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Copyright of Chinese Journal of Oncology is the property of Chinese Journal of Oncology / Zhonghua Zhongliu Zazhi and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To observe the value of electroacupuncture nerve stimulation therapy combined with pelvic floor muscle training in the rehabilitation of early cervical cancer after extensive total hysterectomy. Methods: 98 patients with early cervical cancer undergoing extensive total hysterectomy who were admitted to our hospital from March 2020 to October 2021 were prospectively collected. They were divided into study group and control group by random number table method. The control group was instructed to conduct pelvic floor muscle training, and the study group was given electroacupuncture nerve stimulation therapy on the basis of pelvic floor muscle training. The incidence of urinary retention and the recovery of bladder function, immune function and pelvic floor function were compared between the two groups. Results: The results of 13 weeks after operation showed that the normal rate of comprehensive muscle strength of pelvic floor muscle in the study group was higher than that in the control group (P<0.05). Initial urinary bladder volume (VS), maximum urinary flow rate (MFR) and maximum urinary bladder volume (MVS) in two groups at 13 weeks after operation were higher than those at 1 week after operation, while residual urine volume (PVR) was lower than that at 1 week after operation. FVS, MFR and MVS in the study group at 13 weeks after operation were higher than those in the control group, while PVR was lower than that in the control group (P<0.05). The levels of serum immunoglobulin A (Ig A), immunoglobulin G (Ig G),immunoglobulin M (Ig M), peripheral blood T lymphocyte CD3+, CD4+/CD8+in the two groups at 13 weeks after operation were higher than those at 1 week after operation, and the study group was higher than the control group (P<0.05). The incidence of urinary retention in the study group was 4.08% (2/49) lower than 22.45% (11/49) in the control group, and the difference was statistically significant (P<0.05). Conclusion: Electroacupuncture nerve stimulation therapy combined with pelvic floor muscle training can reduce the incidence of urinary retention in patients with early cervical cancer after extensive total hysterectomy, improve pelvic floor function and bladder function, and promote the recovery of immune function, and with good effect. [ABSTRACT FROM AUTHOR]

Copyright of China Tropical Medicine is the property of China Tropical Medicine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the role of leukemia inhibitory factor receptor ( LIFR) and Hippo-YAP signaling pathway in the lung metastasis of cervical cancer. Methods ① The real-time fluorescence quantitative polymerase chain reaction ( qRT-PCR) was used to detect the expression of LIFRmRNAin the primary cancerous tissues，adjacent non-cancerous tissues and metastasis tissues from 50 cases of patients with cervical cancer and lung metastasis.② Recombinant lentiviral plasmid containing LIFRor its negative control ( vector) were used to infect the human cervical cancer cell line SiHa. After screening with 2. 0 #g/mL puromycin， the cells that stably expressed LIFR ( observation group) or vector (control group) were obtained. Western blotting was used to detect the expression of LIFRand Hippo-YAP signaling pathway related proteins YAP，P-YAP，TAZ，and p-TAZ. The cells of the two groups were injected into the BALB/c nude mice through the tail vein. After 4 weeks，the nude mice were killed and the lung tissue was removed for HE staining. The number of all the metastases in the lung tissues was counted microscopically. Results ① The relative expression of LIFR mRNA in the primary tumor was higher than that in the adjacent non-cancerous tissues，and the relative expression of LIFR mRNAin the metastasis tissues was lower than that in primary tumor and adjacent non-cancerous tissues ( all !< 0. 05 ). ② The relative expression of LIFR，p-YAP and p-TAZ proteins in the SiHa cells which overexpressed LIFRwas higher than that in the control cells ( all !< 0. 05 ) . There was no significant difference in YAP and TAZ protein expression between the control group and observation group ( all !> 0. 05 ). The lung metastases in the SiHa cells with overexpressed LIFR and control cells were 9 ± 2 and 60 ± 5，respectively ( all !< 0. 05 ) . Conclusion Overexpression of LIFR can promote the phosphorylation of Hippo-YAPsignaling pathway proteins YAPand TAZ $ and then inhibit tlie formation of lung metastasis of cervical cancer cells. [ABSTRACT FROM AUTHOR]