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Adreno-cortical carcinoma (ACC) is an uncommon tumor, some of them may produce excessive steroid hormone. The prognosis of ACC is quite poor and current treatment options are relatively limited, especially for patients whose tumor is metastatic and difficult to remove by surgical operation. This makes the management of ACC challenging. Existing studies have shown that the mechanisms of ACC are complex. The molecular changes happen in adrenocortical development and homeostasis may explain the occurrence of ACC. This review focuses on recent studies and summarizes the genetic and molecular mechanism changes that potentially associated with ACC in the development process of the adrenal cortex and multi-omics studies, including genomic changes, epigenetic changes, differences in non-coding RNA, immune microenvironment and features found through multi-omics analysis. This information may support screening of therapeutic targets of ACC in future. [ABSTRACT FROM AUTHOR]

Objective To investigate the expression of C/EBPδ in colorectal cancer and its effect on the proliferation of colorectal cancer cells. Methods The expression of C/EBPδ protein in 40 patients undergoing the radical resection of colon cancer in the Second People’ s Hospital of Yunnan province from 2017 to 2018 was detected by immunohistochemistry. The interaction between C/EBPδ and Siah2 in colorectal cancer tissues was detected by immunoprecipitation. Viral vectors with C/EBPδ overexpression and interference were constructed to infect colorectal cancer caco-2 cells，respectively. The effects of C/EBPδ expression and interference on cell proliferation，apoptosis and cycle were observed through CCK8，flow cytometry detection and plate cloning formation experiments. Chi-square test was used to analyze the correlation factors of positive expression rate. Results I The expression of C/EBPδ increased successively from the normal intestinal tissues to paracellular tissues and then to colorectal cancer tissues，and the differences were statistically significant （all P < 0.05）. The expression of C/EBPδ protein was more significant in colorectal cancer patients with liver metastasis；II The C/EBPδ increased colorectal cancer tissues were accompanied by the increase of Saih2，and there was an interaction between the two；III C/EBPδ overexpression significantly increased the proliferation of caco-2 cells， while the shRNA interference of C/EBP significantly reduced the proliferation of colorectal cancer cells；IV Compared with the control group，the shRNA interference of C/EBPδ significantly inhibited the in vitro migration and invasion of colorectal cancer cells caco-2. Conclusion C/EBPδ is abnormal in colorectal cancer tissues，and the overexpressed C/EBPδ promotes the invasion and rotation of colorectal cancer cells by interacting with Saih2， which may be related to the poor prognosis of colorectal cancer. [ABSTRACT FROM AUTHOR]

Objective To discuss the efficacy of early enteral nutrition in preventing rehaemorrhagia in cirrhosis patients who received therapeutic endoscopy after gastrose ophageal variceal Bleeding（GEVB）． Methods 105 cirrhosis patients who received therapeutic endoscopy after GEVB were randomly divided into two groups， the treatment group （EEN group， n= 72） and the control group （Regular diet group，n＝33）．Both of the two groups would have food after 24 hours from receiving therapeutic endoscopy， and then to compare the difference of rehaemorrhagia between the two groups in 6 weeks after operation．Results Compared with the control group， rehaemorrhagia rate of the treatment group decreased obviously. And it was statistically significant（P＜0.05）． Conclusion Early enteral nutrition given to patients who received therapeutic endoscopy after GEVB could decrease or ameliorate rehaemorrhagia. [ABSTRACT FROM AUTHOR]