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Objective To conclude the changes of laboratory results of novel corona virus disease 2019(COVID 19) confirmed patients. So as to provide bases of clinical diagnosis and treatment. Methods The laboratory test results of 34 7 patients with confirmed COVID 19 who were hospitalized in Ezhou Third Hospital and Ezhou Leishan Hospital on February 10, 2020 and March 4, 2020 were collected to analyze the level and characteristics of each test index. Results The male to female ratio of COVID 19 patients was 1. 08 : 1, and the mean age was ( 52. 9±15. 1) years. The results of laboratory examination showed that the white blood cell count (WBC) (99. 71 % ), absolute neutrophils ( NEUT) (95 . 68 % ) were normal or decreased, the absolute value of eosinophiles (EOS) (17. 87 % ) decreased, absolute value of lymphocytes (30 . 84 % ) decreased and the neutrophilslymphocytes ratio ( NEUT/ LYMPH) (36. 31 %) increased. The Creactive protein (FR CRP) (18. 44 % ) increased throughout the whole process, and the level of procalcitonin ( PCT ) was not significantly abnormal. Albumin (47. 55%) was decreased, alanine aminotransferase ( ALT) (30. 55 %), as partate aminotransferase ( AST) ( 21. 61 % ), glutamyl transp eptidase ( GGT) ( 24. 21 % ), lactate dehydrogenase (LDH) (20 . 46 % ) were increased, total bilirubin (TB), direct bilirubin (DB), indirect bilirubin (IB) were not abnormal. Fibrinogen ( FBG)(20. 28%) and D dimer ( 44. 06%) increased. Conclusion All ages of male or female can be infected with SARS CoV 2. Be s ides viral nucleic acid testing and CT scans, results of blood routine, clinical biochemical tests and blood coagulation tests can also assist clinical diagnosis and treatment. Results of ALT,GGT,Fbg,D D increased in young and mid age adults should be paid attention to and adjust treatments in time. [ABSTRACT FROM AUTHOR]