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目的总结我国南方城市肺毛霉菌病（PM）的临床特征及预后，同时探讨宏基因组二代测序（mNGS）在PM诊断中的价值。方法回顾性分析中山大学附属第一医院2019年1月1日至2022年1月31日期间诊断为PM且曾行mNGS检测的病例，共纳入14例，确诊 4例，临床诊断10 例，收集其临床表现、诊治及预后资料。结果所有患者均有基础疾病，血液系统恶性肿瘤和糖尿病最常见。最常见的症状是发热（10例）、咳嗽（9例）和气促（9例）。胸部CT形态以实变影最多见，其次为肿块影，多伴空洞。实验室检查方面，CD4+T淋巴细胞下降、CD8+T淋巴细胞升高以及CD4+/CD8+比下降提示预后不良。CT影像学合并胸腔积液的患者预后更差。mNGS诊断的阳性率为 78.5 %，明显高于组织病理（50%）及肺泡灌洗液深部真菌快速荧光染色直接镜检（61.5%）、真菌培养（23.1%）。结论肺毛霉菌病好发于有基础疾病或免疫功能低下患者，临床表现缺乏特异性，较低的CD4/CD8 比率及CT影像学合并胸腔积液的患者预后更差，mNGS诊断PM快速便捷、敏感性高，在诊断PM中具有优势。

针对毫米波和传统蜂窝频段场景下频谱效率和传输可靠性较低的问题,文章提出了一种三维散射簇多天线信道模型以分析大规模多输入多输出（MIMO）系统性能。文章假设仰角和方位角分别遵循拉普拉斯和Von-Mises分布,推导出均匀平面阵列天线各单元之间空间相关系数的解析表达式,最后建立MIMO多天线系统模型并分析其系统性能。研究了仰角功率谱中不同角度扩展对均匀平面阵列衰落相关性和信道容量的影响,以及不同信噪比和天线阵元数对频谱效率的影响。分析结果与传统的均匀线性阵列进行比较表明,在毫米波场景下,均匀平面阵列比均匀线性阵列更适用于大规模MIMO系统,这使未来的移动网络工作在不同频段和蜂窝小区成为可能。

水下通信是无线传输的一个关键研究领域,而声音信号是目前水下通信的最佳候选者。正交频分复用（OFDM）技术有助于在水声（UWA）信道上进行数据高速率传输。文章提出了一种在UWA信道中的基于分数傅里叶变换（FRFT）的OFDM系统,并且在不同子载波数量、调制方案以及多普勒频率条件下将其与传统OFDM系统进行了性能对比和评估。研究结果表明,尽管FRFT的计算顺序与快速傅里叶变换（FFT）相同,但在所有多径场景下,基于FRFT的OFDM系统的性能都优于传统OFDM系统,且满足UWA信道对系统复杂度低和功耗小的需求。

【目的】观察过敏性及非过敏性哮喘发病过程中2型固有免疫细胞（ILC2）的差异，探讨ILC2与哮喘临 床评价指标的相关性。【方法】研究对象来自我院2017年6月至2018年1月的过敏性和非过敏性哮喘患者，收集相 应临床基线资料并评估病情、进行血常规、肺功能等检查；应用流式细胞术检测外周血ILC2；通过ELISA和多因子检 测分别测定总IgE及sIgE和Th2型细胞因子。【结果】哮喘（Asthma）组的ILC2比例和计数与嗜酸性粒细胞（EOS）计 数及sIgE 正相关（r=0.37，0.32，0.56，0.57；P

Objective To study the best forming process of Huangqi Jianzhong Decoction Granules. Methods Taking the difficulty of preparing soft materials and granulation, as well as formability and solubility of particles as evaluation indexes, this paper carried out orthogonal test to optimize the forming process of particles. The drying temperature of wet particles was screened by taking particle formability and water content as evaluation indexes. Results The optimum forming process of Huangqi Jianzhong Decoction Granules was as follows：the ratio of drug to the starch to the dextrin was 1:1:1, wetting agent was 75% ethanol, and its dosage was 28%. The optimum drying temperature of wet granules was 60 ℃ . Conclusion In this study, the forming process of Huangqi Jianzhong Decoction Granules was optimized. The method was reasonable and feasible, which could provide scientific basis for the preparation of Huangqi Jianzhong Decoction Granules. [ABSTRACT FROM AUTHOR]

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Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The entity omission is a typical problem of distantly supervised named entity recognition. Entity omission in the training set provides incorrect supervision information during model training, model will be more inclined to predict this type of entity as a non-entity when subsequently predicting entity types, resulting in a decline in the model s entity recognition and classification capabilities, and affects the generalization performance of the model. To deal with the problem, this paper proposed a incorporating similarity negative sampling for distantly supervised named entity recognition. Firstly, it calculated and scored the similarity between the candidate samples and the labeled entity samples. Secondly, it sampled the candidate samples based on the similarity score, and sampled the samples participating in the training. Compared with the random negative sampling method, this method reduced the possibility of sampling missing entities by combining similarity calculations, thereby improving the quality of training data and thus improving the performance of the model. Experimental results show that compared with other models on the three data sets of CoNLL03, Wiki, and Twitter, compared with the baseline model, the proposed model achieved an average F₁ value improvement of about 5 percentage points. It is proved that this method can effectively alleviate the problem of performance degradation of the named entity recognition model caused by missing entities under distantly supervised conditions. [ABSTRACT FROM AUTHOR]

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chemical Engineering of Oil & Gas / Shi You Yu Tian Ran Qi Hua Gong is the property of PetroChina Southwest Oil & Gas Field Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Due to the large number of blind individuals and the shortage of donor corneas available for transplantation, artificial corneas have gradually become a research hotspot, However, artificial corneas often experience implant tearing due to insufficient mechanical properties. In order to solve this problem, researchers at home and abroad have tried to improve the mechanical properties of corneal repair materials by a series of research work. This paper summarizes the progress relating to the mechanical properties of four common natural polymer-based corneal repair materials, namely collagen, gelatin, silk fibroin, and chitosan. The results show that physical methods such as photo-crosslinking and thermal crosslinking, chemical methods such as 1(3-dimethylaminopropyl) -3-ethylcarbodiimide (EDC)/N-hydroxysuccinimide (NHS) crosslinking, genipine or glutaraldehyde crosslinking and other composite methods can significantly improve the mechanical properties of corneal materials, but these methods still have some shortcomings. Therefore, further development of high-quality artificial corneas is crucial. It is hoped that the article can provide some reference and ideas for the study of improving the mechanical properties of corneal repair materials through summarization. [ABSTRACT FROM AUTHOR]

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Copyright of Shandong Medical Journal is the property of Shandong Medical Health Newspapers and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

目的 探讨丁苯酞注射液对动脉瘤性蛛网膜下腔出血（aneurysmal subarachnoid hemorrhages，aSAH） 患者早期脑损伤的作用与机制。 方法 收集2017年8月-12月期间急性发病的aSAH患者66例，均在动脉瘤破裂后予以介入栓塞术治 疗。入组患者随机分为观察组、对照组各33例。对照组术后常规药物及对症支持治疗，观察组在常 规治疗的基础上加用丁苯酞注射液，100 ml，Q12 h，静脉滴注，两组病例均连续治疗7 d。分别于发病 1 d、3 d和7 d测定患者血清一氧化碳（nitric oxide，NO）、血清内皮素血管肽-1（endothelin-1，ET-1）、血 清神经特异性烯醇酶（neuron specific enolase，NSE）、血清C反应蛋白（C-reactive protein，CRP）、血清 细胞内黏附分子-1（intercellular adhesion molecule-1，ICAM-1）、血清白细胞介素-1β（Interleukin-1，IL-1β） 的水平，并且在发病第4周记录两组患者迟发性脑梗死的发生情况，改良Rankin评分量表的评分。 结果 观察组发病3 d、7 d的血清NO水平高于对照组，3 d、7 d血清ET-1、NSE、CRP、ICAM-1、IL-1β的 水平低于对照组，差异均具有统计学意义。发病4周观察组改良Rankin评分量表≤2分的比例高于对照 组，差异具有统计学意义。两组迟发性脑梗死发生无显著差异。 结论 aSAH后使用丁苯酞注射液能够降低与早期脑损伤相关的炎性因子水平，改善此类患者的预后。 Abstract: Objective To investigate the effect and mechanism of Butyphthalide injection on early brain injury in patients with aneurysmal subarachnoid hemorrhages (aSAH). Methods From August 2017 to December 2017, a total of 66 patients with acute aSAH were enrolled in the study. They were all treated by interventional embolization after aneurysm ruptured. They were randomly divided into observation group and control group, and 33 cases in each group. The control group received routine medication and symptomatic support treatment. The observation group was given intravenous Butyphthalide injection in addition, 100 ml, Q12 h. All the patients were treated continuously for 7 days. The levels of serum nitric oxide (NO), serum endothelin-1 (ET-1), serum neuron specific enolase (NSE), serum C reactive protein (CRP), serum intercellular adhesion molecule-1 (ICAM-1) and serum interleukin-1β (IL-1β) were determined on day 1, 3 and 7 after onset in both groups, and delayed cerebral infarction and modified Rankin scale (mRS) score were observed in all patients of two groups. Results The levels of NO in observation group were higher than that in control group on day 3 and 7, while the levels of ET-1, NSE, CRP, ICAM-1and IL-1β were all lower than that in control group on higher than that in control group, with statistical significance. There was no significant difference in delayed cerebral infarction incidence between two groups. Conclusion Using Butyphthalide after aSAH can reduce early brain injury, improve the prognosis of such patients. Decreasing inflammatory factors production using Butyphthalide may play a role on amelioration of focal brain injury.

Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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The exact solutions to the space-time fractional Fokas-Lenells equations with parameters in nonlinear optics were obtained by means of the complete discrimination system for polynomial method, including rational function solutions, periodic solutions, solitary wave solutions, Jacobi elliptic function solutions and hyperbolic function solutions. The relevant graphs of the exact solutions were drawn, and the influence of parameters on the structure of the solution was analyzed. [ABSTRACT FROM AUTHOR]

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Relaxor ferroelectric single crystals with perovskite (ABO3) structure possess excellent electromechanical coupling properties and are considered as the key materials of next-generation medical ultrasound transducers, high-precision piezoelectric actuators, and underwater acoustic transducers. According to the existing fundamental science and material preparation issues in relaxor ferroelectric crystals, this manuscript reviews the research progresses on the crystal growth and property optimization of relaxor ferroelectric singles in recent years. This review covers the following aspects: new crystal growth methods for enhancing the uniformity of composition and properties; new methods to improve the piezoelectric properties of relaxor ferroelectric single crystals; the control of ferroelectric domain structure to achieve high-light transmittance of relaxor ferroelectric crystals; the application of high-performance relaxor ferroelectric single crystals in the field of electro-optical technology. [ABSTRACT FROM AUTHOR]