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某网架因施工遗留问题和使用荷载的增大，导致结构存在质量安全隐患。系统地介绍了网架加固方案：受压杆件采用薄壁槽钢、薄壁矩形管或角钢作为外加约束单元的增大截面法进行加固，受拉杆件采用新增双拼槽钢的增大截面法进行加固，螺栓采用在原螺栓球节点上焊接鼓筒节点或增设高强对拉螺杆的方法进行加固。采用MST和NIDA软件进行了结构模型验证并使用直接分析法对网架进行承载力计算，并对压杆加固方案进行了精细化有限元分析，对比分析了加固杆件和未加固杆件的荷载-位移曲线和破坏模式。结果表明：压杆加固后，构件承载力提高了15%~33%，破坏模式由失稳破坏向强度破坏转变；整体加固完成后，在荷载增加并考虑初始缺陷和整体缺陷的情况下，网架结构可以满足《建筑结构可靠性设计统一标准》（GB 50068—2018）的要求。

目的研究环形 RNA circ_0120051对心肌成纤维细胞的纤维化表型的调控作用和机制。方法通过实时萤光定量PCR（RT-qPCR）检测健康器官捐献者（n=24）与心力衰竭（HF）病人（n=21）心肌标本中 circ_0120051及其宿主基因溶质载体家族8成员A1（SLC8A1）的表达水平。核糖核酸外切酶（RNase R）消化实验鉴定circ_0120051的RNA稳定性。RT-qPCR检测circ_0120051在人心肌细胞AC16中的核质分布情况。利用腺病毒在C57BL/6乳小鼠心肌成纤维细胞（mCFs）中过表达circ_0120051，通过RT-qPCR和Western blot检测过表达circ_0120051对mCFs中纤维化相关基因表达的影响，利用细胞划痕实验检测对mCFs迁移能力的影响。通过RNA免疫共沉淀技术（RIP）验证circ_0120051与miR-144-3p间的结合作用，利用双萤光素酶报告基因实验鉴定miR-144-3p与靶基因异柠檬酸脱氢酶2（Idh2） 3’-UTR的结合位点。结果Circ_0120051在心衰病人心肌中表达显著增加，而其宿主基因SLC8A1表达无显著差异。Circ_0120051主要定位于人心肌细胞的胞质中。RNase R消化实验证实circ_0120051相对于线性SLC8A1 mRNA具有典型的环状RNA稳定性。过表达circ_0120051可抑制mCFs中纤维化相关基因表达和mCFs的迁移能力。RIP实验证实circ_0120051与miR-144-3p之间具有明显结合作用。在mCFs中转染miR-144-3p可促进纤维化相关基因的表达，并有效逆转circ_0120051对mCFs纤维化表型的抑制作用。双萤光素酶报告基因实验证实miR-144-3p与Idh2的3’-UTR存在结合作用。miR-144-3p可在转录水平抑制mCFs中Idh2表达，而过表达circ_0120051可增加mCFs中IDH2表达。在mCFs中转染miR-144-3p和Idh2的小干扰RNA（siRNA），可一致性地逆转circ_0120051对纤维化相关基因表达和mCFs迁移的抑制作用。结论Circ_0120051通过特异结合miR-144-3p并增加其靶基因IDH2表达来发挥抑制mCFs纤维化表型的作用。

A Holling-Ⅱ predator-prey diffusion model with fear effect and modification under homogeneous Dirichlet boundary conditions is studied. Firstly, the prior estimation of the model is given by applying the maximum value principle and comparison theorem. Then, by calculating the fixed point index of the cone map, the sufficient condition for the existence of the positive solution is obtained. When H is sufficiently large, the stability of the positive solution is discussed according to the linear stability theory. Finally, by means of spectral analysis and branching theorem, the existence and stability of local branching solutions are discussed with m as the branching parameter.(研究了在齐次Dirichlet边界条件下一类具有恐惧效应及修正的Holling-Ⅱ捕食者-食饵扩散模型。首先，利用极大值原理和比较定理给出模型的先验估计；然后，通过计算锥映射不动点指标，得到正解存在的充分条件，且根据线性稳定性理论，讨论了当H充分大时正解的稳定性；最后，借助谱分析和分支定理，以m为分支参数，讨论了局部分支解的存在性与稳定性。)

目的探究环形RNA circSLC8A1_005调控心肌成纤维细胞纤维化表型的作用及可能机制。方法利用腺病毒介导在小鼠心肌成纤维细胞（mCFs）中过表达circSLC8A1_005，并检测mCFs中纤维化相关因I型胶原α1链（Col1a1）、Ⅲ型胶原α1链（Col3a1）和平滑肌肌动蛋白α2（Acta2）基因表达，通过EdU和划痕实验检测不同干预对mCFs的增殖和迁移能力的影响。双萤光素酶报告基因实验检测circSLC8A1_005包含的潜在核糖体进入序列（IRES）的活性。通过Western blot实验检测circSLC8A1_005翻译蛋白SLC8A1-605aa及其在细胞内分布情况。双萤光素酶报告基因实验检测SLC8A1-605aa对超氧化物歧化酶2（Sod2）的转录激活作用。通过RNA结合蛋白免疫沉淀（RIP）实验检测SLC8A1-605aa与Sod2 mRNA的结合作用。放线菌素D实验检测SLC8A1-605aa对Sod2 mRNA稳定性的影响。结果利用腺病毒可在mCFs中有效介导过表达circSLC8A1_005，过表达circSLC8A1_005可显著抑制mCFs中纤维化相关基因表达，抑制mCFs的增殖和迁移能力。双萤光素酶报告基因实验结果提示circSLC8A1_005包含的2个IRES具有活性。Western blot检测结果显示circSLC8A1_005可翻译预期大小为70 ku的SLC8A1-605aa蛋白，并主要分布于细胞核内。过表达SLC8A1-605aa和circSLC8A1_005可一致地抑制mCFs的纤维化表型。SLC8A1-605aa可特异上调超氧化物歧化酶2（Sod2）表达，但并不能转录激活Sod2表达；RIP实验结果显示SLC8A1-605aa与Sod2 mRNA有特异结合作用，而放线菌素D实验结果显示SLC8A1-605aa能够增强Sod2 mRNA的稳定性。结论CircSLC8A1_005通过翻译蛋白SLC8A1-605aa发挥抑制心肌成纤维细胞纤维化表型的作用，SLC8A1-605aa可能是潜在的用于心肌纤维化治疗的靶点。

能源互联网的建设不仅需要技术手段的支撑，更需要以价值为驱动激活各方主体参与，打造互惠共赢的能源生态圈。为此，从能源、信息和制度经济学的视角出发，深入分析能源互联网的价值创造机理、业态创新范式和发展战略选择。首先，剖析了能源互联网的价值创造机理，其本质是以多能融合突破孤立系统的边界，从而显著扩大资源优化配置的空间；通过信息技术使得能源系统更加有序，进而促进能源系统的“熵减”；通过能源互联网平台释放范围经济的巨大红利。其次，设计了基于共享经济机制、降低交易成本、激励共享共赢的能源互联网价值分配机制，谋划了能源互联网支撑智慧城市发展、支撑绿电追踪、支撑能源消费节能降耗、提升工业资产利用率、助力政府治理的新业态。最后，策划了以再电气化为核心目标、基于价值公平分配的数据共享、以数字孪生为平台的人工智能、以负荷调度替代需求侧响应、基于共享经济的能源互联网市场机制的发展战略。

对3片足尺镁晶板覆面的带刚性斜撑的冷弯薄壁型钢剪力墙进行水平单调和低周往复加载试验,以测试该种冷弯薄壁型钢剪力墙的抗侧性能。通过试验观测了该种剪力墙的破坏过程,获得了墙体的单调荷载-位移曲线、滞回曲线及骨架曲线,并对结构的延性、耗能能力、抗剪承载力、刚度退化及破坏特征进行分析。试验结果表明:边柱屈曲后墙体的刚度迅速降低,墙板在接缝处以及边柱处逐渐与骨架分离,标志着试件发生破坏。在实际工程中,此种墙体应使用与边柱刚度相适配的抗拔件,采用整面覆板并加强接缝处及边柱上的螺钉连接。最后,将试验结果与其他文献中剪力墙的力学性能进行对比,结果表明,试验墙体在保证具有较高抗侧承载力的情况下仍具有较好的延性及耗能性能。

风电固有的随机性使其难以在长时间尺度上被准确预测，且预测误差随预测时间的延长而增大，导致用于抑制风电随机性的储能控制策略往往与实际需求偏差较大。为了有效应对风电的动态随机性，应用由不同响应能力及容量的储能单元组成的混合储能系统，提出一种基于多时间级分层思想与模型预测控制（model predictive control,MPC）理论相结合的混合储能分层MPC优化策略，实现对风电和储能的精准控制。在对风电进行周期预测的基础上构建储能分层动态响应优化模型，上层优化利用大功率慢速响应储能单元在长时间尺度上对风电进行能量转移，下层优化利用小功率快速响应储能单元在短时间尺度上平滑风电波动，且上层优化结果作为下层优化的状态变量。通过分层MPC，不同时间级的风电周期预测信息不断滚动更新，各层间的储能优化控制也可得到有效协调。针对微网中的风储联合发电系统，通过改变分层MPC的滚动时域及步长，得到适用于算例的最优参数。仿真结果验证了该策略可以动态响应风电变化，并有效改善风储系统输出的峰谷特性和波动性。

随着国家电网的快速发展,大型电力通信网向光传送网（OTN）组网快速演进以支撑电网管理、运维中的大量数据通信需求。大型的OTN组网具有长距离光通信的特点,光信噪比（OSNR）是衡量网络质量的重要参数,为保证高效传输,系统OSNR计算具有重要的研究与应用意义。文章针对长距离OTN电力通信网,分析了网络拓扑的特点,提出了基于该网络特点的OSNR计算方法,并分析了该计算方法的特点、意义及推广价值。

全同弱光栅通过时分/波分混合复用时,光栅阵列中的阴影效应、多重反射等对反射信号会产生影响。对全同弱光纤光栅阵列所作的时域反射信号仿真计算和分析表明,阴影效应和多重反射不会引起光栅中心波长漂移,但会导致光栅中心波长处的反射强度降低。若阵列中的单个光栅的反射率较高,受阴影效应的影响,光栅阵列远端的光栅将可能检测不到,不能达到增加光栅复用数量的目的;但若单个光栅的反射率太低,则又会使阵列上的光栅的被测反射信号强度降低,从而增加了信号检测难度。

Copyright of Telecommunication Engineering is the property of Telecommunication Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To explore the psychological development process of suicide ideation-to-action in male prisoners, providing a basis for suicide prevention and intervention for them. Methods: Thirty-five male prisoners with self-reported or prison police assessment of suicide risk and history of self-injury and suicide were selected for in-depth interviews. Using grounded theory to code data, explore the evolution process and influencing factors of prisoners from suicidal ideation to suicide-related actions. Results: Prisoners were divided into three stages from the emergence of suicidal ideation to suicide-related actions, namely the seed stage of cumulative environmental effects (stage 1), the germination and development stage of suicidal ideation (stage 2), and the action strategy selection stage (stage 3). The process mainly contained 4 dimensions, namely situational risk factors, negative psychological experiences, psychological risk factors and psychological protection factors. Conclusion: The suicide psychological development process of prisoners is a gradual process. Suicide intervention should prioritize prevention, remove risk factors, enhance protective factors, and carry out personalized intervention based on different pathways. [ABSTRACT FROM AUTHOR]

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Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of University Chemistry is the property of Peking University, College of Chemistry & Molecular Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Objective: To investigate the relationship between systemic inflammatory response index (SII), serum thymidine kinase 1 (TK1), C-reactive protein/albumin (CRP/ALB) ratio and postoperative recurrence and metastasis in patients with triple negative breast cancer (TNBC). Methods: 268 TNBC patients admitted to the Affiliated Hospital of Xuzhou Medical University from January 2018 to May 2020 were selected and divided into recurrent metastasis group and non recurrent metastasis group according to whether they had recurrent metastasis 3 years after surgery. Calculated preoperative SII, CRP/ALB ratio and detected serum TK1 level. The factors of postoperative recurrence and metastasis in TNBC patients were analyzed by multivariate Logistic regression, the predictive value of SII, serum TKI and CRP/ALB ratio for postoperative recurrence and metastasis in TNBC patients was analyzed by receiver operating characteristic (ROC) curve. Results: After 3 years of follow-up, the recurrence and metastasis rate of 268 TNBC patients was 25.00% (67/268). Compared with non recurrence and metastasis group, the SII, serum TKI and CRP/ALB ratio in recurrence and metastasis group increased (P<0.05). Independent risk factors for postoperative recurrent metastasis in TNBC patients were TNM stage III, lymph node metastasis and SII, serum TKI, and an elevated CRP/ALB ratio P<0.05). The area under the curve of SII, serum TKI and CRP/ALB ratio in predicting postoperative recurrence and metastasis of TNBC patients was 0.917, which was greater than 0.789, 0.779 and 0.781 predicted by SII, serum TKI and CRP/ALB ratio alone. Conclusions: The increase of SII, serum TKI and CRP/ALB ratio are closely relate to the recurrence and metastasis of TNBC patients after operation, the combination of SII, serum TKI and CRP/ALB ratio has a high predictive value for the recurrence and metastasis of TNBC patients after operation. [ABSTRACT FROM AUTHOR]

Objective: To investigate the relationship between the expression of NUAK family SNF1-like kinase 1 (NUAKI) and NUAK family SNF1-like kinase 2 (NUAK2) protein and clinicopathological features and prognosis in non-specific invasive breast cancer (IBC-NST). Methods: 132 patients with IBC-NST admitted to the Affiliated Hospital of Xuzhou Medical University from June 2018 to June 2020 were selected. Detected the expression of NUAK2 and NUAKI proteins in cancer tissue and adjacent tissues, the relationship between the expression of NUAK2, NUAK1 protein in cancer tissues and clinicopathological features were analyzed. IBC-NST patients were followed up for 3 years after discharge, the survival difference between patients with negative and positive expression of NUAK1 and NUAK2 were analyzed by Kaplan-Meier survival curve, the factors affecting the prognosis of IBC-NST patients were analyzed by multivariate COX regression analysis. Results: Compared with adjacent tissues, IBC-NST had a higher positive expression rate of NUAK2 and NUAKI proteins in cancer tissues (P<0.05). The positive expression rates of NUAK2 and NUAKI proteins in IBC-NST cancer tissue were related to the degree of differentiation, TNM staging, and lymph node metastasis (P<0.05). The 3-year progression-free survival (PFS) rate in IBC-NST patients with NUAKI positive expression was lower than that in IBC-NST patients with NUAKI negative expression (P<0.05), and the 3-year PFS rate in IBC-NST patients with NUAK2 positive expression was lower than that in IBC-NST patients with NUAK2 negative expression (P<0.05). Risk factors for poor prognosis in IBC-NST patients included NUAKI positive expression, lymph node metastasis, and NUAK2 positive expression (P<0.05). Conclusion: The positive expression rates of NUAKI and NUAK2 proteins in IBC-NST cancer tissue are significantly increased. The positive expression of NUAK1 and NUAK2 proteins is related to the degree of differentiation, lymph node metastasis, TNM staging, and poor prognosis. [ABSTRACT FROM AUTHOR]

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Copyright of Science Technology & Engineering is the property of Chinese Society of Technology Economics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore a motor-related brain computer interface (BCI) technology based on the decoding of six precise hand movements. Methods Based on the analysis of the mechanisms and response characteristics of six common types of fine motor electroencephalography (EEG) in the hand, a BCI paradigm for fine motor execution was designed. A motion related EEG signal decoding model based on convolutional neural networks was implemented, and a BCI system based on fine motor was built. Six types of fine motor gesture EEG signals from eight healthy subjects and two patients with significant motor dysfunction due to lesions involving the parietal lobe were classified. Results The classification accuracy of EEG signals in 10 subjects under the BCI system based on fine hand movements was (79.20±6.05)%. Conclusions The BCI method based on decoding six types of fine hand movements has certain effectiveness and generalization ability. [ABSTRACT FROM AUTHOR]

Using Coefficient of Variation and GIS spatial analysis, we detected the spatial and temporal evolution and development patterns of border trade in Yunnan counties, analyze the de‐ velopment pattern of border trade in depth by combining with the model of border trade develop‐ ment level, and explore the driving mechanism of border trade by using geographic probes. The results show that: ① the overall trend of county border trade in Yunnan Province is on the rise, and the total volume varies unevenly among counties, with Ruili City in the west and Mengla County in the south as the representative counties with higher total trade volume, while the over‐all trade volume in Ximeng County in the southwest and Lushui County in the northwest is smaller. ② From 2010 to 2020, the development pattern of county border trade in Yunnan Prov‐ ince varies. ③ During the same period, the border trade development in the western and south‐ eastern border counties is high and the growth rate is stable; the development in the northwestern and southwestern counties is low and the growth is fast; the development in the southern coun‐ ties is high and the growth is slow. ④ The main driving factors affecting the border trade in the counties factors are policy and transportation factors, and the secondary driver is GDP per capita, while there are differences in the driving factors of border counties with different neighboring countries. [ABSTRACT FROM AUTHOR]

In order to eliminate the nonlinear aerodynamic behaviour of a symmetric airfoil within the low angles of attack at low Reynolds number, this paper establishes a low Reynolds number airfoil optimization design procedure based on Gaussian process regression model and NSGA-II multi-objective genetic algorithm coupled with RANS numerical method. Then this paper carries out the airfoil optimization design with the average cruise factor in the range of small angle of attack of multiple states as the objective function. The results show that the optimized airfoil exhibits pronounced geometric bump and effectively alters the position and type of the laminar separation bubble. The aerodynamic characteristics of the airfoil are significantly improved, and the nonlinear phenomenon of the lift coefficient within the small angle of attack range at Re=4×104 basically disappears. Further analysis reveals that the bump of the optimized airfoil enhances the convective influence of the wall, which enhances the resistance of the incoming flow to the upward pressure gradient, thus improving the airfoil aerodynamic characteristics. [ABSTRACT FROM AUTHOR]

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