Objective To investigate the associations between welding fume metal composition and thyroid function of occupational workers, and to provide the evidence for early protection of occupational injury among welders. Methods A total of 484 workers (223 CO, gas shielded welders, 261 auxiliary workers) in a vehicle manufacturing enterprise who participated in occupational health examination were: selected using a cluster sampling method in April 2022. The; concentrations of metals in the; air of work places and urine: of operational workers were: detected by inductively coupled plasma emission spectrometry and inductively coupled plasma mass spectrometry, respectively. Triiodothyronine: (TT3), thyroxine: (TT4), free: thyroxine: (FT4), frex: triiodothyronine: (FT3) and thyroid stimulating hormone: (TSH) were: detected by fully automated chemiluminescence assay. The: associations between metals and thyroid function were analyzer! by generalized linear regression, when: urinary metals were: corrected using creatinine. Results The: primary metals in wedding fumes were: chromium (Cr), cropper (Cu), iron (Fc), manganese: (Mn), nicked (Ni) and tellurium (Tc:). Their concentrations were: 10. 19 pig/m³, 40. 38 p, g/m³, 1 658. 06 pig/m³, 155. 37 pig/m³, 7. 94 pig/m³and 6. 94 pig/m³, respectively, which were: significantly higher than those: in the: control areas. The: exceedance rate: of Mn in electric wedding posts was 60% (>0. 15 mg/m³). The: urinary concentrations of Cr, Mn, Ni and Tc: in welders were: 0.09, 1.08 X 10 2, 0. 13 and 0.72 X 10 2 p,g/mmcd creatinine, respectively, higher than those: of auxiliary workers (all with P <0.05). Urinary Mn and Tc: concentrations were positively correlated with scrum FT3 [$(95%CI) =0.03(0.01 -0.06)] and FT4 (0(95%C/) =0.02(0.00 - 0.04)], respectively (both P <0. 05). Conclusion The main components of the welding fumes produced by CO2 gas shielded welding are Or, Mn, Fc, Ni, Ou and Tc. Exposing to Mn and Tc is associated with elevated thyroid hormone levels. [ABSTRACT FROM AUTHOR]