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Copyright of Journal of Ordnance Equipment Engineering is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Myocardial infarction is one of the most serious cardiovascular diseases at present, and the existing clinical treatment options such as thrombolytic therapy, percutaneous coronary intervention and coronary artery bypass grafting cannot fully restore the myocardial damage caused by ischemia. Stem cell-derived exosomes for the treatment of myocardial infarction have been a hot research topic in recent years, but the low yield of natural-derived exosomes, the difficulty and time consuming nature of obtaining them, and the poor homing effect have limited their clinical application. In this context, the construction of artificial exosomes as an alternative to natural exosomes has become an effective strategy to solve the above problems. OBJECTIVE: To expound the research status of artificial exosomes in the treatment of myocardial infarction, and classify them into two design modes: semiartificial and full-artificial, and discuss the research progress and problems of the two modes, finally, make the evaluation and prospect of its clinical application in the future. METHODS: PubMed and CNKI were searched for relevant articles with “artificial exosomes, myocardial infarction, engineering” in Chinese, and “artificial exosome, hybrid exosome, myocardial infarction, nanoparticle, drug delivery system” in English. The focus of the search was from January 2017 to December 2022, and some of the classic forward literature was included. A preliminary selection was conducted through reading titles and abstracts. Repetitive studies, low-quality journals and irrelevant articles were excluded. Finally, 73 articles were included for review. RESULTS AND CONCLUSION: (1) By semi-artificially modifying exosomes, whether it is the modification of targeting peptides, hybridization of biofilms or the assistance of magnetic substances, traditional exosome therapies with insufficient targeting and low retention rate and easy to be cleared by the reticuloendothelial system have improved the efficiency of traditional exosome therapy for myocardial infarction. However, these strategies have problems such as unclear modification efficiency, medical ethics, and biotoxicity. (2) Fully artificial bionic exosomes have a higher degree of design freedom compared to exosome modification, which can solve the problems of high extraction and storage difficulties of exosomes of natural origin and limitations of large-scale production; however, this artificial exosome strategy still lacks reliable preclinical data support and biosafety testing, and has not yet formed a standardized process required for large-scale production; therefore, before applying to the clinic, the artificial exosome solution as an alternative to natural exosomes still needs continuous in-depth research by researchers. [ABSTRACT FROM AUTHOR]

Copyright of Tunnel Construction / Suidao Jianshe (Zhong-Yingwen Ban) is the property of Tunnel Construction Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Chongqing University of Posts & Telecommunications (Natural Science Edition) is the property of Chongqing University of Posts & Telecommunications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Thyroid cancer(THCA) is a common malignant tumor of the head and neck, and the incidence rate has increased year by year in recent years.The risk factors of THCA are not clear, and relevant studies have shown that this may be related to demographic factors, environmental factors, genetic and epigenetic factors, among which epigenetic factors are the research hotspots in the pathogenesis of THCA in recent years.In this paper, RNA methylation factors in epigenetics were reviewed, in order to further reveal the pathogenesis of THCA,understand its prognosis and hereditability, and provide a basis for the accurate and scientific prevention and control of THCA. [ABSTRACT FROM AUTHOR]

To solve the problem of reservoir damage in coalbed methane development, a hyperbranched polymer temporary plugging agent MTA was developed based on the theory of reservoir protection by temporary plugging. The synthesis of MTA involves the use of raw materials such as methyl methacrylate, methyl acrylic anhydride and tert-carboxyl betaine etc. The performance of MTA was evaluated in laboratory experiment. IR spectroscopy shows that the three monomers have successfully copolymerized to form a new polymer. The thermal decomposition temperature of MTA is 252 ℃. Physical-chemical performance analysis results show that MTA has a molecular weight of 6 × 104, an amine number of 17.52, a pH of greater than 7.0 and an average particle size of 0.69-3.32 μm. Compared with the commonly used plugging agents, MTA has better ability in reducing pressure transmission. The capacity of MTA in inhibiting the swelling of clays is equivalent to the inhibitive capacity of polyamines; it reduces the interlayer space of a clay from 1.92 nm to 1.58 nm. Under the action of a differential pressure, MTA can plug the micropores in formation rocks to stop the invasion of water into the formation. Furthermore, MTA can be adsorbed onto the surfaces of a rock by the action of electric charges, thereby forming a layered structure to hinder the filtration of water molecules into the rock. Evaluation of MTA reveals that MTA has good compatibility with other additives in a working fluid, and reduces the amount of filtrate of the work fluid by 41.2%. At 150 ℃, MTA working fluid has excellent performance sustainability and contamination resistance; it is resistant to contamination by 10% NaCl, or 5% CaCl2, or 10% clays of poor quality. Rock samples treated with the MTA fluid have their permeability recovered by 87.3%. In field operations, MTA showed excellent performance in maintaining borehole stability; the rate of hole washout was less than 5%. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Beijing University of Technology is the property of Journal of Beijing University of Technology, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A large number of tunnels under construction and proposed to be constructed face the challenge of hazardous gases from non-coal strata, and clarifying the formation mechanism of hazardous gases in non-coal strata tunnels is the basis for solving this problem. Based on this, the latest progress of the research on the formation mechanism of noxious gases in non-coal strata tunnels in China was reviewed, the main types of noxious gases in non-coal strata were summarized, the influence mechanism of geological conditions on the formation of noxious gases was discussed, the breeding mechanism of noxious gases was analyzed, and the research direction of noxious gases in non-coal strata tunnels was prospected. The study shows that: non-coal stratigraphic tunnels can be broadly classified into tectonically connected, peritectic metamorphic and integrated types according to their genesis. Geological formations such as large fractures, folds and deep circulating hydrothermal high-temperature conductive zones play a key role in the formation, storage and spillage of harmful gases in the peritectic rocks of non-coal stratigraphic tunnels. The sources of CH2, H2 S and CO2 are similar, but the differences in their physicochemical properties lead to different mechanisms of their. The formation mechanisms of CH2, H2 S and CO2 are different due to their different physicochemical properties. The complex geological formations, the breeding and transport modes of hazardous gases in tunnel enclosures of composite components, and the coupling mechanisms of solid-liquid-thermal-force are worth further study. The study has positive implications for the practice and research on the prevention and control of harmful gases in tunnel enclosures of non-coal strata. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electric Power Automation Equipment / Dianli Zidonghua Shebei is the property of Electric Power Automation Equipment Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shaanxi University of Science & Technology is the property of Journal of Shaanxi University of Science & Technology Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Railway Investigation & Surveying is the property of Railway Investigation & Surveying Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ballistics / Dandao Xuebao is the property of Journal of Ballistics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Oxidative stress plays an important role in the pathological process of osteoarthritis, leading to local inflammation and matrix degradation. Previous studies have shown that antioxidants such as quercetin and vitamin C are potential candidates for treating osteoarthritis. OBJECTIVE: To determine whether quercetin, vitamin C and desferrioxamine mesylate mixture can delay disease progression in rats with post-traumatic osteoarthritis. METHODS: The anterior cruciate ligament was cut off in 10 Sprague-Dawley rats to induce osteoarthritis. Animal models were randomized into two groups (n=5 per group). Twenty weeks after operation, 50 μL of normal saline or antioxidant mixture was slowly injected into the affected joint, once a week for 4 successive weeks. The antioxidant mixture consisted of 1 g/L dihydroxyquercetin, 30 g/L vitamin C and 200 mg/L desferrioxamine mesylate. Gait analysis was performed before treatment, 1 week and 5 weeks after treatment. Micro-CT examination and histology scoring were performed 5 weeks after treatment. RESULTS AND CONCLUSION: Gait analysis showed that intra-articular injection of antioxidant mixture did not improve pain-related limb laziness index (P=0.449). However, 5 weeks after treatment, the limb laziness index in the treatment group was significantly lower than that in the control group (P=0.047). Five weeks after treatment, microcomputed tomography analysis showed that there was no significant difference in any parameters between the treatment group and the control group (P > 0.05). There were severe histopathological changes of osteoarthritis in both groups. The Osteoarthritis Research Society International scores showed no significant difference in both groups (P=0.382). In conclusion, intra-articular injection of antioxidant mixture containing quercetin, vitamin C and desferrioxamine does not delay the progress of osteoarthritis in patients with advanced osteoarthritis. Future studies should aim to determine whether administration of antioxidants and prolonged drug retention time in early osteoarthritis can effectively delay the progress of osteoarthritis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Ballistics / Dandao Xuebao is the property of Journal of Ballistics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Engineering Mechanics / Gongcheng Lixue is the property of Engineering Mechanics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to solve the problem that the traditional data management platform is difficult to make management decisions on river system quickly and comprehensively, it is of great significance to construct a big data platform of river system by using big data technology. This paper discussed the big data platform from three aspects of the characteristic of big data of river system, the structure of big data platform of river system and the realization of big data platform of river system. It put forward the platform constructed by Hadoop-based framework, driven by information integration model, river health diagnosis model, risk warning model and decision support model and braced by big data of river system. Generally, the paper provides a new idea for the efficient management of river system to realize the diagnosis and risk warning of river health. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Explosives & Propellants is the property of Chinese Journal of Explosives & Propellants Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of Beijing Institute of Technology is the property of Beijing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Harbour Engineering is the property of Editorial Office of China Harbour Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Transactions of Beijing Institute of Technology is the property of Beijing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The experiment of stretched rod copper explosion formed projectile ( EFP) formed by the shaped charge penetrating into main target add-on typical explosive reactive armor( ERA ) with different oblique angle were conducted to reveal the effect of sandwich ERA on penetration efficiency of EFP. The pulsed X-ray photographs of the interaction between ERA and EFP were obtained by flash X-ray experiment, together with residual depth of penetration ( RDOP) of residual EFP. The results show that RDOP has a nonlinear decreasing tendency as oblique angle raises. The drop of penetration depth of EFP passing through ERA exponentially increases with ERA oblique angle. When the oblique angles of ERA are 0° and 30°, RDOP and drop of penetration depth keep stabile. But when il grows from 30° to 60°, RDOP declines from 0.50 D to 0. 19 D., and the drop of penetration depth grows rapidly from 41% to 77% . On the other hand , the increment of layer thickness results in a heavier reduction in RDOP and the increase in the drop of penetration depth. ERA with 0. 027 D layer thickness makes the drop of penetra-lion depth higher 8% on average than it with 0. 018 I). The reason for KDOP reduction is analyzed for researching ihe mechanism of action of FFP and ERA. [ABSTRACT FROM AUTHOR]