Objective: To analyze the risk factors of deep venous thrombosis (DVT) in lower extremities, and to explore the clinical efficacy of catheter-contact thrombolysis in the treatment of DVT. Methods: 126 cases of DVT in lower extremities patients who were treated in Beijing Jishuitan Hospital from December 2015 to December 2018 were selected as the case group of this study, and 60 volunteers for physical examination in our hospital during the same period selected as control group . The risk factors of DVT in lower extremities were analyzed by multivariate logistic regression analysis. The case group was randomly divided into two subgroups: systemic thrombolysis group (treated with systemic thrombolysis) and catheter thrombolysis group (treated with catheter-contact thrombolysis), with 63 cases in each group. The curative effect of two groups were evaluated, and the circumference difference of lower limbs and venous patency score of two groups before treatment and 1 month after treatment were observed. The treatment time, hospitalization time, the dosage of urokinase and the occurrence of adverse reactions were recorded and compared between the two groups. Results: There were significant differences in age, body mass index (BMI), red blood cell count (RBC) and surgical trauma history between the case group and the control group (P<0.05). Multivariate logistic regression analysis showed that age, BMI, RBC and surgical trauma history were independent risk factors for DVT in lower extremities (P<0.05). The cure rate of catheter thrombolysis group was 57.14% (36/63), which was higher than that of systemic thrombolysis group 33.33% (21/63) (P<0.05). 1 month after treatment, the bilateral thigh circumference difference, circumference difference of bilateral calf and venous patency scores of the two groups were significantly reduced, and the above indexes of catheter thrombolysis group were significantly lower than those of systemic thrombolysis group. The treatment time and urokinase dosage in catheter thrombolysis group were significantly lower than those of systemic thrombolysis group, but the hospitalization time was significantly longer than that of systemic thrombolysis group (P<0.05). There was no significant difference in incidence of adverse reactions between the two groups (P>0.05). Conclusion: Age, BMI, RBC and history of surgical trauma were independent risk factors for DVT in lower extremities, the efficacy of catheter-contact thrombolysis for DVT in lower extremities is significantly, which has good safety [ABSTRACT FROM AUTHOR]