Search

【目的】研究小鼠肠I/R损伤早期肠黏膜中长链非编码RNA（lncRNA）的变化，建立差异表达的lncRNA表达谱及功能角色，并对lncRNA和凋亡相关基因进行编码-非编码基因共表达（CNC）生物信息学分析。【方法】采用lncRNA芯片高通量筛选小鼠肠I/R损伤早期肠黏膜中差异lncRNA的变化并用qRT-PCR验证芯片重复性，通过对与lncRNA同时差异表达的mRNA进行基因本体论（GO）富集分析，重点分析凋亡相关功能。最后，挑选差异变化的已知凋亡相关基因的mRNA，通过CNC分析计算出与之显著相关的IncRNA-mRNA关系对，构建差异lncRNA和凋亡mRNA共表达网络。【结果】与假手术组相比，肠I/R后小鼠肠上皮细胞lncRNA表达谱发生了显著变化，其中表达上调的lncRNA有1503个，表达下调的lncRNA有2099个（Foldchange≥2，P

Objective: To observe the perioperative analgesic effect and the changes of T lymphocyte subsets of ultrasound- guided lumbar quadratus block with different concentrations of ropivacaine before anesthesia induction in patients undergoing laparoscopic surgery for colorectal cancer. Methods Sixty patients with colorectal cancer undergoing laparoscopic surgery were randomly divided into group H, group M and group L, with 20 patients in each group. All patients in the three groups underwent ultrasound-guided lumbar quadratus block with ropivacaine. The concentrations of ropivacaine were 0. 5%, 0. 375%, and 0. 25%, respectively. After completing lumbar quadratus block, they were treated with general anesthesia, laparoscopic surgery and follow-up. The VAS scores at 2, 6, 12, 24 and 48 h after operation at rest and at exercise each, the first pressing time of postoperative analgesic pump, the dosage of sufentanil and the score of analgesic satisfaction were observed. The intraoperative dosage (propofol dosage, remifentanil dosage), the first exhaust time, the first time to the ground, the total hospital stay and other related indexes were observed. The hemodynamic indexes, mean arterial pressure (MAP)and heart rate (HR)were observed at the time points of entering the room (T0), starting skin incision (T1), tumor resection (T2)and tracheal catheter extraction (T3). The proportions of CD3+, CD4+, CD8+ and CD4+/CD8+ in T lymphocyte subsets were observed at 6, 12, 24 and 48 h after operation. Nausea and vomiting, lower limb movement block, pruritus, urinary retention and sensory deterioration were observed. Results The VAS scores at 6, 12, 24 and 48 h after operation at rest and at exercise each in the three groups were significantly higher than those at 2 h after operation (all P<0. 05), the VAS scores at rest and exercise at 6, 12 and 24 h after operation in the group M and group H were significantly lower than those in the group L (all P<0. 05), and the VAS scores at 48 h after operation at exercise in the group M and group H were significantly lower than those in the group L (all P<0. 05). The dosage of remifentanil, propofol and sufentanil in the group M and group H were significantly lower than those in the group L (all P<0. 05), the first pressing time of analgesic pump and the score of analgesic satisfaction were significantly higher than those in the group L (all P< 0. 05). MAP and HR at T1 and T2 were significantly higher than those at T0 (all P<0. 05), MAP and HR in the group M and group H were significantly lower than those in the group L at T1 and T2 (all P<0. 05). The proportions of CD3+, CD4+, CD8+ and CD4+/CD8+ in T lymphocyte subsets at 12 h, 24 h and 48 h after operation were significantly higher than those at 6 h after operation (all P<0. 05), the proportions of CD3+, CD4+, CD8+ and CD4+/CD8+ in T lymphocyte subsets of group M and group H at 12 h after operation were significantly higher than those of group L (all P<0. 05), and the proportions of CD4+ and CD4+/CD8+ in T lymphocyte subsets of group M and group H at 24 h after operation were significantly higher than those of group L (all P<0. 05). The total incidence of postoperative adverse reactions in the group H was significantly higher than those of group M and group L (all P<0. 05). Conclusion Ultrasound-guided lumbar quadratus block with 0. 375% ropivacaine has a good effect on perioperative analgesia in patients with colorectal cancer undergoing laparoscopic surgery, the total incidence of adverse reactions is low, and it is conducive to the recovery of T cell immune function after operation. [ABSTRACT FROM AUTHOR]

In view of the multi-attribute decision problem in which the value of attribute was in the form of Pythagorean 2-tuple linguistic numbers, considering the bounded rational behavior of decision maker, this paper proposed the decision making method of the preference ranking organization method for enrichment evaluations (PROMETHEE) based on prospect theory. Firstly, this paper introduced the related concepts of the Pythagorean 2-tuple linguistic set, improved the existing distance of P2TLN, and defined the improved distance by use of the score function and the exact function of P2TLN, and verified the properties of the improved distance. Secondly, in order to reflect the risk preference of decision makers when comparing decision information, it constructed the priority function of P2TLN by combining the prospect value function. Then, it compared the alternatives in pairs by use of the priority function, and ranked the alternatives by calculating the net flow of each scheme. Finally, this paper gave an example about the evaluation of logistics companies to show the feasibility and effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Zhejiang University (Science Edition) is the property of Journal of Zhejiang University (Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Zhejiang University (Science Edition) is the property of Journal of Zhejiang University (Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Pythagorean hesitant fuzzy set as a new generalization of Pythagorean fuzzy and hesitant fuzzy set can handle fuzzy information more flexibly in multiple attribute decision making. In view of the important role of aggregation operator in multiple attribute decision making and under the condition of the imperfect aggregation operator in Pythagorean hesitant fuzzy decision environment, this paper systematically investigated Pythagorean hesitant fuzzy aggregation operators. It defined some Pythagorean hesitant fuzzy aggregation operators based on the operational laws of Pythagorean hesitant fuzzy numbers, including Pythagorean hesitant fuzzy ordered weighted average operator ( PHFOWA), generalized ordered weighted average operator (GPHFOWA), hybrid average operator ( PHFHA), Pythagorean hesitant fuzzy ordered weighted geometric average operator ( PHFOWG),generalized ordered weighted geometric average operator( GPHFOWG) and hybrid geometric average operator ( PHFHG). It gave the mathematical expression of these operators by derivation and discussed in detail some desirable properties such as boundedness, monotonicity and commutativity. Finally, this paper proposed a decision making method based on Pythagorean hesitant fuzzy aggregation operators, and used an applied example lo illustrate the feasibility and applicability of the proposed method. [ABSTRACT FROM AUTHOR]

Copyright of Cross-Strait Law Review is the property of Angle Publishing Co., Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

It is found from the numerical example that the range of parameter in the ranking method of additive consistent fuzzy judgment matrix in the related literatures is not appropriate, and by analyzing the process of proof, the problem existed in the ranking method is due to indiscriminate scale. Hereby, it is pointed out that the series of results in the related literatures are only suited to additive consistent fuzzy judgment matrix in scale 0 ~ 1. Then, based on scale 0.1 ~ 0.9, the ranking method and results about additive consistent fuzzy judgment matrix are reproved. Finally, generalized fuzzy scale is defined, and the ranking method and results about additive consistent fuzzy judgment matrix with generalized fuzzy scale are discussed, which realized the ranking methods and results in the related literatures unification in forms. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Central China Normal University is the property of Huazhong Normal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

将拟有序加权几何算子(QOWG)推广至连续区间数上，提出了连续QOWG算子(CQOWG)，探讨了其特殊情况和相关性质.其次，定义了 CQOWG算子的orness测度，研究了 orness测度的性质.然后，定义了加权连续QOWG算子(WCQOWG)、有序加权连续QOWG算子(OWCQOWG)以及组合连续QOWG算子(CCQOWG)，并讨论了它们的性质.最后，提出了基于连续QOWG算子的多属性群决策方法，并通过决策实例说明其可行性与有效性.