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目的比较常规体外受精（IVF）和卵胞质内单精子注射（ICSI）两种不同授精方式对解冻移植第六天（D6）囊胚患者妊娠结局的影响。方法回顾性队列研究分析中山大学附属第三医院生殖中心2018年1月至2020年4月期间解冻移植第六天囊胚移植患者的临床资料，按受精方式分为常规IVF组（446例）和ICSI受精组（200例）。按是否有第五天（D5）囊胚移植史，分为仅有D6囊胚冷冻及移植的患者，以及有D5囊胚移植史的患者。比较两组患者基本资料、囊胚质量及妊娠结局。结果IVF组和ICSI组患者BMI，不孕年限，基础FSH差异均无统计学意义（P > 0.05）。ICSI组患者年龄小于IVF组患者，原发性不孕的比例高于常规IVF组，获卵数和正常受精卵子数高于常规IVF受精组（P < 0.001）。常规IVF组五期和六期囊胚比例高于ICSI组（21.6 % vs. 3.14 %， P < 0.001）。ICSI组ICM评分为A级的囊胚高于IVF组（23.8 % vs. 14.3 %， P = 0.01）。ICSI组HCG阳性率和临床妊娠率均高于IVF组（65.5 % vs. 48.4 %， P < 0.001； 56 % vs. 41.3 %， P = 0.001），ICSI组胚胎种植率和活产率也高于常规IVF组（43.8 % vs. 30.9 %， P < 0.001； 43.0 % vs. 31.8 %， P = 0.006）。校正两组间年龄、获卵数等影响因素后，ICSI组临床妊娠率仍高于常规IVF组（OR：1.590， 95 % CI： 1.030， 2.455， P = 0.036）。ICSI组出生婴儿体质量低于IVF组（P = 0.016），早产率、性别比与分娩方式在两组间差异无统计学意义。结论ICSI受精的D6囊胚解冻移植后的临床妊娠率高于常规IVF受精的D6囊胚，活产率有升高的趋势，可能与IVF与ICSI病人导致囊胚发育慢的因素不同有关。ICSI受精的D6囊胚解冻移植后相对好的妊娠结局，可在一定程度上弥补ICSI周期囊胚发育相对较慢导致的妊娠结局的差异。

广义预编码辅助空间调制在每一个时隙内通过选择激活接收天线组合来传递空间维度信息比特。在相同频谱效率和信噪比的情况下,相比于传统的广义空间调制系统,广义预编码辅助空间调制系统的误比特性能有显著提升。同时,针对广义预编码辅助空间调制系统现有的检测算法具有较高的计算复杂度的问题,提出了一种基于广义预编码辅助空间调制的分组检测算法。仿真结果表明,该算法的检测性能接近最大似然检测算法,且复杂度显著降低。

首先简单介绍对 DWDM系统的考虑 ,重点强调光纤的非线性效应 .然后介绍了康宁公司开发的大有效面积光纤 LEAF○R.主要内容包括 LEAF○R光纤的折射率分布设计、典型光学特性、有效面积及其测量方法和 LEAF○R光纤在通信系统中的应用

掺铒光纤放大器（简称ＥＤＦＡ）和波分复用（简称ＷＤＭ）技术在光通信系统中的应用，将光纤的信息载运容量提高了若干个数量级。由于光放大器的高输出功率和多个波长的同时传输，光纤的非线性效应和色散已经成为系统性能的主要限制因素。对于目前使用的常规单模光纤来说...

Copyright of Nonferrous Metals (Extractive Metallurgy) is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Rehabilitation Medicine is the property of China Association of Rehabilitation Medicine, China-Japan Friendship Hospital and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective To explore the optimal method for separating and purifying small extracellular vesicles from the supernatant of mesenchymal stem cells. Methods Three standard extracellular vesicle separation procedures, including differential (ultra) centrifugation (dUC), polyethylene glycol (PEG) precipitation and QIAGEN kit method, were compared; small extracellular vesicles were extracted through ultrafiltration concentration and filtration with a 0.22 µm or 0.45 µm filter membrane, respectively, based on the standard procedure. The quality of the extracted extracellular vesicles and the efficiency of the separation methods were analyzed by comparing the operation duration and simplicity of the separation methods, and evaluating the morphological structure, particle size distribution and marker protein expression of small extracellular vesicles through transmission electron microscopy, nanoparticle tracking analysis technology (NTA) and Western blot, respectively. The CCK⁃8 assay and Transwell migration assay were used to evaluate the effects of small extracellular vesicles extracted by the modified methods on the proliferation and migration of breast cancer cells. Results Small extracellular vesicles could be isolated by all these three methods, and the QIAGEN kit method has the shortest operation duration, 48 min on average, and up to 93 min after ultrafiltration concentration (P<0.0001). The PEG precipitation method had the longest operation duration, 487 min on average, and up to 547 minutes with additional ultrafiltration concentration step (P<0.0001). The average operation duration of the dUC method was 217 minutes; after the addition of the ultrafiltration conentration step, it was up to 274 minutes (P<0.0001). The typical "saucer" structure was observed in all samples under transmission electron microscopy, and the particle sizes of each sample ranged between 30 and 200 nm except for that in the QIAGEN kit method, which was above 200 nm. Among them, the dUC+0.45 µm filter membrane group had the largest number and the most complete small exbracellular vesicles structures in one field of view. Western blot results showed that positive marker proteins CD9, CD63 and TSG101 were expressed in the samples extracted by different methods, but the negative marker calnexin was not expressed. However, after 0.22 µm filter membrane filtration, the bands of small extracellular vesicle marker proteins became shallow. The NTA results showed that the proportion of small extracellular vesicles filtered by dUC+ 0.45 µm filter membrane was the highest, reaching 94.86%. The particle size distribution maps of samples extracted by different methods showed that the NTA results of dUC standard and the dUC+0.45 µm filter membrane groups showed a unimodal and smooth curve. Samples filtered by dUC+0.45 µm filter membrane were selected for breast cancer cell phenotype experiment, and the results showed that cell proliferation and migration were enhanced (all P<0.05). Conclusions dUC is an effective method for separating small extracellular vesicles from mesenchymal stem cells. The quality of small extracellular vesicles can be improved by filtering the cell supernatant with 0.45 µm filter membrane before ultracentrifugation. [ABSTRACT FROM AUTHOR]

Objective To analyze the drug resistance of Mycobacterium tuberculosis in Qinghai Province, to provide scientific basis for the diagnosis, treatment, and prevention and control of tuberculosis in Qinghai Province. Methods A total of 1 836 culture-positive strains in pulmonary tuberculosis patients from eight cities (prefectures) in Qinghai Province from 2017 to 2021 were selected for drug resistance testing using the proportion method for isoniazid (I), rifampicin (R), streptomycin (S), ethambutol (E), ofloxacin (0), and kanamycin (K). Results Among the tested strains, 462 were found to be drug-resistant, with an overall drug resistance rate of 25.16%. The primary drug resistance rate was 23.84%, and the acquired drug resistance rate was 38.89%. The rate of extensively drug-resistant tuberculosis was 5.85%. The drug resistance rates of the six anti-tuberculosis drugs from high to low were as follows: I (15.74%), S (12.58%), R (9.15%), E (5.56%), 0 (4.74%), and K (1.63%). The rate of multi-drug resistant tuberculosis (MDR-TB) was 7.46%, with a primary MDR rate of 5.97% and an acquired MDR rate of 22.84%. There were differences in drug resistance rates (光2=25.645, P<0.001) and MDR rates (光2=13.578; P=0.009) in different years, as well as differences in drug resistance rates (%2=16,865, PcO.001) and MDR rates (x2=7.068, P-0.029) among urban, agricultural, and pastoral areas. Conclusion The drug resistance rates of Mycobacterium tuberculosis isolated in Qinghai Province, especially the rates of primary drug resistance and MDR-TB, are relatively high, showing an increasing trend year by year. The drug resistance rates are particularly high in pastoral areas. This suggests the need to strengthen standardized treatment for tuberculosis patients, as well as the standardized use of second-line drugs and patient follow-up management. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Ecology & Rural Environment is the property of Journal of Ecology & Rural Environment Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to strengthen the detection and monitoring of space targets, especially non-cooperative targets, more and more attention has been paid to the characteristics of space targets. The position, velocity, attitude, angular velocity and material complex refractive index of space target were inversely estimated by unscented Kalman filter (UKF). The observation angle, photometric and degree of polarization data were used as the observation values to estimate the state of the target. Based on the position and velocity kinematics model and the attitude and angular velocity dynamic model, the time evolution of the five states was completed, and the joint estimation of the five state parameters was realized. The simulation results show that setting reasonable initial state value, state equation and measurement equation noise, the errors of five state parameters can converge reasonably, and UKF can better predict the five characteristic parameters of space targets. At the same time, it is also verified that the observation angle, luminosity and polarization data can be used to retrieve the five indirect observation characteristic information of space moving targets. [ABSTRACT FROM AUTHOR]

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Copyright of Food & Fermentation Industries is the property of Food & Fermentation Industries and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Ophthalmology & Otorhinolaryngology is the property of Eye & ENT Hospital of Fudan University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探索基于 BOPPPS理念的以案例为导向的教学法(CBL)混合式教学模式在临床基础检 验技术实习教学中的应用效果。方法 选取在广西医科大学第一附属医院检验科实习的2020—2023届四年 制医学检验技术专业的实习生作为研究对象,2020—2021届的53名实习生为对照组,采用传统教学方式; 2022—2023届的 49名实习生为干预组,实施基于 BOPPPS理念的 CBL 混合式教学模式。实习结束后,采取 教学质量考核及问卷调查等形式对教学效果进行评估。结果 干预组教学质量考核总成绩[(77.82±5.27) 分]明显高于对照组[(69.08±7.57)分],差异有统计学意义(P<0.05)。2组在学习目标明确与重点难点突出上 比较,差异无统计学意义(P>0.05);在学习目标明确、有助于促进主动学习、有助于理解和掌握学习内容、有助于 提高临床实践能力、感到学习压力大方面比较,差异均有统计学意义(P<0.05)。结论 基于 BOPPPS教学理念 的CBL教学模式应用于临床基础检验技术课程,取得了良好的教学效果,在今后教学中可以进行广泛地应用。 [ABSTRACT FROM AUTHOR]

Objective To explore the mechanism of Guominjian on atopic dermatitis(AD) based on net- work pharmacology and molecular docking techniques. Methods The active ingredients and corresponding targets of Guominjian were retrieved from TCMSP database, and AD disease related targets were obtained from OMIM, GeneCards and DrugBank database. Cytoscape3. 7. 2 software was used to construct the Chinese medicine component target network and STRING platform for protein interaction network analysis. GO function and KEGG signal pathway database were used for enrichment analysis, active ingredient-target-pathway network was constructed, and molecular docking was performed with AutoDock Vina software. Results There were 123 common targets of Guominjian and AD. GO functional enrichment analysis involved 641 items of biological processes, 68 items of cell components and 129 items of molecular functions. The signaling pathways including MAPK, NF-κB, TNF-α, JAK-STAT and PI3K-Akt, etc. were selected by enrichment analysis of KEGG signaling pathways. The results of molecular docking showed that quercetin and kaempferol had high affinity with FOS, TNF, TGFBI, HIF-1A and IL-1A. Conclusion Guominjian can treat AD from multi-target and multi-pathway, which providing theoretical basis for further basic experimental research. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Anhui Agricultural Sciences is the property of Journal of Anhui Agricultural Sciences Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Basic & Clinical Medicine is the property of Editorial Office of Basic & Clinical Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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