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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Electrical stimulation is an effective treatment plan for peripheral nerve injuries, but different frequencies of electrical stimulation have different mechanisms and applications for promoting peripheral nerve recovery. OBJECTIVE: To systematically sort out and summarize the roles and applications of different frequencies of electrical stimulation in the treatment of peripheral nerve injuries, and to deeply analyze the advantages and disadvantages of various methods in order to find the most beneficial treatment strategy for patients’ nerve recovery METHODS: Computer-based searches were conducted in the China National Knowledge Infrastructure (CNKI) and PubMed databases from the inception of the databases to May 2024. The search terms included “peripheral nerve injury, electrical stimulation, low frequency electrical stimulation, medium frequency electrical stimulation, high frequency electrical stimulation, TENS, interfering electricity, short wave, ultrashort wave, frequency” in both English and Chinese. Ultimately, 74 relevant documents were included for analysis. RESULTS AND CONCLUSION: Peripheral nerve injury, a common clinical disease, can cause sensory and motor dysfunction in patients. Low-frequency electrical stimulation can promote cell proliferation and accelerate the expression of nerve growth factor within the cell after electrical stimulation, promote macrophage recruitment and infiltration, accelerate the clearance of myelin debris, and promote myelin regeneration of damaged axons. Medium-frequency electrical stimulation can act on deeper tissues and is better for relieving neuropathic pain. High-frequency electrical stimulation can promote the proliferation of Schwann cells and macrophages, inhibit inflammatory factors, and rapidly recruit cells to the site of nerve injury, accelerating the speed of nerve repair. Different frequencies of electrical stimulation have their own advantages in promoting the recovery of peripheral nerve injuries, but there are still some issues, such as differences in the site of electrical stimulation and the treatment plans for various disease types. [ABSTRACT FROM AUTHOR]