), P＜0. 001］, alcohol consumption ［OR=0. 19, 95%CI (0. 11, 0. 28), P 6 months ［OR=5. 38, 95%CI (2. 18, 13. 29), P＜0. 05］, complex anal fistula ［OR=5. 38, 95%CI (2. 18, 13. 29), P＜0. 001］, constipation ［OR=3. 50, 95%CI (2. 46, 4. 98), P＜0. 001］, poor stool quality ［OR=4. 88, 95%CI (3. 09, 7. 69), P＜0. 001］, wound postoperative infection ［OR=3. 60, 95%CI (2. 45, 5. 30), P＜0. 001］ and poor wound drainage ［OR=5. 69, 95%CI (2. 50, 12. 97), P＜0. 05］ were independent influencing factors for wound healing in patients with anal fistula after surgery. Conclusion Age(≥60 years old), alcohol consumption, diabetes, anal fistula duration > 6 months, complex anal fistula, constipation, poor stool quality, postoperative wound infection, and poor wound drainage were the influencing factors of postoperative wound healing in patients with anal fistula. This can be used as a reference to strengthen the perioperative assessment and nursing of patients with anal fistula and reduce the incidence of recurrence. (目的 系统评价肛瘘术后患者伤口愈合的影响因素, 为临床制定合理的护理措施提供理论依据。方法 计算机检索中国知网(CNKI)、万方(Wanfang Data)、维普中文数据库(VIP) 、 PubMed、EMbase、Web of Science和 The Cochrane Library英文数据库, 收集影响肛瘘术后伤口愈合相关因素的临床研究。检索时限均为建库至2024年3月。两名研究者独立筛选文献、提取资料并评价纳入文献的偏倚风险后, 采用RevMan5. 4软件进行系统评价。结果 纳入19篇文献, 共2684例患者, 纳入文献评价均≥6分。Meta分析结果显示: 年龄≥60岁［OR=4. 87, 95%CI(2. 41, 9. 82), P＜0. 001］、饮酒［OR=0. 19, 95%CI(0. 11, 0. 28), P＜0. 001］、BMI＜18. 5 kg/m2［OR=4. 99, 95%CI(3. 49, 7. 15), P＜0. 05］、糖尿病［OR=4. 32, 95%CI(2. 26, 8. 25), P＜0. 001］、肛瘘病程＞6个月［OR=3. 23, 95%CI(1. 94, 5. 37), P＜0. 05］、复杂肛瘘［OR=5. 38, 95%CI(2. 18, 13. 29), P＜0. 001］、便秘［OR=3. 50, 95%CI(2. 46, 4. 98), P＜0. 001］、大便性状欠佳［OR=2. 88, 95%CI(1. 80, 4. 33), P＜0. 001］、创面术后感染［OR=3. 60, 95%CI(2. 45, 5. 30), P＜0. 001］、创面引流不畅［OR=5. 69, 95%CI(2. 50, 12. 97), P＜0. 05］为肛瘘患者术后患者伤口愈合的的独立影响因素。结论 年龄≥60岁、饮酒、糖尿病、肛瘘病程＞6个月、复杂肛瘘、便秘、大便性状欠佳、创面术后感染、创面引流不畅是肛瘘患者术后伤口愈合的影响因素。可以此为参考, 加强肛瘘患者围术期评估与护理, 降低复发率发生率。)

为保证多舱体系变电站的钢结构预制舱单元在主变压器火灾下的安全性，提出了一种以蒸压轻质混凝土板作为围护材料的附加防火层构造；该构造基于建筑工业化的发展背景，不仅可在工厂预制，现场施工亦简单快捷。基于碳氢化合物火灾升温曲线，对既有多舱体系变电站所采用的复合墙体及所提出的附加防火层构造进行了时长为3 h的受火试验；其中，5个附加防火层试件的设计考虑了重复受火、钩头螺栓锚固长度、板厚、干密度等级、板材连接方式等参数的影响。结果表明，由于热桥效应，复合墙体试件中的构造钢柱所对应的背火面测点温升在107 min后达180 ℃，无法满足该场景下的隔热性要求；采用所提出附加防火层构造的试件在受火3 h后均可满足隔热性和完整性要求，其中齐口连接形式的最不利试件背火面测点最高温升为143.8 ℃。另外，齐口连接方式较错口连接方式在隔热性及施工便利性方面均具有优势；较短的钩头螺栓锚固长度有助于降低热桥效应；更高的干密度等级有利于提升耐火性；100 mm厚的ALC板已经具有足够的安全冗余。

为开发具有较强耐水性的环保可再生胶黏剂，以环氧大豆油（ESO）为原料，选用顺丁烯二酸酐(MA)为固化剂，乙酰丙酮锌〔Zn(acac)2〕为催化剂，制备ESO木材胶黏剂，同时制备了杨木胶合板，考察了MA添加量对胶黏剂性能的影响，通过DSC分析优化了催化剂添加量，对胶黏剂进行了红外光谱和TG/DTG分析，并利用正交实验对热压工艺进行了优化。结果表明：当MA添加量为27%时胶黏剂性能达到最佳；催化剂的最优添加量为3%；通过红外光谱和TG/DTG分析证明ESO与MA发生了交联固化反应；最佳热压工艺为热压温度150 ℃、热压时间10 min、热压压力2 MPa、涂胶量320 g/m2，在此条件下湿态胶合强度为1.613 MPa，符合国家规定的普通胶合板Ⅱ类板要求（≥0.70 MPa）。该胶黏剂制备方法具有简单、高效、环保等优势,是实现ESO在木材产品生产中可持续应用的一种很有前景的策略,具有很大的工业应用潜力。In order to develop environmentally friendly and renewable adhesives with excellent water resistance, with epoxy soybean oil (ESO) as raw material, maleic anhydride (MA) as curing agent and zinc acetylacetonate (Zn(acac)2) as catalyst, ESO wood adhesive and poplar plywood were prepared. The effect of MA dosage on the performence of adhesive was studied. The catalyst dosage was optimized by DSC analysis, and the adhesive was analyzed by infrared spectroscopy and TG/DTG. Then, the hot-pressing process was optimized by orthogonal experiment. The results showed that the best adhesive performance was achieved at 27% of MA dosage. The optimal dosage of catalyst was 3%. Infrared spectroscopy and TG/DTG analysis proved that ESO underwent crosslinking and curing reaction with MA. The optimal hot-pressing process conditions were obtained as follows: hot-pressing temperature 150 ℃, hot-pressing time 10 min, hot-pressing pressure 2 MPa, and glue spread 320 g/m2. Under these conditions, the wet bonding strength was 1.613 MPa, which was in line with the national requirement of Class Ⅱ ordinary plywood（≥0.70 MPa）. The preparation method of adhesive has advantages such as simplicity, efficiency and environmental friendliness, and it is a promising strategy for achieving sustainable application of ESO in wood product production, with great industrial application potential.

在业务和技术的双重驱动下，通信行业聚焦网络智慧运营，以自智网络为牵引推进网络智慧运营是行业共识。首先，分析了运营支撑系统（operational support system，OSS）是自智网络三层架构的核心，且提升自智网络水平等级的关键是提升OSS智能化能力。其次，详细阐述了OSS产品业务范围界定方法，分析了自智网络牵引的OSS产品的能力短板、提出了OSS产品能力体系化规划提升等具体实施方案，并以宽带业务数字化运营价值场景为例详细描述了该方案。最后，论述了自智网络牵引的OSS智能化能力图谱。面向自智网络提升OSS智能化能力可有效牵引OSS研发方向，指导运营商OSS产品的规划和研发。

目的 探讨院内发生的大血管闭塞性卒中行血管内治疗患者的临床特征、发病机制、血管内治疗及预后，为制订院内大血管闭塞性卒中预防策略提供参考信息。 方法 回顾性分析2020年7月—2023年7月因非缺血性卒中原因在徐州市中心医院住院期间发生大血管闭塞性卒中的45例患者（院内组）的临床资料。选择同期通过急诊绿色通道入院的大血管闭塞性卒中患者100例作为对照（院外组）。收集两组患者的基线资料、实验室指标以及血管内治疗相关资料，比较两组人口学信息、危险因素、发病机制及治疗结局。采用多因素logistic回归分析院内发生大血管闭塞性卒中对患者预后的影响。 结果 院内组大血管闭塞性卒中患者的首诊住院科室主要有脑外科（10/45，22.2%）、心脏外科（9/45，20.0%）、血甲疝外科（9/45，20.0%）及胸外科（5/45，11.1%）等，23例（51.1%）与外科手术有关。两组患者性别、年龄、烟酒史比例、高血压、糖尿病、高脂血症、冠心病、心脏瓣膜病、心功能不全及既往卒中病史差异无统计学意义。与院外组患者相比，院内组患者合并心房颤动（53.3% vs. 19.0%，P＜0.001）、恶性肿瘤（15.6% vs. 1.0%，P=0.002）、其他动脉栓塞（15.6% vs. 1.0%，P=0.002）以及围手术期（51.1% vs. 1.0%，P＜0.001）的比例更高，发病时NIHSS评分更高[21.0（14.5～35.0）分 vs. 18.0（13.5～24.5）分，P=0.019]。院内组的白细胞计数（U=1385.000，P＜0.001）、D-二聚体（U=654.500，P＜0.001）及IL-6（U=1376.000，P＜0.001）水平高于院外组，血红蛋白（U=1758.000，P=0.035）、收缩压（t=-2.766，P=0.006）和舒张压（U=1317.500，P＜0.001）水平低于院外组，差异均有统计学意义。院内组与院外组卒中在前后循环的分布上差异无统计学意义，院内组大动脉粥样硬化性、心源性、其他原因大血管闭塞性卒中患者分别有7例（15.6%）、22例（48.9%）、16例（35.6%），院外组分别有63例（63.0%）、 26例（26.0%）、11例（11.0%），差异有统计学意义（χ2=29.432，P＜0.001）。两组行血管内治疗前缺血区与梗死区的体积比以及术后TICI血流分级、出血转化/造影剂渗出及死亡患者比例差异无统计学意义。与院外组比较，院内组发病到血管内治疗时间及再通时间更短，术中使用补救措施更少 （P＜0.05）。在校正了发病时NIHSS评分、心房颤动、心脏瓣膜病、缺血区与梗死区的体积比后，院内卒中与大血管闭塞性卒中血管内治疗患者的良好预后结局仍呈负相关（OR 0.213，95%CI 0.063～0.711，P=0.012）。 结论 院内外发生大血管闭塞性卒中行血管内治疗的患者有着不同的临床特征、发病机制及治疗结局。院内大血管闭塞性卒中患者的神经系统损伤症状较严重，合并基础疾病较多，病因机制复杂，易预后不良。严格把握手术适应证、预防及控制感染、积极干预危险因素可能会减少院内大血管闭塞性卒中的发生。 Abstract: Objective To investigate the clinical characteristics, pathogenesis, endovascular treatment and prognosis of patients treated with endovascular treatment for large vessel occlusive stroke occurring in hospital, and to provide reference information for the prevention strategies of large vessel occlusive stroke in hospital. Methods A retrospective analysis was performed on 45 patients (in-hospital group) who were hospitalized in Xuzhou Central Hospital for non-ischemic stroke from July 2020 to July 2023 and had large vessel occlusive stroke during hospitalization. During the same study period, 100 patients with large vessel occlusive stroke who entered the emergency greenway of our hospital from outside the hospital were used as control cases (out-of-hospital group). Baseline data, laboratory-related indicators, and endovascular treatment-related data were collected to analyze the demographics, risk factors, pathogenesis, and treatment outcomes of the two groups and compared. Multivariate logistic regression was used to analyze the prognostic effects of patients with large vessel occlusive stroke occurring in hospital. Results Patients with in-hospital large vessel occlusive stroke had a wide variety of first diseases, mainly occurring in brain surgery (10/45, 22.2%), cardiac surgery (9/45, 20.0%), blood nail hernia surgery (9/45, 20.0%), and thoracic surgery (5/45, 11.1%), and 23 cases (51.1%) were associated with surgery. There was no statistically significant difference between the two groups in terms of gender, age, history of smoking and alcohol, hypertension, diabetes mellitus, hyperlipemia, coronary artery heart disease, valvular heart disease, cardiac insufficiency and history of previous stroke. Compared with the out-of-hospital group, more patients in the in-hospital group had a combination of atrial fibrillation (53.3% vs. 19.0%, P＜0.001), malignant tumor (15.6% vs. 1.0%, P=0.002), other arterial thrombosis (15.6% vs. 1.0%, P=0.002), and perioperative period (51.1% vs. 1.0%, P＜0.001), and the NIHSS score at the onset of the disease was higher [21.0 (14.5-35.0) points vs. 18.0 (13.5-24.5) points, P=0.019]. The levels of white blood cell count (U=1385.000, P＜0.001), D-dimer (U=654.500, P＜0.001) and IL-6 (U=1376.000, P＜0.001) in the in-hospital group were higher than those in the out-of-hospital group, and the levels of hemoglobin (U=1758.000, P=0.035), systolic blood pressure (t=-2.766, P=0.006) and diastolic blood pressure (U=1317.500, P＜0.001) were lower than those in the out-of-hospital group, and the differences were all statistically significant. The difference between the in-hospital group and the out-of-hospital group in the distribution of anterior and posterior circulation was not statistically significant. There were 7 cases (15.6%), 22 cases (48.9%), and 16 cases (35.6%) of large vessel occlusive stroke with atherosclerosis, cardiogenic type, and other causes in the in-hospital group, and 63 cases (63.0%), 26 cases (26.0%), and 11 cases (11.0%) in the out-of-hospital group, respectively, with a statistically significant difference (χ2=29.432, P

对16个方钢管超轻混凝土短柱和8个空钢管短柱进行了轴压试验，以超轻混凝土强度和含钢率为变化参数，研究方钢管超轻混凝土短柱的破坏形态和受力性能。结果表明，随着超轻混凝土强度的降低，钢管对核心混凝土的约束效应越强；随着含钢率的增加，构件的承载力和变形能力提高，但当含钢率高于0.25时，超轻混凝土的存在对构件的承载力和变形能力已基本没有影响。基于叠加理论，提出了适用于方钢管超轻混凝土短柱承载力的计算公式。

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为了对蛋黄酱产品的开发及品质评价提供数据支持和参考，以8种市售蛋黄酱为原料，对其主要成分、粒径、微观结构、流变特性、质构特性、色泽、乳液稳定性和热稳定性进行了测定。结果表明：市售蛋黄酱粗脂肪含量为49.00%～73.70%，pH为3.37～4.08，粒度〔D（4，3）〕分布在4～12 μm之间；蛋黄酱以乳滴的形式存在，为典型的水包油型结构；蛋黄酱的流变学性质表明蛋黄酱为剪切变稀的假塑性流体，弹性模量(G′)远大于黏性模量(G″)，呈现出类弹性固体性质；质构分析表明蛋黄酱具有较高的黏度和良好的涂抹性；市售蛋黄酱的亮度（L*）、红值（a*）、黄值（b*）和总色差（ΔE*）差异显著；8种蛋黄酱的乳液稳定性和热稳定性高，有利于蛋黄酱的储存和使用。 n order to provide data support and reference for the development and quality evaluation of mayonnaise products, the main components, particle size, microstructure, rheological properties, textural properties, color, emulsion stability and thermal stability were determined using eight kinds of commercially available mayonnaise as raw materials. The results showed that the crude fat content of commercially available mayonnaise was 49.00%-73.70%, the pH was 3.37-4.08, and the particle size distribution\[D(4,3)\] was 4-12 μm. Mayonnaise existed in the form of emulsions, a typical oil-in-water structure. The rheological properties of mayonnaise showed that mayonnaise was a shear-thinning pseudoplastic fluid, and its elastic modulus (G′) was much larger than its viscous modulus (G″), showing an elastic solid-like property. The texture analysis showed that mayonnaise had high viscosity and good spreadability. The commercially available mayonnaise differed significantly in brightness (L*), red value (a*), yellow value (b*) and total color difference (ΔE*). The emulsion stability and thermal stability of eight kinds of mayonnaise were high, which was beneficial to the storage and use of mayonnaise.

共振隧穿二极管（RTD）可编程逻辑门是一种由单双稳态转换逻辑单元（MOBILE）及正、负输入分支组成的阈值逻辑电路。基于二进制神经元模型中的三层网络结构，提出了基于RTD可编程逻辑门的n变量函数实现算法。按照汉明距离由大到小的顺序，搜索最优输入向量，用定理1或定理2方法产生隐层函数，通过变换次数，确定输入向量的真假及隐层函数的权重。由于定义了最优输入向量及变换次数，提高了算法的准确性；又由于采用了定理2方法，令设计的电路更简单。

Aiming at the technical problems of "untimely perception, poor transmission and difficult equipment deployment" in the monitoring and early warning of mountain disasters in the complex environment of the Qinghai-Tibetan Plateau, a UAV-throwing monitoring device, LoRa networking and edge computing gateway, as well as other embedded hardware and software equipment applicable to deformation and micro-motion monitoring of high-level and high-risk mountain disasters were developed, and focused on the research of the system low-power adaptive data acquisition algorithm and RF frequency adaptive technology, were developed the self-organised network routing algorithm based on LoRa and Beidou RDSS, as well as the multimodal communication intelligent switching technology, so as to solve the problems of timeliness of data perception in complex environments and the problems of lowpower consumption and environmental adaptability. The results show that the developed system had a good on-site pilot application effect, which meeting the requirements for long-term monitoring of mountain disasters in alpine mountainous areas, and the average packet loss rate of data transmission in extreme environments is 2. 328 8 percent, providing new technologies and methods for disaster prevention and mitigation in the construction and operation of major projects in alpine and complex mountainous areas. [ABSTRACT FROM AUTHOR]

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目的　观察人工卵母细胞激活剂钙离子载体在卵细胞质内单精子注射受精 (ICSI) 后不受精或低受精患 者再次助孕中的应用效果。方法　选择第1次 ICSI 助孕出现胚胎不受精的夫妻 12 对及低受精的夫妻 38 对。女方 (后称患者) 再次进行 ICSI 助孕, 助孕时使用钙离子载体辅助卵母细胞激活, 比较患者前后两次助孕的一般指标［促 性腺激素 (Gn) 用量、获卵数、成熟中期Ⅱ卵母细胞 (MⅡ卵) 率、人绒毛膜促性腺激素 (HCG) 日子宫内膜厚度］、胚胎 发育情况 (正常受精率、卵裂率、可用胚胎率、优质胚胎率) 、临床妊娠结局 (着床率和临床妊娠率)。结果　胚胎不受 精或低受精患者前后两次助孕的 Gn 用量、获卵数、M II卵率、HCG 日子宫内膜厚度比较差异均无统计学意义 (P 均>0. 05)。胚胎不受精患者第 1 次助孕的正常受精率为 0, 第 2 次正常受精率为 47. 53% (77/162) 、卵裂率为 84. 42% (65/77) 、可用胚胎率为 52. 31% (34/65) 、优质胚胎率为 38. 24% (13/34)、着床率为 45. 45% (5/11) 、临床妊 娠率为 57. 14% (4/7) 。胚胎低受精患者第2次的正常受精率、可用胚胎率、优质胚胎率、着床率和临床妊娠率均高 于第1次 (P均<0. 05) 。结论 ICSI后不受精或低受精患者再次行ICSI助孕时给予钙离子载体可提高卵母细胞利用 率和受精率, 并改善胚胎发育和临床妊娠结局。 [ABSTRACT FROM AUTHOR]

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To efficiently track the evolving Pareto frontier in dynamic multiobjective optimization problems over time or environment, this paper proposed a new dynamic multiobjective optimization algorithm, called HDDMOEA, based on environment sensing and prediction correction. This algorithm incorporated three main strategies. Firstly, it employed the Wilcoxon signed rank test to detect environmental changes and introduced a new environment sensing operator to determine the intensity of these changes. Secondly, it constructed the Holt differential prediction correction model to predict the positions of population individuals in the next time window, making corrections based on a reference point during the prediction process to enhance prediction accuracy and accelerate the search speed of the algorithm. Then, it introduced a new mutation method that injected different mutated individuals based on the intensity of environmental changes to maintain population diversity, thus reducing the likelihood of the population falling into local optima. To verify HDDMOEA's effectiveness, researchers conducted comparative analysis between HDDMOEA and five advanced prediction algorithms on the FDA and dMOP test sets. The results demonstrate that HDDMOEA effectively and dynamically balances the diversity and convergence of populations during the search process, continuously tracking the Pareto frontier and outperforming the other five comparative algorithms. [ABSTRACT FROM AUTHOR]

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为了解栖息地和气候变化对北树鼩（Tupaia belangeri）活动的影响，于2012年8月—2013年7月采用红外相机技术对广西弄岗国家级自然保护区15 hm2森林动态监测样地及其周边区域内的北树鼩进行监测，采用核密度估计、重叠指数及相对活动强度指数分析其日活动节律及季节性变化规律。结果表明：北树鼩的日活动节律模式属于晨昏活动类型（日活动高峰期：07：00—08：00、16：00—17：00）。不同月份间北树鼩的活动强度指数（t=13.072，df=11，P

风电场、光伏电站和储能系统的容量优化规划是降低风光储多能源混合系统成本、保证系统可靠性的有效措施之一。依托山体的重力储能，可以风光储多能源混合系统中风电场容量、光伏电站容量和储能系统容量为决策变量，建立以系统总成本最小和包括风光互补特性、供电自给损失率及风光储多能源混合系统贡献率等因素的综合指标最优为目标函数的多目标容量优化规划模型，并利用多目标自适应混沌粒子群算法求解模型。基于此，考虑不同规划偏好，利用逼近理想解排序法对帕累托前沿进行排序，得到不同规划偏好下的最优规划方案。另外，利用熵权法定权的秩和比评价方法对不同规划方案的可靠性指标进行了评价，并选取某典型日对规划方案的运行状态进行分析。仿真结果表明，所提模型具有良好的经济性及可靠性，为风光储多能源混合系统在不同偏好下的规划提供了参考。

恶性黑色素瘤 (MM) 极易发生区域和远处转移, 通常预后很差。早期未转移的MM应手术切除, 对于晚期 MM患者, 免疫疗法提高了大多数MM患者的生存率。细胞毒性T淋巴细胞相关蛋白4 (CTLA-4) 、程序性死亡受体1 (PD-1) 、淋巴细胞激活基因3 (LAG-3) 等免疫检查点的发现改变了肿瘤治疗的模式, 免疫检查点抑制剂如 CTLA-4 阻 断剂伊匹木单抗、PD-1阻断剂纳武利尤单抗和帕博利珠单抗、LAG-3阻断剂瑞拉利单抗等, 能够明显改善晚期MM 患者的预后, 其协同应用时进一步增强了抗肿瘤作用和免疫反应, 提高了MM免疫治疗的疗效。MM免疫治疗的效 果受到众多因素的影响, 主要包括遗传因素、细胞因子、MicroRNA、肠道微生物群和肿瘤代谢等, 仍有很大比例患者 的免疫治疗效果无法获得令人满意。 [ABSTRACT FROM AUTHOR]

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