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【Objective】Deqing County, Guangdong Province is a native habitat of Morinda officinalis How., a genuine medicinal herb in China. In the study, the genetic diversity of germplasm resources of 24 varieties of Morinda officinalis How. were analyzed.【Method】A total of 24 Morinda officinalis How. resources collected from Deqing County as research objects, and principal component analysis and molecular marker methods (SRAP and CDD) were used to analyze the genetic diversity of 24 Morinda officinalis How. materials.【Result】Phenotypic analysis showed that, in the cluster map based on principal component analysis, Guanwei Town, Gaoliang Town, Fengcun Town and Gaoliang Town were clustered in four groups. In addition,100 and 98 total bands were obtained in 18 pairs of SRAP primer combinations and 16 CDDP primers, among them, there were 50 SRAP polymorphic bands, resulting in a polymorphism ratio of 50%. The average genetic similarity coefficient (GS) was 0.87, and the GS ranged from 0.71 to 0.97. There were 80 polymorphic bands in CDDP, with a polymorphism ratio of 79.0%. The GS among germplasm resources ranged from 0.71 to 0.96, with an average (GS) of 0.86. When the coefficient was 0.82, both SRAP and CDDP molecular markers showed certain similarities among the germplasm resources of Gaoliang Town, Guanxu Town and Fengcun Town.【Conclusion】Combined with the clustering results of phenotypic and molecular marker, the genetic relationship is closest between Gaoliang Town and Guanwei Town as well as Gaoliang Town and Fengcun Town. The results of SRAP and CDDP molecular marker methods have certain differences in the genetic diversity of Morinda officinalis How., and the combined analysis can better reflect the genetic diversity of Morinda officinalis How. and the phylogenetic relationship of Morinda offi cinalis How. resources. [ABSTRACT FROM AUTHOR]

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective Exploring the efficacy and safety of botulinum toxin type A （BTX-A） combined with pulsed radiofrequency（PRF） in the treatment of postherpetic neuralgia（PHN）. Methods A total of 80 patients with PHN were collected. They were randomly divided into experimental group （Group B）and control group （Group C）, Group B was treated with BTX-A intradermal injection combined with PRF, and Group C was treated with lidocaine intradermal injection combined with PRF. Numeric pain score （NRS）, Simplified McGill Pain Questionnaire （SF-MPQ）and Sleep Quality Score （QS）were used to assess the patients' pain level and sleep quality preoperatively, 1, 3, and 7 days postoperatively, and 1, 2, and 3 months postoperatively. The patients' postoperative adverse reactions were collected. Interleukin-1β （IL-1β）and calcitonin gene-related peptide （CGRP）levels in patients' serum were measured preoperatively and 3 days postoperatively. Results The NRS scores, SF-MPQ scores, and QS scores of group B and group C were significantly lower at all postoperative time points compared to preoperative ones （P < 0.05）. The NRS and SF-MPQ score were significantly lower in group B at 1, 2, and 3 months postoperatively compared with group C（P < 0.05）; and group B had significantly lower QS scores at 2 and 3 months postoperatively （P < 0.05）. The effective rate of pain relief at 3 months postoperatively in group B （90%） was statistically significant （P < 0.05） compared with group C （56.7%）. No serious adverse reactions occurred in either group. The levels of IL-1β and CGRP in serum of patients in both groups were significantly decreased at 3 days after surgery compared with the preoperative period, and the degree of decrease of IL-1β and CGRP in group B was more significant than that in group C （P < 0.05）. Conclusion BTX-A combined with PRF treatment for PHN can effectively reduce its pain level, improve the quality of sleep, and is safe. [ABSTRACT FROM AUTHOR]

Copyright of Journal of South China University of Technology (Natural Science Edition) is the property of South China University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Pesticide Science / Nongyaoxue Xuebao is the property of Chinese Journal of Pesticide Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] The aims of this study are to investigate the dynamics of vegetation coverage changes and their underlying drivers in the northwestern Sichuan Plateau region, and to supply a theoretical foundation for regional vegetation conservation and restoration initiatives. [Methods] MODIS NDVI was utilized as the foundational dataset. By integrating Sen′s trend analysis, Manna-Kendall test, and the Hurst model, we comprehensively analyzed the spatial distribution characteristics, trends spanning nearly 20 years, and prospective sustainable state of the region. Moreover, the study employed geographical detectors to delve into the underlying driving forces. [Results](1) The overall vegetation cover in the area was relatively great in the east.(2) In the whole period, the vegetation cover of 80.56% of the regions showed no significant change, and the vegetation cover of the regions with significant improvement accounted for 17.80%.(3) The Hurst index indicates that the overall vegetation cover will be in the development state of no significant change in the future.(4) The one-factor explanatory power of elevation, annual average temperature and soil type surpassed more than 30%. They were the main factors driving the formation of differences in vegetation cover distribution patterns. The interaction and synergy of each factor were enhanced. There were obvious differences in the intervals or types of suitable vegetation growth of each factor.(5) The natural factors dominated the formation of the overall pattern of spatial distribution of regional vegetation cover, whose land use types were the key factors in driving its dynamic change. In the past 20 years, the vegetation cover in the West Sichuan Plateau had changed significantly, and natural factors had dominated the spatial distribution pattern of regional vegetation cover. [Conclusion] In the past 20 years, the vegetation cover in the study area had a clear change pattern. Although natural factors dominate the spatial layout of vegetation cover, human activities are the main driving factors for its pattern change. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Mechanical & Electrical Engineering is the property of Mechanical & Electrical Engineering Magazine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Jiaotong University (Medical Science) is the property of Journal of Shanghai Jiaotong University (Medical Science) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The influence of strand saddle tube's diameter on the stress condition of each member in the pylon anchorage zone was analyzed based on Wangjia River Bridge and field test. A strong-weak zone model of pylon anchorage component with strand-separating saddle was proposed. The finite element models of saddle anchorage and crossing anchorage were established, and the stress of the components of the two anchorages were compared. The results show that the cable stresses of saddle anchorage are nearly 51. 4% of those in the cross-anchorage under the same conditions, and the stress conditions of saddle anchorage are better than those of the latter overall. The force transmission paths and optimized geometric configuration of saddle anchorage zone, and the generalized strong-weak zoning model of concrete around the ends of strand-separation tube are obtained by using the topology optimization method. The upside length of the generalized model is approximately equal to 0. 55 times outer diameter of strand-separation tube, and the failure angle of concrete is about 56°. Finally, the concrete strength of the critical section are checked. The strong-weak model could provide a theoretical reference to the similar structural design. [ABSTRACT FROM AUTHOR]

Copyright of CT Theory & Applications is the property of Editorial Department of CT Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Systems Engineering & Electronics is the property of Journal of Systems Engineering & Electronics Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Computer Engineering & Science / Jisuanji Gongcheng yu Kexue is the property of Computer Engineering & Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering for Thermal Energy & Power / Reneng Dongli Gongcheng is the property of Journal of Engineering for Thermal Energy & Power and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal Of Sichuan University (Natural Sciences Division) / Sichuan Daxue Xuebao-Ziran Kexueban is the property of Editorial Department of Journal of Sichuan University Natural Science Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Large Electric Machine & Hydraulic Turbine is the property of Large Electric Machine & Hydraulic Turbine Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Coal Science & Technology (0253-2336) is the property of Coal Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Atomic & Molecular Physics (1000-0364) is the property of Journal of Atomic & Molecular Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Engineering for Thermal Energy & Power / Reneng Dongli Gongcheng is the property of Journal of Engineering for Thermal Energy & Power and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Agronomica Sinica is the property of Crop Science Society of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Electroplating & Finishing is the property of Electroplating & Finishing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Remote Sensing is the property of Editorial Office of Journal of Remote Sensing & Science Publishing Co. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Experimental Technology & Management is the property of Experimental Technology & Management Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

At present, the standard still has certain limitations on the use of machine-made sand (MMS). It does not consider the impact of different lithology and grain types on the particle gradation. The performance of MMS concrete in actual production is not satisfactory. The effect of particle size on the fineness modulus (FM) guides the production of MMS. By reducing the range of value of the MMS grade required by the specification, the granite MMS concrete bleeding condition is improved. At the same time, a sand rate correction method considering the FM, micro fines content, and water-cement ratio is proposed, which is a new attempt for the use of granite MMS concrete and accumulates experience for the subsequent engineering application of granite MMS concrete. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects and mechanism of microRNA ( miR-130a) on proliferation and apoptosis of pancreatic cancer cells by targeting FOS-like antigen 1 (FOSLl). Methods: Pancreatic cancer cells PANC-1 were routinely cultured and divided into the NC group and miR-130a mimic group. Cells in the NC group were transfected with control, miR-130a mimic group with miR-130a simulant by Liposome 2000. CCK-8 was used to detect the proliferation activity of cells. Flow cytometry was used to detect the apoptosis of cells. Targetscan7. 1 prediction software and dual luciferase reporter gene test were used to detect miR-130a targeted-regulating FOSLl gene. The FOSLl overexpression plasmid was constructed, and co-transfected into PANC-1 cells with miR-130a, and then PANC-1 cells were divided into the NC group, miR-130a mimic group, and miR-130a mimic + oe-FOSLl group. Cells in the NC group were transfected with control, miR-130a mimic group with miR-130a mimic, and the miR-130a mimic + oe-FOSLl group with miR-130a mimic and FOSLl overexpression plasmid. Western blotting was used to detect the expression of p53 protein in each group. Results: Compared with the NC group, the proliferation ab山ty of PANC-1 cells in the miR-130a mimic group decreased (P < 0. 05), and apoptosis increased (P < 0. 05). The double luciferase reporter gene test coufirmed that FOSLl was a target gene of miR-130a. Compared with the NC group, the proliferation ability of PANC-1 cells in miR-130a mimic group and the miR-130a mimic + oe-FOSLl group decreased, and apoptosis increased (both P < 0. 05). Compared with the miR 130a mimic group, the proliferation ability of PANC-1 cells in the miR-130a mimic + oe-FOSLl group increased, and apoptosis decreased (both P < 0. 05). Compared with the NC group, the expression of FOSLl protein in the miR-130a mimic group and miR-130a mimic + oe-FOSLl group decreased and p53 protein increased ( both P < 0. 05 ). Compared with the miR-130a mimic group, the expression of FOSLl protein in the miR-130a mimic + oe-FOSLl group increased and p53 protein expression decreased ( both P < 0. 05 ). Conclusion: MiR-130a targeting FOSLl can inhibit the proliferation of pancreatic cancer cells and promote apoptosis by up-regulating the expression of p53. [ABSTRACT FROM AUTHOR]

Objective To verify the value of whole genomic copy number variation (WGCNV) detection and scoring system in the diagnosis and prognosis of lung adenocarcinoma. Methods Seventy-six lung adenocarcinoma specimens including ninety-one tumor samples and twenty adjacent non-tumor lung tissue samples were collected using Laser capture microdissection (LCM). Whole genomic amplification (WGA) was used to enrich DNA and construct a sequencing library for next generation sequencing (NGS). Changes of larger than 5Mb CNV in this study were analyzed and scored. The nuclear grading and score of tumor cells in the surgery and pleural effusion cytology of lung adenocarcinoma specimens were evaluated separately. For each case, we evaluated (1) nuclear size, (2) mitotic counts, (3) nuclear atypia, (4) atypical mitoses. The data of disease-free survive (DFS) and overall survive (OS) were collected for assessing the prognostic value of WGCNV score. Meanwhile, receiver operating characteristic (ROC) and area under curve (AUC) were used to define a cut-off value and evaluate the diagnostic significance in lung adenocarcinoma. Results The WGCNV scores of twenty adjacent non-tumor lung tissue samples were treated as normal control and all of WGCNV scores of tumor samples range from 0 to 9.95, the median score was 2.7. The WGCNV scores were divided into three groups: low score group <1.74, medium score grade 1.74~4.23, high score grade >4.23. The WGCNV score was positively associated with the nuclear grade scoring (r=0.780 90, P<0.001). The result for evaluation of prognostic value of the WGCNV scores showed that comparing with low WGCNV score group, Hazard Ratio (HR) of medium score group was 4.11 (95%CI=0.72~23.57) and high score group was 2.07 (95%CI=0.30~14.12). These results suggested that the risks of the medium and high WGCNV score group elevated. According to the analysis results of ROC curve, when the cut off value was 0.01, the sensitivity and specificity for lung adenocarcinoma diagnosis were 97.8% and 95.0% respectively, the positive predictive value (PPV) and negative predictive value (NPV) were 99.0% and 90.1%, respectively, the AUC was 0.981. In the differentiation of adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) group and invasive adenocarcinoma group, when the cut off value was 1.8, the sensitivity and specificity between the two groups were 78.1% and 94.4%, and the PPV and NPV were 98.0% and 52.0%, respectively, the AUC was 0.896. Conclusion This study verifies that WGCNV scoring system has a potential diagnostic and prognostic value in lung adenocarcinoma. [ABSTRACT FROM AUTHOR]

PHengLEI is a software platform of Computational Fluid Dynamics (CFD) developed by China Aerodynamics Research and Development Center (CARDC) with completely independent intellectual property rights. It has been widely used in China. As an important part of the national numerical wind tunnel system, PHengLEI are integrating the discipline physical models including helicopter rotor, aircraft icing, wind engineering, chemical reaction and combustion, virtual flight, high order method on both structured and unstructured grids. In order to meet the needs of integrated development of multidisciplinary and multi-physical models and to adapt to the next generation of high-performance computer hardware, based on the existing work, the architecture and data structure of the next-generation PHengLEI software are further designed. [ABSTRACT FROM AUTHOR]

Copyright of Journal of East China University of Science & Technology is the property of Journal of East China University of Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tianjin Medical Journal is the property of Tianjin Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the effect of leonurine( LEO) on the cerebral ischemia-reperfusion injury mice and its mechanism. Methods Totally 120 healthy male Kunming mice were randomly divided into three groups: the sham group,the model group,and the LEO group,with 40 mice in each group. The cerebral ischemia reperfusion models were established by the middle cerebral artery occlusion method in mice of all groups except the sham group. The mice in the sham operation group were operated in the same method except that the suture was not inserted. At 30 minutes after model establishment,the mice in the LEO group was intraperitoneally injected with LEO 15 mg/( kg·d). The mice in the sham group and the model group received the same volume of normal saline. At 24 h after model establishment,the brain tissues of the infarction site were taken and the volume of cerebral infarction was measured by TTC staining. The brain water content was weighed to evaluate the degree of brain edema. The blood-brain barrier permeability was measured by Evans blue( EB) method. The morphology of brain tissue was observed by HE staining. The expression of p-p38 and tight junction protein( ZO-1) protein in the brain tissues was detected by Western blotting. The expression of inflammatory factors including IL-1β,IL-6 and tumor necrosis factor-α( TNF-α) mRNA was detected by RT-PCR. Results The cerebral infarction volume ratio,brain water content,and EB content in the model group were higher than those in the sham operation group and were lower than those in the model group( all P < 0. 05). In the model group,a large number of neurons showed pathological changes of ischemic anoxic necrosis. However,compared with the model group,the pathological changes of brain tissues in the LEO group were significantly improved. The expression of p-p38 protein was higher and the expression of ZO-1 protein was lower in the model group than that in the sham group. The expression of p-p38 protein was lower and the expression of ZO-1 protein was higher in the LEO group than that in the model group( P < 0. 05). The expression levels of IL-1β,IL-6,and TNF-α mRNA were higher in the model group than those in the sham group. The expression levels of IL-1β,IL-6 and TNF-α mRNA were lower in the LEO group than those in the model group( all P < 0. 05). Conclusion LEO can improve the nerve damage and alleviate the permeability of blood-brain barrier in mice with ischemia-reperfusion.The mechanism may be related to the inhibition of p38 MAPK signaling pathway and reduction of the inflammatory response. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)